6611
OBSERVATIONS : We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll - like receptor ( TLR ) 7 agonist imiquimod .
 adverse effect: aggravation and spreading of a psoriatic plaque, imiquimod
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  aggravation and spreading of a psoriatic plaque, imiquimod 
Answer:
 adverse effect: aggravation and spreading of a psoriatic plaque, imiquimod