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There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.
 more than 20 observations of the appearance or aggravation of this granulomatosis: Effect; interferon alfa and more recently with the combination of interferon alfa plus ribavirin: Treatment; interferon alfa: Treatment.Drug; interferon alfa: Treatment.Drug; ribavirin: Treatment.Drug; interferon alfa: Combination.Drug; ribavirin: Combination.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 more than 20 observations of the appearance or aggravation of this granulomatosis: Effect; interferon alfa and more recently with the combination of interferon alfa plus ribavirin: Treatment; interferon alfa: Treatment.Drug; interferon alfa: Treatment.Drug; ribavirin: Treatment.Drug; interferon alfa: Combination.Drug; ribavirin: Combination.Drug