13758
One explanation for the noted increase in the theophylline level is that metabolism occurs mainly by cytochrome P450 ( CYP 1A2 ) , an enzyme that is known to be inhibited with high concentrations of zafirlukast .
 adverse effect: increase in the theophylline level, theophylline; adverse effect: increase in the theophylline level, zafirlukast
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  increase in the theophylline level, theophylline; increase in the theophylline level, zafirlukast 
Answer:
 adverse effect: increase in the theophylline level, theophylline; adverse effect: increase in the theophylline level, zafirlukast