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there were setbacks and technical problems that ensued from the location design , flooding , and moisture that plagued the winery and bumped up the investment cost beyond the initial budgetary estimates .
 cause effect: setbacks, design
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: component whole, NA, instrument agency, member collection, cause effect, entity destination, content container, message topic, product producer, entity origin 
Text: {0} 
 Entity Pairs:  setbacks, design 
Answer:
 cause effect: setbacks, design