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Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.
 Four patients: Subject; Four: Subject.Population; retinal changes: Effect; high-dose tamoxifen for greater than 1 year: Treatment; 1 year: Treatment.Duration; high-dose: Treatment.Dosage; tamoxifen: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 Four patients: Subject; Four: Subject.Population; retinal changes: Effect; high-dose tamoxifen for greater than 1 year: Treatment; 1 year: Treatment.Duration; high-dose: Treatment.Dosage; tamoxifen: Treatment.Drug