Lorsque les canaux de transport actif commencent à se fermer, les nutriants transitant dans les voies de passage intercellulaires ne peuvent atteindre la cellule, laquelle accuse un déficit de nutriments et d’énergie. ###>As the active transport channels begin to close down, you have a circumstance where nutrients that are in the river between the cells are not able to get into the cell. When nutrients cannot get into the cell, the cell becomes nutrient and energy deficient.