12278
Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy .
 adverse effect: Hypoxia, indomethacin; adverse effect: premature ductal closure, indomethacin
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  Hypoxia, indomethacin; premature ductal closure, indomethacin 
Answer:
 adverse effect: Hypoxia, indomethacin; adverse effect: premature ductal closure, indomethacin