16992
Consequently , the pharmacopoeia for majority of these diseases , composed mainly of agents with poor efficacy and unsatisfactory safety profiles , has essentially remained unchanged for decades , creating a compelling need for more efficacious and better tolerated medicines .
 None
Given options, please tell me the categories of all the listed entity words.Output format is "type1: word1; type2: word2". 
Option: Chemical 
Text: {0} 
 Entities:  
Answer:
 None