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Six of 13 outpatients with schizophrenia who participated in a ten - week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect , including feelings of agitation and depression and periods of crying and insomnia .
 adverse effect: depression, risperidone; adverse effect: feelings of agitation, risperidone; adverse effect: insomnia, risperidone; adverse effect: intolerable affect, risperidone; adverse effect: periods of crying, risperidone
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  depression, risperidone; feelings of agitation, risperidone; insomnia, risperidone; intolerable affect, risperidone; periods of crying, risperidone 
Answer:
 adverse effect: depression, risperidone; adverse effect: feelings of agitation, risperidone; adverse effect: insomnia, risperidone; adverse effect: intolerable affect, risperidone; adverse effect: periods of crying, risperidone