### Comment:
And the odds were against you - thus the phrase 'high risk, high reward.' Sounds like you got the high reward. Congratulations my guy.

### REPLY:
Explain how the odds were against me? Did I not understand AAV serotypes or how they work?  Did I not understand gene replacement?  Were the promoters confusing to me?  Was the plasmid design over my head?   Please explain

### END.