2519
IL-4 down-regulated mRNA accumulation of the proinflammatory cytokines IL-1 beta , IL-8 , and TNF-alpha in monocytes stimulated with IL-2 , IL-3 , and GM-CSF .
 ( protein: IL-1 beta, None) , ( protein: GM-CSF, None) , ( protein: TNF-alpha, None) , ( protein: IL-3, None) , ( protein: proinflammatory cytokines, None) , ( cell type: monocytes, None) , ( protein: IL-2, None) , ( protein: IL-8, None) , ( protein: IL-4, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-1 beta, None) , ( protein: GM-CSF, None) , ( protein: TNF-alpha, None) , ( protein: IL-3, None) , ( protein: proinflammatory cytokines, None) , ( cell type: monocytes, None) , ( protein: IL-2, None) , ( protein: IL-8, None) , ( protein: IL-4, None) 