6489
This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy .
 adverse effect: fatal encephalopathy, methotrexate; adverse effect: mild neurotoxicity, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  fatal encephalopathy, methotrexate; mild neurotoxicity, methotrexate 
Answer:
 adverse effect: fatal encephalopathy, methotrexate; adverse effect: mild neurotoxicity, methotrexate