754
The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued , and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication .
 amenorrhea, valproate; gained weight, valproate; polycystic changes, valproate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 amenorrhea, valproate; gained weight, valproate; polycystic changes, valproate