5369
In contrast, repeated injections of SEA cause CD4+ T-cell deletion and anergy in the remaining CD4+ T cells , characterized by reduced expression of IL-2 at mRNA and protein levels .
 ( protein: CD4+ T-cell deletion, None) , ( cell type: T cells, None) , ( cell type: CD4+ T-cell, None) , ( protein: SEA, None) , ( protein: IL-2, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CD4+ T-cell deletion, None) , ( cell type: T cells, None) , ( cell type: CD4+ T-cell, None) , ( protein: SEA, None) , ( protein: IL-2, None) 