4265
Treatment of B lymphocytes with the cytokine IL-4 ( IL-4 ), in the absence of prior activation, induces a weak up-regulation of VDR expression but fails to generate vitamin D-responsive element ( VDRE )-reactive nuclear protein complexes or to initiate the genomic transcription of 25-hydroxyvitamin D3 24-hydroxylase .
 ( protein: IL-4, None) , ( protein: cytokine, None) , ( protein: 25-hydroxyvitamin D3 24-hydroxylase, None) , ( protein: VDR, None) , ( DNA: vitamin D-responsive element, None) , ( cell type: B lymphocytes, None) , ( protein: IL-4, None) , ( protein: vitamin D-responsive element ( VDRE )-reactive nuclear protein complexes, None) , ( DNA: VDRE, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-4, None) , ( protein: cytokine, None) , ( protein: 25-hydroxyvitamin D3 24-hydroxylase, None) , ( protein: VDR, None) , ( DNA: vitamin D-responsive element, None) , ( cell type: B lymphocytes, None) , ( protein: IL-4, None) , ( protein: vitamin D-responsive element ( VDRE )-reactive nuclear protein complexes, None) , ( DNA: VDRE, None) 