3786
Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted .
 increased pigmementation of skin, 5-fluorouracil
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 increased pigmementation of skin, 5-fluorouracil