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A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year - old woman .
 toxic hepatitis, etretinate; toxic hepatitis, methotrexate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 toxic hepatitis, etretinate; toxic hepatitis, methotrexate