1017
Three cycles of chemotherapy had been administered without complications when, at the beginning of the fourth cycle, the patient developed clinical and laboratory abnormalities consistent with the development of the hemolytic-uremic syndrome.
 ( adverse event: developed ,  the patient: Subject, hemolytic-uremic syndrome.: Effect, chemotherapy: Treatment, at the beginning of the fourth cycle: Treatment, chemotherapy: Treatment.Drug, fourth cycle: Treatment.Duration) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: developed ,  the patient: Subject, hemolytic-uremic syndrome.: Effect, chemotherapy: Treatment, at the beginning of the fourth cycle: Treatment, chemotherapy: Treatment.Drug, fourth cycle: Treatment.Duration) 