That is a novelty.
1. e2e4  1... e7e5  2. g1f3  2... b8c6  3. f1b5  3... a7a6  4. b5a4  4... g8f6  5. e1g1  5... f6e4 Caruana prepared thoroughly and managed to surprise his opponent with a rare line in the Open Ruy Lopez. 6. d2d4  6... b7b5  7. a4b3  7... d7d5  8. d4e5  8... c8e6  9. c2c3  9... f8c5  10. b1d2  10... e8g8  11. b3c2  11... e4f2 A typical sacrifice in these lines that has been tried by the great Botvinnik against the great Smyslov. 12. f1f2  12... c5f2  13. g1f2  13... f7f6 Black cannot go without this anyway. 14. d2f1 Apparently, White is more successful recently with this move than with 14.exf6. 14... f6e5  15. f2g1  15... d8d7 A surprise for Vachier-Lagrave. Black defends his bishop in advance. 16. c1g5 A good development move, which aims the d5-pawn. 16... a8e8 [Also blitzed by Caruana.]