Dog skal denne faste dosis- kombination gives med forsigtighed til patienter med mild til moderat nedsat nyrefunktion (kreatininclearance ≥ 30 ml/ min, men < 60 ml/ min). ###>However, in patients with mild to moderate renal impairment (creatinine clearance ≥ 30 ml/ min but < 60 ml/ min) this fixed dose combination should be administered with caution.