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Concurrent use of vismodegib and warfarin was deemed the probable cause of acute INR elevation in this case, suggesting the need for close monitoring of INR values in patients receiving this combination of drugs.
 ( adverse event: cause ,  acute INR elevation: Effect, vismodegib and warfarin: Treatment, vismodegib: Treatment.Drug, warfarin: Treatment.Drug, vismodegib: Combination.Drug, warfarin: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: cause ,  acute INR elevation: Effect, vismodegib and warfarin: Treatment, vismodegib: Treatment.Drug, warfarin: Treatment.Drug, vismodegib: Combination.Drug, warfarin: Combination.Drug) 