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We report a case of methotrexate toxicity potentially induced by a drug interaction between methotrexate and omeprazole in a 25-year-old man with osteosarcoma.
 a 25-year-old man with osteosarcoma: Subject; 25-year-old: Subject.Age; man: Subject.Gender; osteosarcoma: Subject.Disorder; methotrexate toxicity: Effect; methotrexate and omeprazole: Treatment; methotrexate: Treatment.Drug; omeprazole: Treatment.Drug; methotrexate: Combination.Drug; omeprazole: Combination.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 a 25-year-old man with osteosarcoma: Subject; 25-year-old: Subject.Age; man: Subject.Gender; osteosarcoma: Subject.Disorder; methotrexate toxicity: Effect; methotrexate and omeprazole: Treatment; methotrexate: Treatment.Drug; omeprazole: Treatment.Drug; methotrexate: Combination.Drug; omeprazole: Combination.Drug