21513
To ascertain the structure - activity relationship of the core 1 , 2 , 4 - trioxolane substructure of dispiro ozonides OZ277 and OZ439 , we compared the antimalarial activities and ADME profiles of the 1 , 2 - dioxolane , 1 , 2 , 4 - trioxane , and 1 , 2 , 4 , 5 - tetraoxane isosteres .
 Chemical: 1 , 2 , 4 - trioxolane; Chemical: dispiro ozonides; Chemical: OZ277; Chemical: OZ439; Chemical: 1 , 2 - dioxolane; Chemical: 1 , 2 , 4 - trioxane; Chemical: 1 , 2 , 4 , 5 - tetraoxane
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities: 1 , 2 , 4 - trioxolane, dispiro ozonides, OZ277, OZ439, 1 , 2 - dioxolane, 1 , 2 , 4 - trioxane, 1 , 2 , 4 , 5 - tetraoxane 
Answer:
 Chemical: 1 , 2 , 4 - trioxolane; Chemical: dispiro ozonides; Chemical: OZ277; Chemical: OZ439; Chemical: 1 , 2 - dioxolane; Chemical: 1 , 2 , 4 - trioxane; Chemical: 1 , 2 , 4 , 5 - tetraoxane