2479
Furthermore, the PA -and the anti-CD3 -induced increases in AP-1 enhancer activity were blocked by the presence of PKC inhibitors or by PKC down-regulation .
 ( protein: PKC, None) , ( DNA: AP-1 enhancer, None) , ( protein: anti-CD3, None) , ( protein: PKC, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: PKC, None) , ( DNA: AP-1 enhancer, None) , ( protein: anti-CD3, None) , ( protein: PKC, None) 