12650
These observations suggest that protein glycation in pancreatic beta cells , which occurs in vivo under chronic hyperglycemia , suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity .
 ( cell type: pancreatic beta cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: pancreatic beta cells, None) 