4927
Four patients receiving high - dose tamoxifen for greater than 1 year have demonstrated similar retinal changes .
 adverse effect: retinal changes, tamoxifen
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  retinal changes, tamoxifen 
Answer:
 adverse effect: retinal changes, tamoxifen