1875
The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.
 ( adverse event: associated ,  The patient: Subject, a painful hand ulcer: Effect, new skin cancers: Effect, hydroxyurea: Treatment, skin lesions: Treatment.Disorder, 10-month: Treatment.Duration, hydroxyurea: Treatment.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: associated ,  The patient: Subject, a painful hand ulcer: Effect, new skin cancers: Effect, hydroxyurea: Treatment, skin lesions: Treatment.Disorder, 10-month: Treatment.Duration, hydroxyurea: Treatment.Drug) 