3065
The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect .
 adverse effect: severe restrictive ventilatory defect, cyclophosphamide
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  severe restrictive ventilatory defect, cyclophosphamide 
Answer:
 adverse effect: severe restrictive ventilatory defect, cyclophosphamide