12354
These studies revealed that Calphostin C inhibited the nuclear translocation of the transcription factor activator protein-1 ( AP-1 ) which is considered necessary for FN induction of IL-1beta gene transcription , and prevented the transcription of the IL-1beta gene .
 ( DNA: IL-1beta gene, None) , ( protein: IL-1beta, None) , ( protein: AP-1, None) , ( protein: transcription factor activator protein-1, None) , ( protein: transcription factor, None) , ( protein: IL-1beta, None) , ( protein: FN, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( DNA: IL-1beta gene, None) , ( protein: IL-1beta, None) , ( protein: AP-1, None) , ( protein: transcription factor activator protein-1, None) , ( protein: transcription factor, None) , ( protein: IL-1beta, None) , ( protein: FN, None) 