8313
A 75-year - old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone .
 adverse effect: bilateral lower leg edema, pioglitazone
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  bilateral lower leg edema, pioglitazone 
Answer:
 adverse effect: bilateral lower leg edema, pioglitazone