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Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.
 ( adverse event: increase ,  a case of conjunctiva-cornea intraepithelial neoplasia: Subject, Tumor-volume increase: Effect, primary treatment with topical interferon alpha 2-beta: Treatment, interferon alpha 2-beta: Treatment.Drug, topical: Treatment.Route, beginning: Treatment.Time_elapsed, conjunctiva-cornea intraepithelial neoplasia: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: increase ,  a case of conjunctiva-cornea intraepithelial neoplasia: Subject, Tumor-volume increase: Effect, primary treatment with topical interferon alpha 2-beta: Treatment, interferon alpha 2-beta: Treatment.Drug, topical: Treatment.Route, beginning: Treatment.Time_elapsed, conjunctiva-cornea intraepithelial neoplasia: Treatment.Disorder) 