7918
CONCLUSIONS : Prolonged exposure to itraconazole , administered either continuously or intermittently , may precipitate severe and irreversible hepatotoxic events .
 adverse effect: severe and irreversible hepatotoxic events, itraconazole
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  severe and irreversible hepatotoxic events, itraconazole 
Answer:
 adverse effect: severe and irreversible hepatotoxic events, itraconazole