3047
We describe two dark - skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin .
 adverse effect: hyperpigmented skin, IFN; adverse effect: hyperpigmented skin, ribavirin; adverse effect: tongue lesions, IFN; adverse effect: tongue lesions, ribavirin
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  hyperpigmented skin, IFN; hyperpigmented skin, ribavirin; tongue lesions, IFN; tongue lesions, ribavirin 
Answer:
 adverse effect: hyperpigmented skin, IFN; adverse effect: hyperpigmented skin, ribavirin; adverse effect: tongue lesions, IFN; adverse effect: tongue lesions, ribavirin