Three UniRef tables UniRef100 , UniRef90 and UniRef50 ) are available for download : UniRef100 combines identical sequences and sub-fragments into a single UniRef entry ; and UniRef90 and UniRef50 are built by clustering UniRef100 sequences into clusters based on the CD-HIT algorithm [ 16 ] such that each cluster is composed of sequences that have at least 90 % or 50 % sequence similarity , respectively , to the representative sequence .
godzik a clustering of highly homologous sequences to reduce the size of large protein databases bioinformatics
W Li L Jaroszewski
The UniProt Non-redundant Reference ( UniRef ) databases combine closely related sequences into a single record where similar sequences are grouped together . Three UniRef tables UniRef100 , UniRef90 and UniRef50 ) are available for download : UniRef100 combines identical sequences and sub-fragments into a single UniRef entry ; and UniRef90 and UniRef50 are built by clustering UniRef100 sequences into clusters based on the CD-HIT algorithm [ 16 ] such that each cluster is composed of sequences that have at least 90 % or 50 % sequence similarity , respectively , to the representative sequence . NCBI resources -- three data sources from NCBI were used in this study : GenPept , RefSeq , and Entrez GENE .
Three UniRef tables UniRef100 , UniRef90 and UniRef50 ) are available for download : UniRef100 combines identical sequences and sub-fragments into a single UniRef entry ; and UniRef90 and UniRef50 are built by clustering UniRef100 sequences into clusters based on the CD-HIT algorithm @@CITATION such that each cluster is composed of sequences that have at least 90 % or 50 % sequence similarity , respectively , to the representative sequence .