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The tyrosine kinase inhibitors genistein and herbimycin A block both integrin -mediated tyrosine phosphorylation and increases in IL-1 beta message levels , indicating a causal relationship between the two events.
 ( protein: integrin, None) , ( protein: IL-1 beta, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: integrin, None) , ( protein: IL-1 beta, None) 