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A 53-year - old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once / day to 4 mg twice / day .
 adverse effect: lower leg edema, rosiglitazone
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  lower leg edema, rosiglitazone 
Answer:
 adverse effect: lower leg edema, rosiglitazone