3252
To our knowledge , these cases represent the first reports of TDF - associated irreversible renal failure and rickets in pediatric patients .
 adverse effect: irreversible renal failure, TDF; adverse effect: rickets, TDF
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  irreversible renal failure, TDF; rickets, TDF 
Answer:
 adverse effect: irreversible renal failure, TDF; adverse effect: rickets, TDF