8640
Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects , including premature closure of the ductus arteriosus .
 premature closure of the ductus arteriosus, indomethacin
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 premature closure of the ductus arteriosus, indomethacin