1666
Patient 1 was homozygous for a complex mutant allele containing two alterations , including a 194C > T transition ( P65L ) and 739A > C transversion ( K247Q ) ; in the case of P65L , the amino acid change does not reduce enzyme activity .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
 Entities:  
Answer:
 None