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In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.
 ( adverse event: following ,  a 46-year-old female patient: Subject, 46-year-old: Subject.Age, female: Subject.Gender, subcutaneous changes: Effect, presented as localized panniculitis in the area around the injection sites: Effect, repeated glatiramer acetate injection: Treatment, glatiramer acetate: Treatment.Drug, injection: Treatment.Route) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: following ,  a 46-year-old female patient: Subject, 46-year-old: Subject.Age, female: Subject.Gender, subcutaneous changes: Effect, presented as localized panniculitis in the area around the injection sites: Effect, repeated glatiramer acetate injection: Treatment, glatiramer acetate: Treatment.Drug, injection: Treatment.Route) 