3000
CONCLUSION : Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow - up of patients on topical brimonidine .
 adverse effect: paradoxical raised IOP, brimonidine
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  paradoxical raised IOP, brimonidine 
Answer:
 adverse effect: paradoxical raised IOP, brimonidine