This is what White's set-up is designed for. And, yes,  Caruana was still blitzing!
1. e2e4  1... c7c5  2. g1f3  2... d7d6  3. d2d4  3... c5d4  4. f3d4  4... g8f6  5. b1c3  5... a7a6  6. c1g5  6... e7e6  7. f2f4  7... d8b6  Vachier-Lagrave lost two painful games in Wijk an Zee earlier this year in the Poisoned Pawn Variation. However, the point of having a reliable  opening repertoire is that despite the occasional cracks, the foundation  will remain solid and one can repair the building relatively fast and  easy. 8. d1d2  8... b6b2  9. a1b1  9... b2a3 The other main direction of the line was  tested by Radjabov recently: 10. e4e5  10... h7h6  11. g5h4  11... d6e5  12. f4e5  12... f6d7  13. c3e4 In this line White often  sacrifices three to four pawns in the blink of an eye: 13... a3a2  14. b1d1  14... a2d5  15. d2e3  15... d5e5  16. c2c3 All of these were confidently blitzed by both the players, but Black's next move came after more than eighteen minutes  on the clock. 16... f8c5  17. h4g3  17... e5d5  18. f1c4 And in a blitz tempo Caruana  bangs a nasty novelty. 18... d5c4  19. g3d6 Without the blink of his other eye, White sacrifices a piece on top the three pawns. All-in-all he is down six fighting units!  Nevertheless, we should not forget that the aim of the game is to  pronounce the enemy king checkmated and material only supports that task. 19... d7f6 Correctly returning a big portion of the material in order to bring the reserves into the play. The main problem for Vachier-Lagrave  was that he had to spend almost half-an hour more from his precious time. 20. e4c5  20... f6d5 This is also needed. The knight blocks the important d-file, but above all prepares the queen swap. 21. e3e5  21... h8g8 Once again, pretty much the only move. Black feels the  position. Vachier-Lagrave practically forces an endgame.