3046
Three patients , in whom tumour overkill by cytotoxic treatment , including high dose methotrexate with folinic acid rescue , resulted in the ' phosphate shower syndrome ' ( hyper - uricaemia , hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany , with metabolic acidosis and acute renal impairment ) are described .
 adverse effect: acute renal impairment, folinic acid; adverse effect: acute renal impairment, methotrexate; adverse effect: hyperkalaemia, folinic acid; adverse effect: hyperkalaemia, methotrexate; adverse effect: hyperphosphataemia, folinic acid; adverse effect: hyperphosphataemia, methotrexate; adverse effect: hyper - uricaemia, folinic acid; adverse effect: hyper - uricaemia, methotrexate; adverse effect: hypocalcaemia, folinic acid; adverse effect: hypocalcaemia, methotrexate; adverse effect: metabolic acidosis, folinic acid; adverse effect: metabolic acidosis, methotrexate; adverse effect: phosphate shower syndrome, folinic acid; adverse effect: phosphate shower syndrome, methotrexate; adverse effect: tetany, folinic acid; adverse effect: tetany, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  acute renal impairment, folinic acid; acute renal impairment, methotrexate; hyperkalaemia, folinic acid; hyperkalaemia, methotrexate; hyperphosphataemia, folinic acid; hyperphosphataemia, methotrexate; hyper - uricaemia, folinic acid; hyper - uricaemia, methotrexate; hypocalcaemia, folinic acid; hypocalcaemia, methotrexate; metabolic acidosis, folinic acid; metabolic acidosis, methotrexate; phosphate shower syndrome, folinic acid; phosphate shower syndrome, methotrexate; tetany, folinic acid; tetany, methotrexate 
Answer:
 adverse effect: acute renal impairment, folinic acid; adverse effect: acute renal impairment, methotrexate; adverse effect: hyperkalaemia, folinic acid; adverse effect: hyperkalaemia, methotrexate; adverse effect: hyperphosphataemia, folinic acid; adverse effect: hyperphosphataemia, methotrexate; adverse effect: hyper - uricaemia, folinic acid; adverse effect: hyper - uricaemia, methotrexate; adverse effect: hypocalcaemia, folinic acid; adverse effect: hypocalcaemia, methotrexate; adverse effect: metabolic acidosis, folinic acid; adverse effect: metabolic acidosis, methotrexate; adverse effect: phosphate shower syndrome, folinic acid; adverse effect: phosphate shower syndrome, methotrexate; adverse effect: tetany, folinic acid; adverse effect: tetany, methotrexate