Deze farmacologisch gemedieerde bijwerkingen, reeds bekend van preklinische studies met ACE-remmers en angiotensine II-receptorantagonisten konden worden voorkomen door oraal extra zout toe te dienen. ###>These pharmacologically- mediated undesirable effects, known from preclinical studies with both angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists, were prevented by oral saline supplementation.