8472
In this report , two newborns with congenital heart anomalies demonstrated the harlequin color change , one whose skin findings showed a course related to the dose of systemic prostaglandin E1 , suggesting a possible association .
 adverse effect: harlequin color change, prostaglandin E1
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  harlequin color change, prostaglandin E1 
Answer:
 adverse effect: harlequin color change, prostaglandin E1