9854
CASE : We present an 11-year old male with Budd - Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus .
 adverse effect: worsening of chronic aphthous ulcers, sirolimus; adverse effect: worsening of chronic aphthous ulcers, tacrolimus
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  worsening of chronic aphthous ulcers, sirolimus; worsening of chronic aphthous ulcers, tacrolimus 
Answer:
 adverse effect: worsening of chronic aphthous ulcers, sirolimus; adverse effect: worsening of chronic aphthous ulcers, tacrolimus