7463
Grade 3 hepatotoxicity ( AST and ALT > 5 to 20 upper limit normal ) or higher has been observed in as many as 1.4 % of MS patients on IFN beta .
 Grade 3 hepatotoxicity, IFN beta
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 Grade 3 hepatotoxicity, IFN beta