3015
In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity , even at lower doses , which resulted in two drug - related deaths .
 adverse effect: severe hepatotoxicity, hycanthone
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  severe hepatotoxicity, hycanthone 
Answer:
 adverse effect: severe hepatotoxicity, hycanthone