6558
When a therapy proves effective, do clinicians truly know how it works? Even with a therapy as specific as anti-TNF antibody , it is not clear if the benefit is attributable to simple binding and clearance of TNF-alpha or to binding on the cell surface and subsequent deletion of the activated macrophage .
 ( protein: anti-TNF antibody, None) , ( cell type: activated macrophage, None) , ( protein: TNF-alpha, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: anti-TNF antibody, None) , ( cell type: activated macrophage, None) , ( protein: TNF-alpha, None) 