2552
These findings reveal the differential impact of immune escape variants on the replication and drug susceptibility of complex HBV mutants , supporting the need of close surveillance and treatment adjustment in response to the selection of distinct mutational patterns .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Disease, Chemical 
Text: {0} 
 Entities:  
Answer:
 None