9798
A 53-year - old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once / day to 4 mg twice / day .
 lower leg edema, rosiglitazone
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 lower leg edema, rosiglitazone