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One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment , none of which was clinically significant .
 adverse effect: lower average heart rate, propranolol; adverse effect: lower average mean blood pressure, propranolol
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  lower average heart rate, propranolol; lower average mean blood pressure, propranolol 
Answer:
 adverse effect: lower average heart rate, propranolol; adverse effect: lower average mean blood pressure, propranolol