2599
The gp160 -mediated activation of NF-kappa B in CD4 positive T cells may be involved in biological effects, e.g., enhanced HIV replication , hypergammaglobulinemia , increased cytokine secretion , hypercellularity in bone marrow and apoptosis .
 ( cell type: CD4 positive T cells, None) , ( protein: CD4, None) , ( protein: NF-kappa B, None) , ( protein: cytokine, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: CD4 positive T cells, None) , ( protein: CD4, None) , ( protein: NF-kappa B, None) , ( protein: cytokine, None) 