3415
The administration of " sweet spirits of nitre " ( 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol ) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins , Methylene blue administration reversed methemoglobinemia in both , but one twin died from the consequences of hypoxemia .
 adverse effect: acute methemoglobinemia, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: acute methemoglobinemia, sweet spirits of nitre; adverse effect: died, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: died, sweet spirits of nitre; adverse effect: hypoxemia, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: hypoxemia, sweet spirits of nitre; adverse effect: severe anoxic metabolic acidosis, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: severe anoxic metabolic acidosis, sweet spirits of nitre
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  acute methemoglobinemia, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; acute methemoglobinemia, sweet spirits of nitre; died, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; died, sweet spirits of nitre; hypoxemia, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; hypoxemia, sweet spirits of nitre; severe anoxic metabolic acidosis, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; severe anoxic metabolic acidosis, sweet spirits of nitre 
Answer:
 adverse effect: acute methemoglobinemia, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: acute methemoglobinemia, sweet spirits of nitre; adverse effect: died, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: died, sweet spirits of nitre; adverse effect: hypoxemia, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: hypoxemia, sweet spirits of nitre; adverse effect: severe anoxic metabolic acidosis, 4 % ethyl nitrite CH3CH2ONO in 70 % ethyl alcohol; adverse effect: severe anoxic metabolic acidosis, sweet spirits of nitre