7825
The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued , and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication .
 adverse effect: amenorrhea, valproate; adverse effect: gained weight, valproate; adverse effect: polycystic changes, valproate
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  amenorrhea, valproate; gained weight, valproate; polycystic changes, valproate 
Answer:
 adverse effect: amenorrhea, valproate; adverse effect: gained weight, valproate; adverse effect: polycystic changes, valproate