  In 1987, we analyzed the changes in correlation graphs between various
features of the organism during stress and adaptation. After 33 years of
research of many authors, discoveries and rediscoveries, we can say with
complete confidence: It is useful to analyze correlation graphs. In addition,
we should add that the concept of adaptability ('adaptation energy') introduced
by Selye is useful, especially if it is supplemented by 'adaptation entropy'
and free energy, as well as an analysis of limiting factors. Our review of
these topics, Dynamic and Thermodynamic Adaptation Models" (Phys Life Rev,
2021, arXiv:2103.01959 [q-bio.OT]), attracted many comments from leading
experts, with new ideas and new problems, from the dynamics of aging and the
training of athletes to single-cell omics. Methodological backgrounds, like
free energy analysis, were also discussed in depth. In this article, we provide
an analytical overview of twelve commenting papers and some related
publications.

Tissues and Organs