5153
Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase , paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter .
 ( protein: thymidine kinase, None) , ( protein: thymidine kinase, None) , ( protein: retinoblastoma protein, None) , ( protein: E2F, None) , ( cell line: leukemia cell lines, None) , ( protein: p16, None) , ( DNA: thymidine kinase promoter, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: thymidine kinase, None) , ( protein: thymidine kinase, None) , ( protein: retinoblastoma protein, None) , ( protein: E2F, None) , ( cell line: leukemia cell lines, None) , ( protein: p16, None) , ( DNA: thymidine kinase promoter, None) 