2720
We report here that PML is expressed at low levels or not expressed in normal circulating human monocytes , lymphocytes , and polymorphonucleate cells , but is markedly induced by interferon ; that PML and PML/RAR alpha expression is augmented by interferon in the NB4 APL cell line , which carries the t(15; 17) , and in APL blasts from patients ; that interferon inhibits growth and survival of NB4 APL cells in cooperation with RA ; that interferons alone have minimal maturation effect on NB4 cells ; and, finally, that interferon gamma , but not alpha or beta , induces maturation and growth suppression of NB4 cells with de novo retinoid resistance , and partially restores RA response .
 ( protein: PML, None) , ( cell line: NB4 APL cell line, None) , ( protein: PML/RAR alpha, None) , ( cell type: lymphocytes, None) , ( cell line: NB4 cells, None) , ( protein: interferon, None) , ( cell type: APL cells, None) , ( DNA: t(15; 17), None) , ( protein: interferon, None) , ( cell type: monocytes, None) , ( cell type: human monocytes, None) , ( cell line: NB4 cells, None) , ( protein: interferon, None) , ( protein: PML, None) , ( cell type: APL blasts, None) , ( cell type: polymorphonucleate cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: PML, None) , ( cell line: NB4 APL cell line, None) , ( protein: PML/RAR alpha, None) , ( cell type: lymphocytes, None) , ( cell line: NB4 cells, None) , ( protein: interferon, None) , ( cell type: APL cells, None) , ( DNA: t(15; 17), None) , ( protein: interferon, None) , ( cell type: monocytes, None) , ( cell type: human monocytes, None) , ( cell line: NB4 cells, None) , ( protein: interferon, None) , ( protein: PML, None) , ( cell type: APL blasts, None) , ( cell type: polymorphonucleate cells, None) 