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We conclude that the presence of this metabolic defect combined with topical 5-FU (a drug demonstrating a narrow therapeutic index) results in the unusual presentation of life-threatening toxicity after treatment with a topical drug.
 ( adverse event: results in ,  this metabolic defect: Subject, metabolic defect: Subject.Disorder, unusual presentation of life-threatening toxicity: Effect, topical 5-FU (a drug demonstrating a narrow therapeutic index): Treatment, 5-FU: Treatment.Drug, topical: Treatment.Route) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: results in ,  this metabolic defect: Subject, metabolic defect: Subject.Disorder, unusual presentation of life-threatening toxicity: Effect, topical 5-FU (a drug demonstrating a narrow therapeutic index): Treatment, 5-FU: Treatment.Drug, topical: Treatment.Route) 