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DISCUSSION : The main adverse effects of leflunomide consist of diarrhea , nausea , liver enzyme elevation , hypertension , alopecia , and allergic skin reactions .
 adverse effect: allergic skin reactions, leflunomide; adverse effect: alopecia, leflunomide; adverse effect: diarrhea, leflunomide; adverse effect: hypertension, leflunomide; adverse effect: liver enzyme elevation, leflunomide; adverse effect: nausea, leflunomide
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  allergic skin reactions, leflunomide; alopecia, leflunomide; diarrhea, leflunomide; hypertension, leflunomide; liver enzyme elevation, leflunomide; nausea, leflunomide 
Answer:
 adverse effect: allergic skin reactions, leflunomide; adverse effect: alopecia, leflunomide; adverse effect: diarrhea, leflunomide; adverse effect: hypertension, leflunomide; adverse effect: liver enzyme elevation, leflunomide; adverse effect: nausea, leflunomide