11690
Phosphoinositide 3-kinase ( PI 3-kinase ) is activated by a diverse set of receptors that determine T-cell function , including the T-cell antigen receptor ( TCR ), the costimulatory receptor CD28 , and negative regulators of T-cell activation such as CTLA-4 .
 ( protein: CTLA-4, None) , ( protein: TCR, None) , ( protein: negative regulators, None) , ( protein: Phosphoinositide 3-kinase, None) , ( protein: T-cell antigen receptor, None) , ( protein: PI 3-kinase, None) , ( protein: costimulatory receptor CD28, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CTLA-4, None) , ( protein: TCR, None) , ( protein: negative regulators, None) , ( protein: Phosphoinositide 3-kinase, None) , ( protein: T-cell antigen receptor, None) , ( protein: PI 3-kinase, None) , ( protein: costimulatory receptor CD28, None) 