  We demonstrate how direct simulation of stochastic, individual-based models
can be combined with continuum numerical analysis techniques to study the
dynamics of evolving diseases. % Sidestepping the necessity of obtaining
explicit population-level models, the approach analyzes the (unavailable in
closed form) `coarse' macroscopic equations, estimating the necessary
quantities through appropriately initialized, short `bursts' of
individual-based dynamic simulation. % We illustrate this approach by analyzing
a stochastic and discrete model for the evolution of disease agents caused by
point mutations within individual hosts. % Building up from classical SIR and
SIRS models, our example uses a one-dimensional lattice for variant space, and
assumes a finite number of individuals. % Macroscopic computational tasks
enabled through this approach include stationary state computation, coarse
projective integration, parametric continuation and stability analysis.

Adaptation and Self-Organizing Systems;Populations and Evolution