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Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis , in which a cutaneous local immune - mediated inflammatory process might be involved .
 adverse effect: Cutaneous necrosis, interferon alfa
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  Cutaneous necrosis, interferon alfa 
Answer:
 adverse effect: Cutaneous necrosis, interferon alfa