7080
To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy , we conducted a retrospective survey of 25 additional patients with Wilson 's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine .
 adverse effect: neurologic disease, penicillamine; adverse effect: neurologic worsening, penicillamine
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  neurologic disease, penicillamine; neurologic worsening, penicillamine 
Answer:
 adverse effect: neurologic disease, penicillamine; adverse effect: neurologic worsening, penicillamine