479
Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).
 Exacerbations of the heart failure: Effect; antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559): Treatment; actinomycin-D: Treatment.Drug; mithramycin: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 Exacerbations of the heart failure: Effect; antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559): Treatment; actinomycin-D: Treatment.Drug; mithramycin: Treatment.Drug