747
The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis , and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities , the combination use of these drugs should be avoided .
 adverse effect: fatal toxicities, itraconazole; adverse effect: fatal toxicities, vincristine
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  fatal toxicities, itraconazole; fatal toxicities, vincristine 
Answer:
 adverse effect: fatal toxicities, itraconazole; adverse effect: fatal toxicities, vincristine