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Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss .
 adverse effect: sensorineural hearing loss, methotrexate; adverse effect: sensorineural hearing loss, PAN
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  sensorineural hearing loss, methotrexate; sensorineural hearing loss, PAN 
Answer:
 adverse effect: sensorineural hearing loss, methotrexate; adverse effect: sensorineural hearing loss, PAN