  We report three-dimensional and time-dependent numerical simulations of the
propagation of electrical action potentials in a model of rabbit ventricular
tissue. The simulations are performed using a finite-element method for the
solution of the monodomain equations of cardiac electrical excitation. The
parameters of a detailed ionic ventricular cell model are re-fitted to
available experimental data and the model is then used for the description of
the transmembrane current and calcium dynamics. A region with reduced
conductivity is introduced to model a myocardial infarction scar. Electrical
activation times and density maps of the transmembrane voltage are computed and
compared with experimental measurements in rabbit preparations with myocardial
infarction obtained by a panoramic optical mapping method.

Quantitative Methods;Tissues and Organs