13758
One explanation for the noted increase in the theophylline level is that metabolism occurs mainly by cytochrome P450 ( CYP 1A2 ) , an enzyme that is known to be inhibited with high concentrations of zafirlukast .
 increase in the theophylline level, theophylline; increase in the theophylline level, zafirlukast
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 increase in the theophylline level, theophylline; increase in the theophylline level, zafirlukast