7447
Whereas IL-4 appears to repress functional IL-12 signaling through inhibition of IL-12R beta 2 expression , IFN-gamma in the mouse, and IFN-alpha in the human appear to induce IL-12R beta 2 expression and promote IL-12 responsiveness .
 ( protein: IL-12, None) , ( protein: IL-12R beta 2, None) , ( protein: IL-12R beta 2, None) , ( protein: IL-4, None) , ( protein: IL-12, None) , ( protein: IFN-alpha, None) , ( protein: IFN-gamma, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-12, None) , ( protein: IL-12R beta 2, None) , ( protein: IL-12R beta 2, None) , ( protein: IL-4, None) , ( protein: IL-12, None) , ( protein: IFN-alpha, None) , ( protein: IFN-gamma, None) 