4559
Thus, these results show that age-related impairments in the activation of AP-1 and NF-AT are closely associated with decreased expression of IL-2 and further suggest that aberrancies in the signaling pathways important for the induction of transcriptionally active c-Fos/c-Jun AP-1 may contribute to the impaired activation of NF-AT .
 ( protein: c-Fos/c-Jun, None) , ( protein: NF-AT, None) , ( protein: AP-1, None) , ( protein: NF-AT, None) , ( protein: IL-2, None) , ( protein: AP-1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: c-Fos/c-Jun, None) , ( protein: NF-AT, None) , ( protein: AP-1, None) , ( protein: NF-AT, None) , ( protein: IL-2, None) , ( protein: AP-1, None) 