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Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and , in some patients with CML , imatinib may promote cytogenetic clonal evolution , resulting in a poor response to treatment .
 progression of marrow reticulin fibrosis, imatinib
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 progression of marrow reticulin fibrosis, imatinib