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We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.
 ( potential therapeutic event: treated ,  in five patients with thalassemia intermedia: Subject, five: Subject.Population, increases in total Hb and decreased transfusion needs: Effect, HU alone or in combination with SPB: Treatment, HU: Treatment.Drug, SPB: Treatment.Drug, thalassemia intermedia: Treatment.Disorder, HU: Combination.Drug, SPB: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( potential therapeutic event: treated ,  in five patients with thalassemia intermedia: Subject, five: Subject.Population, increases in total Hb and decreased transfusion needs: Effect, HU alone or in combination with SPB: Treatment, HU: Treatment.Drug, SPB: Treatment.Drug, thalassemia intermedia: Treatment.Disorder, HU: Combination.Drug, SPB: Combination.Drug) 