11605
Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient - years up to February 1978 .
 adverse effect: acute leukemia, Treosulfan
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  acute leukemia, Treosulfan 
Answer:
 adverse effect: acute leukemia, Treosulfan