4120
Enzymatic assay of alpha-galactosidase in blood leucocytes , skin fibroblasts , Epstein-Barr virus transformed lymphoid cell lines , and hair follicles of the twins and their parents confirmed the heterozygous status of the twins and indicated that Fabry disease had occurred as a result of a de novo mutation.
 ( cell type: skin fibroblasts, None) , ( cell line: Epstein-Barr virus transformed lymphoid cell lines, None) , ( protein: alpha-galactosidase, None) , ( cell type: blood leucocytes, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: skin fibroblasts, None) , ( cell line: Epstein-Barr virus transformed lymphoid cell lines, None) , ( protein: alpha-galactosidase, None) , ( cell type: blood leucocytes, None) 