  We propose a modeling approach to study how mature biofilms spread and
colonize new surfaces by predicting the formation and growth of satellite
colonies generated by dispersing biofilms. This model provides the basis for
better understanding the fate and behavior of dispersal cells, phenomenon that
cannot, as yet, be predicted from knowledge of the genome. The model results
were promising as supported by the experimental results. The proposed approach
allows for further improvements through more detailed sub-models for front
propagation, seeding, availability and depletion of resources. The present
study was a successful proof-of-concept in answering the following questions:
Can we predict the colonization of new sites following biofilm dispersal? Can
we generate patterns in space and time to shed light on seeding dispersal? That
are fundamental issues for developing novel approaches to manipulate biofilm
formation in industrial, environmental and medical applications.

Biological Physics