5148
Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F , which subsequently promotes the expression of S phase regulated genes , such as thymidine kinase .
 ( protein: retinoblastoma protein, None) , ( DNA: S phase regulated genes, None) , ( protein: thymidine kinase, None) , ( protein: E2F, None) , ( protein: transcription factor, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: retinoblastoma protein, None) , ( DNA: S phase regulated genes, None) , ( protein: thymidine kinase, None) , ( protein: E2F, None) , ( protein: transcription factor, None) 