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We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low - molecular weight heparin therapy at sites distant from injection sites .
 skin necrosis, low - molecular weight heparin
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 skin necrosis, low - molecular weight heparin