4363
Although they had only a few nodules at diagnosis , the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients .
 nodules, methotrexate; nodules, methotrexate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 nodules, methotrexate; nodules, methotrexate