The standard reply.
1. e2e4  1... e7e5  2. g1f3  2... b8c6  3. f1c4  3... g8f6  4. d2d3  4... f8c5  5. a2a4 Just the 10th most popular move in this position. All sorts of move orders are possible in the Italian Opening. 5... d7d6  6. e1g1  6... a7a5  7. c1e3  7... c5e3  8. f2e3  8... e8g8  9. b1d2  9... c6e7 This natural move is a novelty. Black wants to move the knight to g6 and play …c6-d5.