8684
A 75-year - old man developed bilateral lower leg edema 6 months after switching from troglitazone to pioglitazone .
 bilateral lower leg edema, pioglitazone
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 bilateral lower leg edema, pioglitazone