1348
CONCLUSIONS : Itraconazole - induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts , possibly leading to ductopenia .
 adverse effect: cholestatic pattern of injury, Itraconazole; adverse effect: damage to the interlobular bile ducts, Itraconazole; adverse effect: ductopenia, Itraconazole; adverse effect: liver injury, Itraconazole
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  cholestatic pattern of injury, Itraconazole; damage to the interlobular bile ducts, Itraconazole; ductopenia, Itraconazole; liver injury, Itraconazole 
Answer:
 adverse effect: cholestatic pattern of injury, Itraconazole; adverse effect: damage to the interlobular bile ducts, Itraconazole; adverse effect: ductopenia, Itraconazole; adverse effect: liver injury, Itraconazole