3027
In exerting their antiproliferative effects, GCS diffuse into target cells where they bind their cytoplasmic receptor , which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements ( GRE ), which are located in the promoter region of cytokine genes or, alternatively, through antagonism of the action of transcription factors required for optimal transcriptional activation .
 ( cell type: target cells, None) , ( DNA: glucocorticoid response elements, None) , ( DNA: cytokine genes, None) , ( protein: cytokine, None) , ( DNA: cytokine genes, None) , ( protein: transcription factors, None) , ( protein: cytokine, None) , ( protein: cytoplasmic receptor, None) , ( DNA: GRE, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: target cells, None) , ( DNA: glucocorticoid response elements, None) , ( DNA: cytokine genes, None) , ( protein: cytokine, None) , ( DNA: cytokine genes, None) , ( protein: transcription factors, None) , ( protein: cytokine, None) , ( protein: cytoplasmic receptor, None) , ( DNA: GRE, None) 