6486
We showed that IL-12 had a direct effect on IRF-1 , an effect not mediated indirectly by the induction of IFN-gamma production .
 ( protein: IRF-1, None) , ( protein: IFN-gamma, None) , ( protein: IL-12, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IRF-1, None) , ( protein: IFN-gamma, None) , ( protein: IL-12, None) 