The Poisoned Pawn Variation of the Najdorf was Fischer's and Kasparov's favorite. Computers are not capable of proving an advantage for White, but it takes courage and a good memory to play this line with Black, qualities that Vachier-Lagrave certainly isn't lacking.
1. e2e4  1... c7c5  2. g1f3  2... d7d6  3. d2d4  3... c5d4  4. f3d4  4... g8f6  5. b1c3  5... a7a6  6. c1g5  6... e7e6  7. f2f4 