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1 . Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low - dose alprazolam treatment ( mean 0.62 + /- 0.15 mg / day ) compared with during the period of high - dose period ( mean 1.08 + /- 0.28 mg / day ) .
 adverse effect: Changes in the plasma cortisol level, alprazolam
Given a phrase that describes the relationship between two words, extract the words and the lexical relationship between them. The output format should be "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 adverse effect: Changes in the plasma cortisol level, alprazolam