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Although they had only a few nodules at diagnosis , the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients .
 adverse effect: nodules, methotrexate; adverse effect: nodules, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  nodules, methotrexate; nodules, methotrexate 
Answer:
 adverse effect: nodules, methotrexate; adverse effect: nodules, methotrexate