21012
We previously reported that miR - 224 is involved in TGF - beta 1 - mediated follicular granulosa cell ( GC ) growth and estradiol ( E2 ) production by targeting Smad4 .
 Chemical: estradiol
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities: estradiol 
Answer:
 Chemical: estradiol