12213
Flutamide withdrawal syndrome is characterized by a decrease in prostate - specific antigen ( PSA ) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate .
 adverse effect: decrease in prostate - specific antigen, Flutamide; adverse effect: decrease in prostate - specific antigen, flutamide; adverse effect: Flutamide withdrawal syndrome, Flutamide; adverse effect: Flutamide withdrawal syndrome, flutamide
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  decrease in prostate - specific antigen, Flutamide; decrease in prostate - specific antigen, flutamide; Flutamide withdrawal syndrome, Flutamide; Flutamide withdrawal syndrome, flutamide 
Answer:
 adverse effect: decrease in prostate - specific antigen, Flutamide; adverse effect: decrease in prostate - specific antigen, flutamide; adverse effect: Flutamide withdrawal syndrome, Flutamide; adverse effect: Flutamide withdrawal syndrome, flutamide