9415
Transfection studies of LTR reporter constructs indicated that mutation of the DSE sites abrogated the LTR -mediated synergy induced by Ctx and TNFalpha , whereas the synergy induced by Ctx and IL-1beta was unaffected, suggesting TNFalpha and IL-1beta cooperate differently with the cAMP /PKA activation pathway to induce HIV-1 expression in U1 cells .
 ( protein: Ctx, None) , ( protein: IL-1beta, None) , ( cell line: U1 cells, None) , ( protein: IL-1beta, None) , ( protein: TNFalpha, None) , ( protein: /PKA, None) , ( protein: Ctx, None) , ( DNA: DSE, None) , ( DNA: LTR, None) , ( DNA: DSE sites, None) , ( protein: TNFalpha, None) , ( DNA: LTR reporter constructs, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: Ctx, None) , ( protein: IL-1beta, None) , ( cell line: U1 cells, None) , ( protein: IL-1beta, None) , ( protein: TNFalpha, None) , ( protein: /PKA, None) , ( protein: Ctx, None) , ( DNA: DSE, None) , ( DNA: LTR, None) , ( DNA: DSE sites, None) , ( protein: TNFalpha, None) , ( DNA: LTR reporter constructs, None) 