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Well, they simply don't care about someone being accused about sexual assault nearly as much as the pro-life issue. Imagine a scenario where Republicans were somehow pro-life but also had a policy where they wanted to execute all Christians. Now, obviously, pretty much all the pro-life voters are going to vote Democrat despite their pro-choice platform. So... does that still make them single-issue voters by your standards? There are other policies that would make them change their vote. There just aren't any policies that candidates would realistically espouse that are more important to them than the pro-life issue.
Similarly, there are people who wouldn't vote for Republicans who are anti-LGBT (i.e. most Republicans) because... they are members of the LGBT community. It's difficult to say a trans person is doing anything wrong by refusing to vote for someone who literally wants to criminalize their existence given the actual platforms of both parties. If the Democrats had on their platform that they also wanted to shoot all left-handed men over the age of 50, then maybe those trans people would vote Republican. But there are issues so pressing it's hard to see why any others would possibly matter in light of those for some individuals.
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For example, choosing a pediatrician for your child? Sure, making sure the doctor is well-qualified and well-trained to give excellent medical care is super important for most people.

You are comparing competing benefits/costs, with a deal breaker. For example, "Yeah this pediatrician is affordable, in network, really caring with kids, and close by, but he's also been convicted of sexual abuse of a minor" Like, it doesn't matter how great all of the other things are about him, you just can't use that pediatrician. 
People feel similarly about politicians.
For Pro Life people: "Yeah this politician is great in ways X Y and Z, but he supports people murdering babies, so no can do."
I really don't know why someone who believed abortion was killing a human child, would be irrational for choosing not to support anyone who advocated it? >

Choosing not to support a Democrat because they support legalized abortion, is different than choosing to unconditionally support a Republican because they support abortion restrictions.
In other words, sure, voting for Donald Trump meant that he would add justices who wanted to overturn RVW. But supporting him despite the fact that he was repeatedly accused of sexual assault? That kind of single-issue voting is my hang-up.