11456
Animals treated with HAL showed a highly significant 32%-46 % loss of tyrosine hydroxylase ( TH ) immunoreactive neurons in the substantia nigra , and 20 % contraction of the TH stained dendritic arbour .
 significant 32%-46 % loss of tyrosine hydroxylase ( TH ) immunoreactive neurons, HAL
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 significant 32%-46 % loss of tyrosine hydroxylase ( TH ) immunoreactive neurons, HAL