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The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells , and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B ( NF-kappa B ).
 ( protein: nuclear factor kappa B, None) , ( cell line: tolerant cells, None) , ( protein: CD14, None) , ( protein: transcription factor, None) , ( protein: NF-kappa B, None) , ( cell line: tolerant cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: nuclear factor kappa B, None) , ( cell line: tolerant cells, None) , ( protein: CD14, None) , ( protein: transcription factor, None) , ( protein: NF-kappa B, None) , ( cell line: tolerant cells, None) 