1833
A 66-year - old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D - penicillamine ( D - Pen ) treatment , although the leukopenia was not markedly severe .
 adverse effect: anemia, D - Pen; adverse effect: anemia, D - penicillamine; adverse effect: thrombocytopenia, D - Pen; adverse effect: thrombocytopenia, D - penicillamine
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  anemia, D - Pen; anemia, D - penicillamine; thrombocytopenia, D - Pen; thrombocytopenia, D - penicillamine 
Answer:
 adverse effect: anemia, D - Pen; adverse effect: anemia, D - penicillamine; adverse effect: thrombocytopenia, D - Pen; adverse effect: thrombocytopenia, D - penicillamine