5114
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment .
 adverse effect: longitudinal melanonychia, hydroxyurea; adverse effect: multiple skin cancers, hydroxyurea
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  longitudinal melanonychia, hydroxyurea; multiple skin cancers, hydroxyurea 
Answer:
 adverse effect: longitudinal melanonychia, hydroxyurea; adverse effect: multiple skin cancers, hydroxyurea