13827
The pathophysiological mechanisms remain unknown , although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab .
 adverse effect: destruction of CD20 positive cells, rituximab; adverse effect: massive cytokines liberation, rituximab
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  destruction of CD20 positive cells, rituximab; massive cytokines liberation, rituximab 
Answer:
 adverse effect: destruction of CD20 positive cells, rituximab; adverse effect: massive cytokines liberation, rituximab