12126
To our knowledge , this is the first granulomatous reaction described after calcium hydroxylapatite injection .
 adverse effect: granulomatous reaction, calcium hydroxylapatite
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  granulomatous reaction, calcium hydroxylapatite 
Answer:
 adverse effect: granulomatous reaction, calcium hydroxylapatite