2517
IL-4 , a product of the T-helper 0 ( Th0 ) and 2 ( Th2 ) subset , was originally described as a B-cell stimulatory factor and has subsequently been found to suppress IL-1 alpha , IL-1 beta , IL-6 , IL-8 , and TNF-alpha gene expression in monocytes stimulated with LPS , and to upregulate IL-1 receptor antagonist (IL1-RA) gene expression .
 ( protein: IL-4, None) , ( cell type: monocytes, None) , ( protein: B-cell stimulatory factor, None) , ( cell type: Th2, None) , ( cell type: Th0, None) , ( DNA: IL-1 receptor antagonist (IL1-RA) gene, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-4, None) , ( cell type: monocytes, None) , ( protein: B-cell stimulatory factor, None) , ( cell type: Th2, None) , ( cell type: Th0, None) , ( DNA: IL-1 receptor antagonist (IL1-RA) gene, None) 