11635
In addition , we found that miR - 22 suppresses interferon gene expression by directly targeting high mobility group box - 1 and interferon regulatory factor ( IRF ) - 5 , preventing activation of IRF3 and NF - kappa B , which are activators of interferon genes .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities:  
Answer:
 None