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CONCLUSIONS: The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy.
 ( adverse event: development ,  The 3 cases: Subject, women with epilepsy: Subject, 3: Subject.Population, women: Subject.Gender, reproductive endocrine disorders: Effect, after the initiation of valproate therapy: Treatment, valproate: Treatment.Drug, epilepsy: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: development ,  The 3 cases: Subject, women with epilepsy: Subject, 3: Subject.Population, women: Subject.Gender, reproductive endocrine disorders: Effect, after the initiation of valproate therapy: Treatment, valproate: Treatment.Drug, epilepsy: Treatment.Disorder) 