2945
There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density , increase in the incidence of all bone fractures ( especially fractures of spine , hip and wrist ) , joint disorders and increase in the cholesterol level .
 adverse effect: decrease in both lumbar spine, anastrozole; adverse effect: increase in the cholesterol level, anastrozole; adverse effect: increase in the incidence of all bone fractures, anastrozole; adverse effect: joint disorders, anastrozole
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  decrease in both lumbar spine, anastrozole; increase in the cholesterol level, anastrozole; increase in the incidence of all bone fractures, anastrozole; joint disorders, anastrozole 
Answer:
 adverse effect: decrease in both lumbar spine, anastrozole; adverse effect: increase in the cholesterol level, anastrozole; adverse effect: increase in the incidence of all bone fractures, anastrozole; adverse effect: joint disorders, anastrozole