4233
OBJECTIVE : To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center .
 weight loss, leflunomide
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 weight loss, leflunomide