6491
Therefore, IRF-1 may be an important contributor to IL-12 signaling , and we speculate that the defective IL-12 responses seen in IRF -1-/- mice might be attributable, in part, to the absence of this transcription factor .
 ( protein: IRF, None) , ( protein: transcription factor, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( protein: IRF-1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IRF, None) , ( protein: transcription factor, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( protein: IRF-1, None) 