6899
Potential causes of methamphetamine - related keratitis can be divided into four categories resulting from ( a ) direct pharmacologic and physical effects of methamphetamine ; ( b ) the toxic effects of diluting or " cutting " agents such as lidocaine and quinine ; ( c ) effects related to the route of drug administration ( intravenous , inhalation , smoking ) ; and ( d ) manufacture - related effects of exposure to unintentional caustic contaminants in the final product .
 adverse effect: keratitis, lidocaine; adverse effect: keratitis, methamphetamine; adverse effect: keratitis, quinine; adverse effect: toxic effects, lidocaine; adverse effect: toxic effects, methamphetamine; adverse effect: toxic effects, quinine
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  keratitis, lidocaine; keratitis, methamphetamine; keratitis, quinine; toxic effects, lidocaine; toxic effects, methamphetamine; toxic effects, quinine 
Answer:
 adverse effect: keratitis, lidocaine; adverse effect: keratitis, methamphetamine; adverse effect: keratitis, quinine; adverse effect: toxic effects, lidocaine; adverse effect: toxic effects, methamphetamine; adverse effect: toxic effects, quinine