2113
In case 1 , a total daily dose of 25 mg sertraline , with nondetectable sertraline and desmethylsertraline blood levels , resulted in a doubling of the lamotrigine blood level with symptoms of toxicity .
 adverse effect: doubling of the lamotrigine blood level, desmethylsertraline; adverse effect: doubling of the lamotrigine blood level, lamotrigine; adverse effect: doubling of the lamotrigine blood level, sertraline; adverse effect: doubling of the lamotrigine blood level, sertraline; adverse effect: symptoms of toxicity, desmethylsertraline; adverse effect: symptoms of toxicity, lamotrigine; adverse effect: symptoms of toxicity, sertraline; adverse effect: symptoms of toxicity, sertraline
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  doubling of the lamotrigine blood level, desmethylsertraline; doubling of the lamotrigine blood level, lamotrigine; doubling of the lamotrigine blood level, sertraline; doubling of the lamotrigine blood level, sertraline; symptoms of toxicity, desmethylsertraline; symptoms of toxicity, lamotrigine; symptoms of toxicity, sertraline; symptoms of toxicity, sertraline 
Answer:
 adverse effect: doubling of the lamotrigine blood level, desmethylsertraline; adverse effect: doubling of the lamotrigine blood level, lamotrigine; adverse effect: doubling of the lamotrigine blood level, sertraline; adverse effect: doubling of the lamotrigine blood level, sertraline; adverse effect: symptoms of toxicity, desmethylsertraline; adverse effect: symptoms of toxicity, lamotrigine; adverse effect: symptoms of toxicity, sertraline; adverse effect: symptoms of toxicity, sertraline