1404
OBJECTIVE : The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment , and to describe a successful therapeutic approach using imiquimod 5 % .
 adverse effect: diffuse nail hyperpigmentation, hydroxyurea; adverse effect: multiple squamous cell carcinomas, hydroxyurea
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  diffuse nail hyperpigmentation, hydroxyurea; multiple squamous cell carcinomas, hydroxyurea 
Answer:
 adverse effect: diffuse nail hyperpigmentation, hydroxyurea; adverse effect: multiple squamous cell carcinomas, hydroxyurea