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Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss .
 sensorineural hearing loss, methotrexate; sensorineural hearing loss, PAN
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 sensorineural hearing loss, methotrexate; sensorineural hearing loss, PAN