10807
Previous reports have suggested the CD28 stimulation contributes to the activation of the IL-2 promoter by up-regulating the activity of several transcription factors , including AP-1 and nuclear factor-kappaB ( NF-kappaB )/ Rel family members as well as an uncharacterized transcription factor called CD28 response complex.
 ( protein: IL-2, None) , ( protein: CD28, None) , ( protein: nuclear factor-kappaB ( NF-kappaB )/ Rel family members, None) , ( protein: transcription factors, None) , ( protein: CD28, None) , ( protein: Rel, None) , ( protein: uncharacterized transcription factor, None) , ( DNA: IL-2 promoter, None) , ( protein: nuclear factor-kappaB, None) , ( protein: NF-kappaB, None) , ( protein: AP-1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-2, None) , ( protein: CD28, None) , ( protein: nuclear factor-kappaB ( NF-kappaB )/ Rel family members, None) , ( protein: transcription factors, None) , ( protein: CD28, None) , ( protein: Rel, None) , ( protein: uncharacterized transcription factor, None) , ( DNA: IL-2 promoter, None) , ( protein: nuclear factor-kappaB, None) , ( protein: NF-kappaB, None) , ( protein: AP-1, None) 