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To delineate the effects of these motifs on the replicative capacity of HIV and to explore the possibility of extending the virus host range, known heterologous enhancer/promoters were inserted into the HIV-1 LTR in place of the NF-kappa B and Sp1 binding sites .
 ( DNA: HIV-1 LTR, None) , ( DNA: Sp1 binding sites, None) , ( DNA: heterologous enhancer/promoters, None) , ( protein: NF-kappa B, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( DNA: HIV-1 LTR, None) , ( DNA: Sp1 binding sites, None) , ( DNA: heterologous enhancer/promoters, None) , ( protein: NF-kappa B, None) 