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A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr.
 ( adverse event: developed ,  A 58-yr-old male patient with essential thrombocythaemia (ET): Subject, 58-yr-old: Subject.Age, male: Subject.Gender, chronic myeloid leukaemia (CML): Effect, continuous uneventful treatment with hydroxyurea for 18 yr: Treatment, essential thrombocythaemia (ET): Treatment.Disorder, hydroxyurea: Treatment.Drug, 18 yr: Treatment.Duration) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: developed ,  A 58-yr-old male patient with essential thrombocythaemia (ET): Subject, 58-yr-old: Subject.Age, male: Subject.Gender, chronic myeloid leukaemia (CML): Effect, continuous uneventful treatment with hydroxyurea for 18 yr: Treatment, essential thrombocythaemia (ET): Treatment.Disorder, hydroxyurea: Treatment.Drug, 18 yr: Treatment.Duration) 