7491
Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein (MAP) kinases Erk 1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells .
 ( protein: mitogen-activated protein (MAP) kinases, None) , ( protein: HePTP, None) , ( protein: HePTP, None) , ( cell type: intact T cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: mitogen-activated protein (MAP) kinases, None) , ( protein: HePTP, None) , ( protein: HePTP, None) , ( cell type: intact T cells, None) 