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The toxic effects of methotrexate included elevated liver transaminases ( 3/4 ) , nausea ( 2/4 ) , abdominal pain ( 2/4 ) , bone pain ( 2/4 ) , mild neutropenia ( 1/4 ) , and mild pruritus ( 1/4 ) .
 abdominal pain, methotrexate; bone pain, methotrexate; elevated liver transaminases, methotrexate; mild neutropenia, methotrexate; mild pruritus, methotrexate; nausea, methotrexate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 abdominal pain, methotrexate; bone pain, methotrexate; elevated liver transaminases, methotrexate; mild neutropenia, methotrexate; mild pruritus, methotrexate; nausea, methotrexate