5912
Metformin - associated lactic acidosis ( MALA ) is a serious metabolic complication that occurs because of metformin accumulation in patients who become dehydrated or developed acute renal failure .
 adverse effect: lactic acidosis, metformin; adverse effect: lactic acidosis, Metformin
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  lactic acidosis, metformin; lactic acidosis, Metformin 
Answer:
 adverse effect: lactic acidosis, metformin; adverse effect: lactic acidosis, Metformin