6490
In contrast to IL-12 , no up-regulation of IRF-1 was found in IL-4 -stimulated cells , and IL-4 did not block IL-12 -dependent up-regulation of IRF-1 .
 ( protein: IL-4, None) , ( cell line: IL-4 -stimulated cells, None) , ( protein: IRF-1, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( protein: IL-4, None) , ( protein: IRF-1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-4, None) , ( cell line: IL-4 -stimulated cells, None) , ( protein: IRF-1, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( protein: IL-4, None) , ( protein: IRF-1, None) 