### Comment:
What are your thoughts regarding kidney risks? T1Ds put quite a bit of stress on their kidneys due to the increased workload of filtering blood glucose. Wouldn't this drug's mechanism further increase this stress? Seems like these sorts of effects would be very difficult to capture in a one year trial.

### REPLY:
Not really worried about it. Might cause a little bit of strain but usually these meds are not causing any kidney injury in patients as long as they remain hydrated. They usually have cutoffs for use in patients with CKD, but I have no heard reports of them worsening renal funciton in patients. The T2dm patients are usually on renal-protective therapies anyway like ACE/ARBs so I wouldn't worry about it.

### END.