8720
The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate .
 encephalopathy, methotrexate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 encephalopathy, methotrexate