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We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.
 two patients: Subject; two: Subject.Population; painful erosions of their psoriasis: Effect; methotrexate: Treatment; psoriasis: Treatment.Disorder; methotrexate: Treatment.Drug
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 two patients: Subject; two: Subject.Population; painful erosions of their psoriasis: Effect; methotrexate: Treatment; psoriasis: Treatment.Disorder; methotrexate: Treatment.Drug