11697
CONCLUSIONS: Our results establish that PI 3-kinase can both positively and negatively regulate T-cell function , and uncover a previously unrecognized function for PI 3-kinase in T cells as a selective negative regulator of TCR -signalling events and therefore as a determinant of T-cell homeostasis .
 ( protein: TCR, None) , ( cell type: T cells, None) , ( protein: PI 3-kinase, None) , ( protein: PI 3-kinase, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: TCR, None) , ( cell type: T cells, None) , ( protein: PI 3-kinase, None) , ( protein: PI 3-kinase, None) 