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A woman 38-year - old , suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo - Medrol , developed a spastic paraparesis at the lower limbs .
 spastic paraparesis at the lower limbs, Depo - Medrol
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 spastic paraparesis at the lower limbs, Depo - Medrol