4008
After only the third dose of pentamidine , it was noted that the patient 's heart rate had decreased to 48 beats / minute .
 heart rate had decreased, pentamidine
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 heart rate had decreased, pentamidine