2894
A 53-year-old man developed lower leg edema 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day.
 ( adverse event: after ,  A 53-year-old man: Subject, 53-year-old: Subject.Age, man: Subject.Gender, lower leg edema: Effect, 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day: Treatment, 4 weeks: Treatment.Time_elapsed, rosiglitazone: Treatment.Drug, 4 mg: Treatment.Dosage, twice/day: Treatment.Freq) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: after ,  A 53-year-old man: Subject, 53-year-old: Subject.Age, man: Subject.Gender, lower leg edema: Effect, 4 weeks after rosiglitazone was increased from 4 mg once/day to 4 mg twice/day: Treatment, 4 weeks: Treatment.Time_elapsed, rosiglitazone: Treatment.Drug, 4 mg: Treatment.Dosage, twice/day: Treatment.Freq) 