3841
PURPOSE : To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant .
 central nervous system depression, brimonidine
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 central nervous system depression, brimonidine