15660
It has been widely believed that drugs undergoing hydrolysis by hCE1 and hCE2 are not subject to clinically significant alterations in their disposition , but evidence exists that genetic polymorphisms , drug - drug interactions , drug - disease interactions and other factors are important determinants of the variability in the therapeutic response to carboxylesterase - substrate drugs .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities:  
Answer:
 None