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Contrary to previous recommendations , our experience cautions against the further use of high - dose cytarabine in patients who develop PPE , and is a timely reminder of the potential toxicity of this agent , which is now increasingly being used as first - line treatment in the management of haematologic malignancies .
 adverse effect: PPE, cytarabine
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  PPE, cytarabine 
Answer:
 adverse effect: PPE, cytarabine