  Ischemia leading to heart attacks and strokes is the major cause of deaths in
the world. Whether an occlusion occurs or not, depends on the ability of a
growing thrombus to resist forces exerted on its structure. This manuscript
provides the first known in vivo measurement of the stresses that clots can
withstand, before yielding to the surrounding blood flow. Namely,
Lattice-Boltzmann Method flow simulations are performed based on 3D clot
geometries. The latter are estimated from intravital microscopy images of
laser-induced injuries in cremaster microvasculature of live mice. In addition
to reporting the blood clot yield stresses, we also show that the thrombus
'core' does not experience significant deformation, while its 'shell' does.
This indicates that the latter is more prone to embolization. Hence, drugs
should be designed to target the shell selectively, while leaving the core
intact (to minimize excessive bleeding). Finally, we laid down a foundation for
a nondimensionalization procedure, which unraveled a relationship between clot
mechanics and biology. Hence, the proposed framework could ultimately lead to a
unified theory of thrombogenesis, capable of explaining all clotting events.
Thus, the findings presented herein will be beneficial to the understanding and
treatment of heart attacks, strokes and hemophilia.

Cell Behavior;Tissues and Organs