14447
Sirt1 functions as an intracellular energy sensor to detect the concentration of NAD ( + ) , and controls in vivo metabolic changes under caloric restriction and starvation through its deacetylase activity to many targets including histones , nuclear transcriptional factors , and enzymes .
 Chemical: NAD ( + )
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities: NAD ( + ) 
Answer:
 Chemical: NAD ( + )