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Just have a different gang of outlaws and a new map. It would be the same as like GTA 4 vs GTA 5
Do you really trust Rockstar with remakes after GTA? >

honestly, not really, but it would be nice if they were to make a RDR1 remake and not fuck it up >

For the sake of the main story, I agree.  There's nothing more that needs to be explored with the Van Der Linde Gang or Arthur or Dutch or John or Jack.  
Some people have thrown around the idea of a spin off with Charles and/or Sadie perhaps taking place after the prologue in RDR2.   I just don't think a game about Charles moving to Canada to find a wife or Sadie moving to Brazil to become a bounty hunter for plantation owners would be as wildly interesting or sell as many units as the main story.  At least in the eyes of Rockstar.
Somebody will likely make a mod that has these potential side stories. >

I'd be good for another wild west game separate from the RDR games. >

That’s kinda hard to do become of how perfect RDR and RDR2 are. It’s kinda like making another Batman game separate from the Arkham series.