1083
The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.
 ( adverse event: demonstrated ,  this 58-year-old female: Subject, 58-year-old: Subject.Age, female: Subject.Gender, leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis: Effect, antithyroid therapy with 20 mg methimazole daily: Treatment, 20 days after: Treatment.Time_elapsed, methimazole: Treatment.Drug, 20 mg: Treatment.Dosage, daily: Treatment.Freq) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: demonstrated ,  this 58-year-old female: Subject, 58-year-old: Subject.Age, female: Subject.Gender, leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis: Effect, antithyroid therapy with 20 mg methimazole daily: Treatment, 20 days after: Treatment.Time_elapsed, methimazole: Treatment.Drug, 20 mg: Treatment.Dosage, daily: Treatment.Freq) 