14175
We describe a patient with CREST syndrome ( calcinosis , Raynaud 's phenomenon , esophageal dysfunction , sclerodactyly , and telangiectasia ) who paradoxically experienced worsening of Raynaud 's phenomenon when using yohimbine for ED .
 worsening of Raynaud 's phenomenon, yohimbine
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 worsening of Raynaud 's phenomenon, yohimbine