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We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.
 ( adverse event: after ,  2 patients with cutaneous lupus erythematosus: Subject, 2: Subject.Population, severe dapsone reaction: Effect, with a fatal outcome in one: Effect, low dose therapy: Treatment, cutaneous lupus erythematosus: Treatment.Disorder, low dose: Treatment.Dosage, dapsone: Treatment.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: after ,  2 patients with cutaneous lupus erythematosus: Subject, 2: Subject.Population, severe dapsone reaction: Effect, with a fatal outcome in one: Effect, low dose therapy: Treatment, cutaneous lupus erythematosus: Treatment.Disorder, low dose: Treatment.Dosage, dapsone: Treatment.Drug) 