2330
Elements necessary for the steroid hormone 1 alpha,25-dihydroxyvitamin D3 ( 1 alpha,25-(OH)2D3 ) to induce a biological response include the presence of specific intracellular receptors ( vitamin D3 receptors ( VDR )) and modulation of gene expression via hormone-activated receptor binding to regulatory regions of target genes .
 ( protein: VDR, None) , ( protein: vitamin D3 receptors, None) , ( protein: regulatory regions, None) , ( protein: intracellular receptors, None) , ( DNA: target genes, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: VDR, None) , ( protein: vitamin D3 receptors, None) , ( protein: regulatory regions, None) , ( protein: intracellular receptors, None) , ( DNA: target genes, None) 