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We describe a 57-year - old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy ( bleomycin and methotrexate ) used to treat a metastatic squamous cell carcinoma of the hypopharynx .
 acute digital ischemia, bleomycin; acute digital ischemia, methotrexate; gangrene, bleomycin; gangrene, methotrexate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 acute digital ischemia, bleomycin; acute digital ischemia, methotrexate; gangrene, bleomycin; gangrene, methotrexate