2948
When the acute manic state is characterized by marked psychotic symptoms and intense anxiety , it may be associated with increased vulnerability to the development of severe lithium neurotoxicity .
 adverse effect: intense anxiety, lithium; adverse effect: neurotoxicity, lithium; adverse effect: psychotic symptoms, lithium
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  intense anxiety, lithium; neurotoxicity, lithium; psychotic symptoms, lithium 
Answer:
 adverse effect: intense anxiety, lithium; adverse effect: neurotoxicity, lithium; adverse effect: psychotic symptoms, lithium