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A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion.
 ( adverse event: developed ,  17-year-old boy with acute lymphoblastic leukemia: Subject, 17-year-old: Subject.Age, boy: Subject.Gender, acute renal failure: Effect, intravenous high-dose methotrexate (5 g/m2) infusion: Treatment, intravenous: Treatment.Route, methotrexate: Treatment.Drug, 5 g/m2: Treatment.Dosage, within 48 h: Treatment.Time_elapsed, acute lymphoblastic leukemia: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: developed ,  17-year-old boy with acute lymphoblastic leukemia: Subject, 17-year-old: Subject.Age, boy: Subject.Gender, acute renal failure: Effect, intravenous high-dose methotrexate (5 g/m2) infusion: Treatment, intravenous: Treatment.Route, methotrexate: Treatment.Drug, 5 g/m2: Treatment.Dosage, within 48 h: Treatment.Time_elapsed, acute lymphoblastic leukemia: Treatment.Disorder) 