4392
OBJECTIVES : To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib .
 lower gastrointestinal symptoms, rofecoxib
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 lower gastrointestinal symptoms, rofecoxib