5231
Thus, changes in the Sp1 binding sites had the most dramatic effects on SIVmac replication in primary macrophage cultures .
 ( cell line: primary macrophage cultures, None) , ( DNA: Sp1 binding sites, None) , ( protein: Sp1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell line: primary macrophage cultures, None) , ( DNA: Sp1 binding sites, None) , ( protein: Sp1, None) 