2480
Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years .
 adverse effect: Progressive interstitial fibrosis, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  Progressive interstitial fibrosis, methotrexate 
Answer:
 adverse effect: Progressive interstitial fibrosis, methotrexate