13365
Examination of IkappaB alpha regulation revealed that TNF-alpha -mediated degradation of IkappaB alpha in both memory and naive T cells from the elderly was severely impaired, thus contributing to the lowered induction of the observed NFkappaB .
 ( protein: IkappaB alpha, None) , ( protein: IkappaB alpha, None) , ( protein: NFkappaB, None) , ( protein: TNF-alpha, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IkappaB alpha, None) , ( protein: IkappaB alpha, None) , ( protein: NFkappaB, None) , ( protein: TNF-alpha, None) 