2147
However , a comparison of the data suggested that both missense and synonymous mutations can occur at any coding sequence of the human germ line HPRT gene , but that a limited percentage of all the missense mutations cause disease .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Disease 
Text: {0} 
 Entities:  
Answer:
 None