438
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV - associated lymphoproliferative disease .
 adverse effect: EBV - associated lymphoproliferative disease, MTX; adverse effect: hematopoietic toxicity, MTX; adverse effect: immunosuppression, MTX
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  EBV - associated lymphoproliferative disease, MTX; hematopoietic toxicity, MTX; immunosuppression, MTX 
Answer:
 adverse effect: EBV - associated lymphoproliferative disease, MTX; adverse effect: hematopoietic toxicity, MTX; adverse effect: immunosuppression, MTX