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You are not likely to be prescribed acetylcysteine by your doctor beforehand if you intend to take a pill before getting hammered and then take Tylenol for the headache, like 1 hour after stopping to drink. I should also state that the chemical composition of N-acetylcysteine contains a sulfur group, meaning the medication will smell. It is known the tablet form is horrible to take.
Just keep drinking water to stay hydrated. I drank a bunch of Pedialyte to stave off a headache with better success than Gatorade.
"New treatment" = mental health
The headline made me think it was something actually new >

Could you take acetylcysteine to mitigate possible damage from the combo?