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The clinical use of itraconazole in patients receiving multiple doses of oxycodone for pain relief may increase the risk of opioid-associated adverse effects.
 ( adverse event: increase ,  patients: Subject, opioid-associated adverse effects: Effect, itraconazole: Treatment, receiving multiple doses of oxycodone: Treatment, pain relief: Treatment.Disorder, oxycodone: Treatment.Drug, itraconazole: Treatment.Drug, multiple doses: Treatment.Dosage, itraconazole: Combination.Drug, oxycodone: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: increase ,  patients: Subject, opioid-associated adverse effects: Effect, itraconazole: Treatment, receiving multiple doses of oxycodone: Treatment, pain relief: Treatment.Disorder, oxycodone: Treatment.Drug, itraconazole: Treatment.Drug, multiple doses: Treatment.Dosage, itraconazole: Combination.Drug, oxycodone: Combination.Drug) 