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A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days , respectively , following a single dose of 40 mg / m2 methotrexate ( MTX ) .
 adverse effect: bone marrow aplasia, methotrexate; adverse effect: bone marrow aplasia, MTX; adverse effect: severe skin rash, methotrexate; adverse effect: severe skin rash, MTX
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  bone marrow aplasia, methotrexate; bone marrow aplasia, MTX; severe skin rash, methotrexate; severe skin rash, MTX 
Answer:
 adverse effect: bone marrow aplasia, methotrexate; adverse effect: bone marrow aplasia, MTX; adverse effect: severe skin rash, methotrexate; adverse effect: severe skin rash, MTX