7183
CTLA-4 ligation inhibited CD3/ CD28 -induced IL-2 mRNA accumulation by inhibiting IL-2 transcription , which appears to be mediated in part through decreasing NF-AT accumulation in the nuclei .
 ( protein: IL-2, None) , ( protein: CD28, None) , ( protein: NF-AT, None) , ( RNA: IL-2 mRNA, None) , ( protein: IL-2, None) , ( protein: CTLA-4, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-2, None) , ( protein: CD28, None) , ( protein: NF-AT, None) , ( RNA: IL-2 mRNA, None) , ( protein: IL-2, None) , ( protein: CTLA-4, None) 