2942
Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period , while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred .
 brain lesions, penicillamine
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 brain lesions, penicillamine