2078
Although high - dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma , the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure .
 fatal rise in intracranial pressure, methotrexate
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 fatal rise in intracranial pressure, methotrexate