1988
We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d - penicillamine 125 - 500 mg daily .
 acute generalized dystonia, d - penicillamine; akinetic rigid syndrome, d - penicillamine
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 acute generalized dystonia, d - penicillamine; akinetic rigid syndrome, d - penicillamine