  Alzheimer's disease is the most common cause of dementia. It is the
fifth-leading cause of death among elderly people. With high genetic
heritability (79%), finding disease causal genes is a crucial step in find
treatment for AD. Following the International Genomics of Alzheimer's Project
(IGAP), many disease-associated genes have been identified; however, we don't
have enough knowledge about how those disease-associated genes affect gene
expression and disease-related pathways. We integrated GWAS summary data from
IGAP and five different expression level data by using TWAS method and
identified 15 disease causal genes under strict multiple testing (alpha<0.05),
4 genes are newly identified; identified additional 29 potential disease causal
genes under false discovery rate(alpha < 0.05), 21 of them are newly
identified. Many genes we identified are also associated with some autoimmune
disorder.

Applications;Genomics