12503
We discuss a patient who developed severe renal tubular dysfunction secondary to short - term therapy with Amikacin , resulting in refractory hypokalemia , hypocalcemia , hypomagnesemia , metabolic alkalosis , and polyuria .
 adverse effect: hypocalcemia, Amikacin; adverse effect: hypomagnesemia, Amikacin; adverse effect: metabolic alkalosis, Amikacin; adverse effect: polyuria, Amikacin; adverse effect: refractory hypokalemia, Amikacin; adverse effect: severe renal tubular dysfunction, Amikacin
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  hypocalcemia, Amikacin; hypomagnesemia, Amikacin; metabolic alkalosis, Amikacin; polyuria, Amikacin; refractory hypokalemia, Amikacin; severe renal tubular dysfunction, Amikacin 
Answer:
 adverse effect: hypocalcemia, Amikacin; adverse effect: hypomagnesemia, Amikacin; adverse effect: metabolic alkalosis, Amikacin; adverse effect: polyuria, Amikacin; adverse effect: refractory hypokalemia, Amikacin; adverse effect: severe renal tubular dysfunction, Amikacin