7282
We conclude that (1) HTLV-I infection per se does not result in a constitutive phosphorylation of the Jak3 , STAT3 , and STAT5 proteins; (2) malignant transformation in at least some cases of ATLL does not require the constitutive, but may require IL-2 -induced, activation of the IL-2R Jak/STAT pathway ; and (3) there are major differences in T-cell immortalization mechanism (s) which appear to involve SHP-1 and target molecules for rapamycin and RAD .
 ( protein: IL-2R, None) , ( protein: IL-2, None) , ( protein: SHP-1, None) , ( protein: Jak/STAT, None) , ( protein: STAT5, None) , ( protein: STAT3, None) , ( protein: Jak3, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-2R, None) , ( protein: IL-2, None) , ( protein: SHP-1, None) , ( protein: Jak/STAT, None) , ( protein: STAT5, None) , ( protein: STAT3, None) , ( protein: Jak3, None) 