4011
Careful follow - up of so - called " self - limited " insulin edema is encouraged , and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure .
 edema, insulin
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 edema, insulin