  Histamine is a critical mediator of IgE/ cell-mediated anaphylaxis, a
neurotransmitter and a regulator of gastric acid secretion. Histamine is a
monoamine synthesized from the amino acid histidine through a reaction
catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl
group from histidine. Despite the importance of histamine, transcriptional
regulation of HDC gene expression in mammals is still poorly understood. In
this Review, we focus on discussing advances in the understanding of molecular
regulation of mammalian histamine synthesis.

Molecular Networks;Genomics