1471
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life - threatening bone marrow aplasia .
 adverse effect: extensive skin rash, MTX
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  extensive skin rash, MTX 
Answer:
 adverse effect: extensive skin rash, MTX