12109
Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment , but conversely has prolonged effects in hepatic failure .
 adverse effect: hepatic failure, Argatroban
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  hepatic failure, Argatroban 
Answer:
 adverse effect: hepatic failure, Argatroban