7301
In T lymphocytes , the hematopoietic cytokine interleukin-2 ( IL-2 ) uses phosphatidylinositol 3-kinase ( PI 3-kinase )-induced signaling pathways to regulate E2F transcriptional activity , a critical cell cycle checkpoint .
 ( protein: interleukin-2, None) , ( protein: hematopoietic cytokine, None) , ( protein: PI 3-kinase, None) , ( protein: phosphatidylinositol 3-kinase, None) , ( protein: E2F, None) , ( protein: IL-2, None) , ( cell type: T lymphocytes, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: interleukin-2, None) , ( protein: hematopoietic cytokine, None) , ( protein: PI 3-kinase, None) , ( protein: phosphatidylinositol 3-kinase, None) , ( protein: E2F, None) , ( protein: IL-2, None) , ( cell type: T lymphocytes, None) 