Ridotta funzionalità renale L’ AUC di lacosamide aumenta approssimativamente del 30% in pazienti con insufficienza renale lieve ###>Renal impairment The AUC of lacosamide was increased by approximately 30% in mildly and moderately and 60% in severely renal impaired patients and patients with endstage renal disease requiring hemodialysis compared to healthy subjects, whereas cmax was unaffected.