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CONCLUSIONS : Prolonged exposure to itraconazole , administered either continuously or intermittently , may precipitate severe and irreversible hepatotoxic events .
 severe and irreversible hepatotoxic events, itraconazole
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 severe and irreversible hepatotoxic events, itraconazole