This is not the main move, but in general you are fine if you capture toward the center.
1. e2e4  1... c7c5  2. g1f3  2... b8c6  3. f1b5 The Rossolimo variation is nowadays nearly as important as the Open Sicilian. 3... g7g6  4. e1g1  4... f8g7  5. b5c6 