12511
Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase ( MAPK ) or the calcineurin /NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways.
 ( protein: /NFAT, None) , ( protein: IL-2, None) , ( protein: Tpl-2, None) , ( protein: calcineurin, None) , ( protein: MAPK, None) , ( protein: mutant signaling molecules, None) , ( protein: signaling molecules, None) , ( DNA: IL-2 promoter, None) , ( protein: mitogen-activated protein kinase, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: /NFAT, None) , ( protein: IL-2, None) , ( protein: Tpl-2, None) , ( protein: calcineurin, None) , ( protein: MAPK, None) , ( protein: mutant signaling molecules, None) , ( protein: signaling molecules, None) , ( DNA: IL-2 promoter, None) , ( protein: mitogen-activated protein kinase, None) 