2
In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates ( ROIs ) which are required for CD28 -mediated activation of the NF-kappa B / CD28 -responsive complex and IL-2 expression .
 ( protein: CD28, None) , ( protein: CD28, None) , ( protein: CD28, None) , ( cell type: primary T lymphocytes, None) , ( protein: NF-kappa B, None) , ( protein: CD28 -responsive complex, None) , ( protein: IL-2, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CD28, None) , ( protein: CD28, None) , ( protein: CD28, None) , ( cell type: primary T lymphocytes, None) , ( protein: NF-kappa B, None) , ( protein: CD28 -responsive complex, None) , ( protein: IL-2, None) 