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A patient with chronic myeloid leukaemia treated with busulphan for 4 - 5 years , developed signs of busulphan toxicity and portal hypertension with ascites , oesophageal varices and jaundice .
 adverse effect: ascites, busulphan; adverse effect: jaundice, busulphan; adverse effect: oesophageal varices, busulphan; adverse effect: portal hypertension, busulphan
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  ascites, busulphan; jaundice, busulphan; oesophageal varices, busulphan; portal hypertension, busulphan 
Answer:
 adverse effect: ascites, busulphan; adverse effect: jaundice, busulphan; adverse effect: oesophageal varices, busulphan; adverse effect: portal hypertension, busulphan