1409
We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature , emphasizing the risk factors associated with this manifestation .
 adverse effect: methotrexate toxicity, methotrexate; adverse effect: painful erosions of their psoriasis, methotrexate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  methotrexate toxicity, methotrexate; painful erosions of their psoriasis, methotrexate 
Answer:
 adverse effect: methotrexate toxicity, methotrexate; adverse effect: painful erosions of their psoriasis, methotrexate