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Discontinuation of methicillin therapy and appropriate antibiotic treatment of endocarditis led to clinical improvement, emphasizing the need to promptly discontinue potential nephrotoxic agents when abnormalities in renal function appear.
 abnormalities in renal function: Effect; methicillin: Treatment; methicillin: Treatment.Drug; antibiotic: Treatment.Drug; nephrotoxic agents: Treatment.Drug; endocarditis: Treatment.Disorder
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 abnormalities in renal function: Effect; methicillin: Treatment; methicillin: Treatment.Drug; antibiotic: Treatment.Drug; nephrotoxic agents: Treatment.Drug; endocarditis: Treatment.Disorder