9070
Our studies show that the mechanism of IL-10 regulation of quiescent CD4(+) T-cell activation is mainly by blocking induction of IL-2 that is critical to downregulation of p27(Kip1) and upregulation of D cyclins in T-cell activation and entry into the cell cycle .
 ( protein: p27(Kip1), None) , ( protein: D cyclins, None) , ( protein: IL-2, None) , ( protein: IL-10, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: p27(Kip1), None) , ( protein: D cyclins, None) , ( protein: IL-2, None) , ( protein: IL-10, None) 