4159
These data suggest that in activated normal T cells , CD28 -derived signals can stimulate proliferation at least in part via NF-kappaB and AP-1 generation , and that this response uses both acidic sphingomyelinase and phosphatidylinositol 3-kinase -linked pathways .
 ( protein: CD28, None) , ( protein: phosphatidylinositol 3-kinase, None) , ( protein: acidic sphingomyelinase, None) , ( cell type: normal T cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CD28, None) , ( protein: phosphatidylinositol 3-kinase, None) , ( protein: acidic sphingomyelinase, None) , ( cell type: normal T cells, None) 