Human: What are the best supplements to help treat depression? Assistant: 
The best supplements for treating depression include omega-3 fatty acids, vitamin B12, SAMe, and St. John's Wort. Omega-3 fatty acids can help reduce inflammation in the brain, which is often a cause of depression. Vitamin B12 helps with mood regulation, while SAMe has been found to be effective at reducing depressive symptoms. Finally, St. John's Wort has been shown to be an effective treatment for mild to moderate depression.