5436
A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate .
 adverse effect: brainstem herniation, methotrexate; adverse effect: fatal cerebral edema, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  brainstem herniation, methotrexate; fatal cerebral edema, methotrexate 
Answer:
 adverse effect: brainstem herniation, methotrexate; adverse effect: fatal cerebral edema, methotrexate