11092
We highlight two instances of systemic allergic reaction , and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use .
 adverse effect: systemic allergic reaction, aprotinin
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  systemic allergic reaction, aprotinin 
Answer:
 adverse effect: systemic allergic reaction, aprotinin