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A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.
 10-year-old boy with osteosarcoma and normal renal function: Subject; 10-year-old: Subject.Age; boy: Subject.Gender; impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase: Effect; acute renal failure with life-threatening hyperkalemia 29 hours later: Effect; 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2): Treatment; within 2 hours: Treatment.Time_elapsed; 29 hours later: Treatment.Time_elapsed; infusion: Treatment.Route; methotrexate: Treatment.Drug; high-dose: Treatment.Dosage; 12 g/m2: Treatment.Dosage; 4-hour: Treatment.Duration; osteosarcoma: Treatment.Disorder
Given event type and trigger, please tell me the arguments of all the listed option. Output format is "name1: role1; name2: role2". 
Event type: adverse event 
  Option: Treatment.Freq, Subject.Population, Combination.Drug, Subject.Gender, Treatment.Duration, Subject, Effect, Treatment, Treatment.Disorder, Subject.Disorder, Treatment.Route, Subject.Race, Treatment.Time_elapsed, Treatment.Dosage, Subject.Age, Treatment.Drug 
Text: {0} 
Answer:
 10-year-old boy with osteosarcoma and normal renal function: Subject; 10-year-old: Subject.Age; boy: Subject.Gender; impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase: Effect; acute renal failure with life-threatening hyperkalemia 29 hours later: Effect; 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2): Treatment; within 2 hours: Treatment.Time_elapsed; 29 hours later: Treatment.Time_elapsed; infusion: Treatment.Route; methotrexate: Treatment.Drug; high-dose: Treatment.Dosage; 12 g/m2: Treatment.Dosage; 4-hour: Treatment.Duration; osteosarcoma: Treatment.Disorder