10407
Additional major protein-DNA interactions do not occur within the promoter region after T lymphocyte activation , indicating a requirement for additional protein-protein interactions and/or post-translational modifications of pre-bound transcription factors to account for the observed increase in IMPDH type II gene expression .
 ( protein: pre-bound transcription factors, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: pre-bound transcription factors, None) 