2251
In one patient the vasculitis resolved after termination of the ciprofloxacin therapy ; in the other patient the ciprofloxacin - induced hemorrhagic vasculitis was superimposed on a severe forefoot infection , leading to progressive gangrene and a below - knee amputation .
 adverse effect: below - knee amputation, ciprofloxacin; adverse effect: hemorrhagic vasculitis, ciprofloxacin; adverse effect: progressive gangrene, ciprofloxacin; adverse effect: severe forefoot infection, ciprofloxacin; adverse effect: vasculitis, ciprofloxacin
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  below - knee amputation, ciprofloxacin; hemorrhagic vasculitis, ciprofloxacin; progressive gangrene, ciprofloxacin; severe forefoot infection, ciprofloxacin; vasculitis, ciprofloxacin 
Answer:
 adverse effect: below - knee amputation, ciprofloxacin; adverse effect: hemorrhagic vasculitis, ciprofloxacin; adverse effect: progressive gangrene, ciprofloxacin; adverse effect: severe forefoot infection, ciprofloxacin; adverse effect: vasculitis, ciprofloxacin