1674
It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.
 ( adverse event: leading ,  increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite: Effect, valproic acid may interfere with glucuronidation of lamotrigine: Treatment, valproic acid: Treatment.Drug, lamotrigine: Treatment.Drug, valproic acid: Combination.Drug, lamotrigine: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: leading ,  increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite: Effect, valproic acid may interfere with glucuronidation of lamotrigine: Treatment, valproic acid: Treatment.Drug, lamotrigine: Treatment.Drug, valproic acid: Combination.Drug, lamotrigine: Combination.Drug) 