  DNA inside the cellular environment works under a confined space. An intense
research of the transcription and replication of DNA in the confined state is
structurally significant to command the self assembly of DNA in a chamber or
channel. In this work, we consider double stranded DNA (dsDNA) molecules of
different length and sequence and study the thermal stability of the molecule
in a confined space of conical geometry. Using the Peyrard-Bishop-Dauxois (PBD)
model, we evaluate the melting profile of dsDNA that is confined on one side of
the conical wall that mimics cellular boundary. Our results show that not only
the confinement, but also the geometry of the confined space plays a prominent
role in the stability of the molecule.

Soft Condensed Matter