4124
After therapy with parenteral amiodarone ( 2300 mg in 3 days ) and other measures , signs of congestive heart failure disappeared ; subsequently the patient developed jaundice , marked increase in serum transaminase levels and fall in prothrombin time , and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy .
 fall in prothrombin time, amiodarone; jaundice, amiodarone; marked increase in serum transaminase levels, amiodarone; severe centrilobular necrosis, amiodarone
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 fall in prothrombin time, amiodarone; jaundice, amiodarone; marked increase in serum transaminase levels, amiodarone; severe centrilobular necrosis, amiodarone