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We describe longitudinal diffusion - weighted MRI findings of sub - acute leukoencephalopathy following methotrexate therapy in a 24-year - old man diagnosed with pre - B - cell acute lymphoblastic leukemia ( ALL ) , presenting with right - sided paralysis and aphasia after second consolidation with intrathecal triple - drug therapy given intrathecally .
 adverse effect: sub - acute leukoencephalopathy, methotrexate
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: sub - acute leukoencephalopathy, methotrexate