11696
These effects of PI 3-kinase were not mediated by previously identified PI 3-kinase effectors , such as protein kinase B , a positive regulator of PI 3-kinase , or the GTPase Rac , and are therefore likely to involve a novel, as yet unknown, effector molecule .
 ( protein: positive regulator, None) , ( protein: effector molecule, None) , ( protein: PI 3-kinase, None) , ( protein: GTPase, None) , ( protein: PI 3-kinase effectors, None) , ( protein: GTPase Rac, None) , ( protein: protein kinase B, None) , ( protein: PI 3-kinase, None) , ( protein: Rac, None) , ( protein: PI 3-kinase, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: positive regulator, None) , ( protein: effector molecule, None) , ( protein: PI 3-kinase, None) , ( protein: GTPase, None) , ( protein: PI 3-kinase effectors, None) , ( protein: GTPase Rac, None) , ( protein: protein kinase B, None) , ( protein: PI 3-kinase, None) , ( protein: Rac, None) , ( protein: PI 3-kinase, None) 