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However , we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function .
 adverse effect: toxic optic neuropathies, ethambutol; adverse effect: visual loss, ethambutol
Given options, please tell me the relationships of all the listed entity pairs.Output format is "relation1: word1, word2; relation2: word3, word4". 
Option: adverse effect 
Text: {0} 
 Entity Pairs:  toxic optic neuropathies, ethambutol; visual loss, ethambutol 
Answer:
 adverse effect: toxic optic neuropathies, ethambutol; adverse effect: visual loss, ethambutol