Let’s take a step back and consider a molecule that contains multiple stereocenters. If a molecule has one chiral center, we say there are two enantiomers. If a molecule has two stereocenters, there should be four possible stereoisomers. If a molecule has three stereocenters, there should be a maximum of eight stereoisomers. So, the maximum number of stereoisomers for a particular constitution is 2 n , when n is the number of chiral centers. You should proceed with caution, however, because some stereoisomers may be meso and therefore identical to other isomers. This will reduce the overall number of possible isomers. In summary, for a molecule with two chiral, non-racemic, non-meso stereocenters, there are four possible isomers – two pairs of enantiomers. As a general rule, when comparing stereoisomers, if one stereocenter changes R / S designation and the other stays the same, they are diastereomers. For enantiomers, all stereocenters must change.