11219
Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression .
 adverse effect: bone marrow suppression, methotrexate; adverse effect: methotrexate toxicity, methotrexate; adverse effect: Painful erosion of psoriatic plaques, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  bone marrow suppression, methotrexate; methotrexate toxicity, methotrexate; Painful erosion of psoriatic plaques, methotrexate 
Answer:
 adverse effect: bone marrow suppression, methotrexate; adverse effect: methotrexate toxicity, methotrexate; adverse effect: Painful erosion of psoriatic plaques, methotrexate