12322
Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus .
 adverse effect: gastrointestinal adverse reactions, Ibuprofen
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  gastrointestinal adverse reactions, Ibuprofen 
Answer:
 adverse effect: gastrointestinal adverse reactions, Ibuprofen