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As several inflammatory cytokines and oxidative stresses are involved in the pathogenesis of HIV-1 infection , we investigated the inhibitory effects of cepharanthine on tumor necrosis factor alpha ( TNF-alpha )- and phorbol 12-myristate 13-acetate ( PMA )- induced HIV-1 replication in chronically infected cell lines .
 ( protein: inflammatory cytokines, None) , ( protein: TNF-alpha, None) , ( protein: cytokines, None) , ( cell line: chronically infected cell lines, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: inflammatory cytokines, None) , ( protein: TNF-alpha, None) , ( protein: cytokines, None) , ( cell line: chronically infected cell lines, None) 