[%c_effect e6;square;e6;type;Mistake;persistent;true] Caruana probably felt that he should deliver a blow before Black manages to consolidate, but he missed the right way to do it.
1. d2d4  1... g8f6  2. c2c4  2... e7e6  3. g1f3  3... d7d5  4. b1c3  4... f8b4  5. c1g5  5... h7h6  6. g5f6  6... d8f6  7. e2e3  7... e8g8  8. a1c1  8... d5c4  9. f1c4  9... c7c5  10. e1g1  10... c5d4  11. c3e4  11... f6f5 All this is well-known theory. 11...Qe7 is more popular, but the move played in the game also has a good reputation, and Vokhidov had played it before. 12. e4g3  12... f5a5  13. a2a3  13... b4e7  14. e3d4  14... f8d8  15. d1e2  15... c8d7 [%c_effect d7;square;d7;type;Inaccuracy;persistent;true] A new move that leads to a difficult position for Black. 16. f1d1 There is an option that leads to a clear advantage for White, although the move played is not bad. 16... d7e8 