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IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase .
 ( protein: 5-lipoxygenase, None) , ( protein: NF-kappa B, None) , ( DNA: IL-2 gene, None) , ( protein: CD28, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: 5-lipoxygenase, None) , ( protein: NF-kappa B, None) , ( DNA: IL-2 gene, None) , ( protein: CD28, None) 