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We present two cases of nitrofurantoin - induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma , thought to represent established fibrosis .
 distortion of the lung parenchyma, nitrofurantoin; fibrosis, nitrofurantoin; pulmonary toxicity, nitrofurantoin; widespread reticular pattern, nitrofurantoin
Please list all entity pairs containing a certain relationship in the given options.Output format is "word1, word2; word3, word4". 
Option: adverse effect 
Text: {0} 
Answer:
 distortion of the lung parenchyma, nitrofurantoin; fibrosis, nitrofurantoin; pulmonary toxicity, nitrofurantoin; widespread reticular pattern, nitrofurantoin