3445
A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production .
 ( protein: transcription factor, None) , ( protein: AP-1, None) , ( protein: p21(ras), None) , ( DNA: IL-2 gene, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: transcription factor, None) , ( protein: AP-1, None) , ( protein: p21(ras), None) , ( DNA: IL-2 gene, None) 