1538
PATIENTS : Two patients , ages 40 and 51 years , undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral , sequential visual loss with disc - related field defects and segmental optic disc edema .
 sudden bilateral , sequential visual loss, interferon alfa
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 sudden bilateral , sequential visual loss, interferon alfa