11933
Methotrexate - associated nephropathy is a rare complication in pediatric oncology , and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development .
 adverse effect: nephropathy, Methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  nephropathy, Methotrexate 
Answer:
 adverse effect: nephropathy, Methotrexate