Aangezien lage doseringen ritonavir (100 mg tweemaal daags) geen significante invloed vertoont op de methadonconcentratie wordt er geen ###>Given that low dose ritonavir (100 mg twice daily) has been shown to have no significant effect on methadone concentrations, no interaction is expected if methadone is co-administered with REYATAZ and ritonavir, based on these data.