6507
Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and , in some patients with CML , imatinib may promote cytogenetic clonal evolution , resulting in a poor response to treatment .
 adverse effect: progression of marrow reticulin fibrosis, imatinib
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  progression of marrow reticulin fibrosis, imatinib 
Answer:
 adverse effect: progression of marrow reticulin fibrosis, imatinib