13630
The pathological alteration of this cytokine pathway leading to NF-kappaB activation by Tax may play a central role in HTLV-1 -mediated transformation of human T cells , clinically manifested as the adult T-cell leukemia
 ( protein: Tax, None) , ( cell type: human T cells, None) , ( protein: NF-kappaB, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: Tax, None) , ( cell type: human T cells, None) , ( protein: NF-kappaB, None) 