856
In the present case report, the concomitant administration of clarithromycin and sirolimus determined impressive increase of sirolimus trough blood concentrations from 6.2 up to 54 ng/mL and this increase was associated with an acute impairment of renal function, almost completely reversed upon both drugs discontinuation.
 acute impairment of renal function: Effect; the concomitant administration of clarithromycin and sirolimus: Treatment; clarithromycin: Treatment.Drug; sirolimus: Treatment.Drug; clarithromycin: Combination.Drug; sirolimus: Combination.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 acute impairment of renal function: Effect; the concomitant administration of clarithromycin and sirolimus: Treatment; clarithromycin: Treatment.Drug; sirolimus: Treatment.Drug; clarithromycin: Combination.Drug; sirolimus: Combination.Drug