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We have cloned and sequenced a portion of the ER upstream regulatory region from the ER -positive MCF-7 and the ER -negative MDA-MB-231 breast cancer cell lines to determine if sequence alterations in this region account for the ER -negative phenotype of some tumors .
 DNA: upstream regulatory region; protein: ER; protein: ER; cell line: ER -positive MCF-7; protein: ER; cell line: ER -negative MDA-MB-231 breast cancer cell lines; protein: ER
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: cell line, protein, RNA, DNA, cell type 
Text: {0} 
 Entities: upstream regulatory region, ER, ER, ER -positive MCF-7, ER, ER -negative MDA-MB-231 breast cancer cell lines, ER 
Answer:
 DNA: upstream regulatory region; protein: ER; protein: ER; cell line: ER -positive MCF-7; protein: ER; cell line: ER -negative MDA-MB-231 breast cancer cell lines; protein: ER