  We propose a novel stimulated emission depletion (STED) microscopy based on
array detection and photon reassignment. By replacing the single-point detector
in traditional STED with a detector array and utilizing the photon reassignment
method to recombine the images acquired by each detector, the final photon
reassignment STED (prSTED) image could be obtained. We analyze the principle
and imaging characteristics of prSTED, and the results indicate that, compared
with traditional STED, prSTED can improve the signal-to-noise ratio (SNR) of
the image by increasing the obtained photon flux while maintaining the original
spatial resolution of STED. In addition, the SNR and resolution of prSTED are
strongly correlated with the intensity of depletion beam. Corresponding
theoretical and experimental analysis about this feature are also conducted. In
general, considering the enhanced signal strength, imaging speed and
compatibility with some other imaging techniques, we believe prSTED would be a
helpful promotion in biomedical imaging.

Optics