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Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy .
 Hypoxia, indomethacin; premature ductal closure, indomethacin
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 Hypoxia, indomethacin; premature ductal closure, indomethacin