  The neural dynamics underlying brain activity are critical to understanding
cognitive processes and mental disorders. However, current voxel-based
whole-brain dimensionality reduction techniques fall short of capturing these
dynamics, producing latent timeseries that inadequately relate to behavioral
tasks. To address this issue, we introduce a novel approach to learning
low-dimensional approximations of neural dynamics by using a sequential
variational autoencoder (SVAE) that represents the latent dynamical system via
a neural ordinary differential equation (NODE). Importantly, our method finds
smooth dynamics that can predict cognitive processes with accuracy higher than
classical methods. Our method also shows improved spatial localization to
task-relevant brain regions and identifies well-known structures such as the
motor homunculus from fMRI motor task recordings. We also find that non-linear
projections to the latent space enhance performance for specific tasks,
offering a promising direction for future research. We evaluate our approach on
various task-fMRI datasets, including motor, working memory, and relational
processing tasks, and demonstrate that it outperforms widely used
dimensionality reduction techniques in how well the latent timeseries relates
to behavioral sub-tasks, such as left-hand or right-hand tapping. Additionally,
we replace the NODE with a recurrent neural network (RNN) and compare the two
approaches to understand the importance of explicitly learning a dynamical
system. Lastly, we analyze the robustness of the learned dynamical systems
themselves and find that their fixed points are robust across seeds,
highlighting our method's potential for the analysis of cognitive processes as
dynamical systems.

Neurons and Cognition;Computational Engineering, Finance, and Science;Machine Learning