  I present a Hamiltonian model and a computational method suitable to evaluate
structural and thermodynamic properties of helical molecules embedded in
crowded environments which may confine the space available to the base pair
fluctuations. It is shown that, for the specific case of a short DNA fragment
in a nanochannel, the molecule is markedly over-twisted and stretched by
narrowing the width of the channel.

Soft Condensed Matter;Biological Physics;Biomolecules