Again looking for a repetition, but this isn't the best square.
1. e2e4  1... e7e5  2. g1f3  2... b8c6  3. f1c4  3... g8f6  4. d2d3  4... h7h6 A flexible move that keeps several plans open: he can play g7-g5 and Bg7, a bold idea that became popular a few years ago; or play g6-Bg7; or simply develop the bishop on its natural square, c5, without White being able to play Bc1-g5. 5. c2c3  5... f8c5  6. b2b4  6... c5e7  7. a2a4  7... d7d6  8. d1b3  8... e8g8  9. e1g1  9... c6b8 The knight returns so that Black can prepare c6-d5. A very difficult move for someone not familiar with this opening, but Nakamura has this very well studied. 10. a4a5  10... c7c6  11. b3a2  11... d6d5  12. c4b3  12... d8c7 Defending the e5-pawn. 13. f1e1  13... f8e8  14. b1d2  14... c8e6  15. c1b2 White's pieces on the queenside make a funny impression. 15... b8d7  16. d2f1  16... e7f8 White has no good plan to improve the position, and he is overextended on the queenside. 17. f3d2 Protecting the pawn on e4 so that the other knight can go to e3. 17... a8d8  18. f1e3  18... b7b5 An excellent move to gain space on the queenside. 19. a5b6  19... a7b6  20. a1d1  20... d8a8  21. a2b1  21... b6b5 Preparing Nb6-a4. Black already has a considerable positional advantage. 22. h2h3  22... a8d8  23. b1a2 Not the best square for the queen, but maybe Nepomniachtchi was counting on a draw by move repetition. 23... d7b6 Of course, Nakamura decides to play on, instead of repeating moves with 23...Ra8. 24. e3f1  24... d8a8  25. a2b1  25... a8d8 