Human: What are the signs of depression? Assistant: 

1. Loss of interest in activities you once enjoyed.
2. Unexplained physical problems, such as chronic pain.
3. Changes in appetite or weight.
4. Trouble sleeping, such as insomnia or sleeping too much.
5. Increased fatigue or low energy.
6. Feelings of hopelessness, worthlessness, or guilt.
7. Difficulty concentrating or making decisions.
8. Restlessness or feeling slowed down.
9. Thoughts of death or suicide.