985
It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine , leading to increased serum lamotrigine levels , or perhaps alter the drug 's metabolism , resulting in accumulation of a toxic intermediate metabolite .
 accumulation of a toxic intermediate metabolite, lamotrigine; accumulation of a toxic intermediate metabolite, valproic acid; increased serum lamotrigine levels, lamotrigine; increased serum lamotrigine levels, valproic acid
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 accumulation of a toxic intermediate metabolite, lamotrigine; accumulation of a toxic intermediate metabolite, valproic acid; increased serum lamotrigine levels, lamotrigine; increased serum lamotrigine levels, valproic acid