3752
These results suggest that phosphorylated pRB is constitutively expressed in MM cells and that IL-6 further shifts pRB from its dephosphorylated to its phosphorylated form, thereby promoting MM cell growth via two mechanisms; by decreasing the amount of E2F bound by dephosphorylated pRB due to reduced dephosphorylated pRB , thereby releasing growth arrest; and by upregulating IL-6 secretion by MM cells and related IL-6 -mediated autocrine tumor cell growth .
 ( protein: pRB, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: phosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: dephosphorylated pRB, None) , ( protein: dephosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: pRB, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: pRB, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: phosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: dephosphorylated pRB, None) , ( protein: dephosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: pRB, None) 