1646
A 33-year - old male presented with brown discolouration of the fingernails following the application of 4 % hydroquinone in sorbolene cream and 0.1 % tretinoin cream to the face intermittently for 9 months .
 adverse effect: brown discolouration of the fingernails, 0.1 % tretinoin cream; adverse effect: brown discolouration of the fingernails, 4 % hydroquinone in sorbolene cream
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  brown discolouration of the fingernails, 0.1 % tretinoin cream; brown discolouration of the fingernails, 4 % hydroquinone in sorbolene cream 
Answer:
 adverse effect: brown discolouration of the fingernails, 0.1 % tretinoin cream; adverse effect: brown discolouration of the fingernails, 4 % hydroquinone in sorbolene cream