13889
Interestingly, TGF-alpha production by eosinophils was up-regulated by IL-3 and IL-5 but was down-regulated by IL-4 .
 ( cell type: eosinophils, None) , ( protein: IL-5, None) , ( protein: IL-3, None) , ( protein: TGF-alpha, None) , ( protein: IL-4, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: eosinophils, None) , ( protein: IL-5, None) , ( protein: IL-3, None) , ( protein: TGF-alpha, None) , ( protein: IL-4, None) 