5335
A female patient with HER2 positive , metastatic breast cancer presented with pulmonary infiltrates , and a plural effusion dyspnoea after several months of trastuzumab treatment .
 plural effusion dyspnoea, trastuzumab; pulmonary infiltrates, trastuzumab
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 plural effusion dyspnoea, trastuzumab; pulmonary infiltrates, trastuzumab