  Deep learning (DL)-based models have demonstrated good performance in medical
image segmentation. However, the models trained on a known dataset often fail
when performed on an unseen dataset collected from different centers, vendors
and disease populations. In this work, we present a random style transfer
network to tackle the domain generalization problem for multi-vendor and center
cardiac image segmentation. Style transfer is used to generate training data
with a wider distribution/ heterogeneity, namely domain augmentation. As the
target domain could be unknown, we randomly generate a modality vector for the
target modality in the style transfer stage, to simulate the domain shift for
unknown domains. The model can be trained in a semi-supervised manner by
simultaneously optimizing a supervised segmentation and an unsupervised style
translation objective. Besides, the framework incorporates the spatial
information and shape prior of the target by introducing two regularization
terms. We evaluated the proposed framework on 40 subjects from the M\&Ms
challenge2020, and obtained promising performance in the segmentation for data
from unknown vendors and centers.

Computer Vision and Pattern Recognition;Image and Video Processing