14203
Here we report that binding of human IL-2 to its binding site leads to transcriptional activation of the macrophage CSF ( M-CSF ) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity-stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody .
 ( protein: human IL-2, None) , ( protein: M-CSF, None) , ( protein: IL-2, None) , ( protein: anti-M-CSF antibody, None) , ( RNA: M-CSF mRNA, None) , ( cell type: Mo, None) , ( DNA: macrophage CSF ( M-CSF ) gene, None) , ( protein: M-CSF protein, None) , ( protein: M-CSF, None) , ( cell line: monocyte-type colonies, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: human IL-2, None) , ( protein: M-CSF, None) , ( protein: IL-2, None) , ( protein: anti-M-CSF antibody, None) , ( RNA: M-CSF mRNA, None) , ( cell type: Mo, None) , ( DNA: macrophage CSF ( M-CSF ) gene, None) , ( protein: M-CSF protein, None) , ( protein: M-CSF, None) , ( cell line: monocyte-type colonies, None) 