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This is something you should definitely try out, before you rush out to buy one.
The non-mirrored layout makes me do some incredibly uncomfortable hand gymnastics, which is a recipe for RMI.
The biggest issue I have is reaching down to the Num0 with my pinky.
That is not a normal movement, nor is it a comfortable one, for me.
The hilarious part about that is I'm actually left-handed, and have spent my entire life having to adapt to poor designs, created by right-handed people.
Dang. The universe it telling me I need a southpaw numpad. What board?