Sopravvivenza e progressione tumorale sono state esaminate in cinque ampi studi controllati, che hanno coinvolto in totale 2833 pazienti, quattro dei quali erano studi in doppio cieco, controllati con ###>Survival and tumour progression have been examined in five large controlled studies involving a total of 2833 patients, of which four were double-blind placebo-controlled studies and one was an open- label study.