11499
Functional studies showed a 2.5-fold increase in promoter activity when this 19-bp binding site was deleted in the reporter constructs IL-1beta /CAT and IL-1beta /SV40 promoter /CAT .
 ( DNA: reporter constructs, None) , ( DNA: /SV40 promoter, None) , ( DNA: 19-bp binding site, None) , ( protein: /CAT, None) , ( protein: IL-1beta, None) , ( protein: IL-1beta, None) , ( protein: /CAT, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( DNA: reporter constructs, None) , ( DNA: /SV40 promoter, None) , ( DNA: 19-bp binding site, None) , ( protein: /CAT, None) , ( protein: IL-1beta, None) , ( protein: IL-1beta, None) , ( protein: /CAT, None) 