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We present a model for HIV replication in which the viral protease depletes the infected cells of bcl-2 , leading to oxidative stress-dependent activation of NF kappa B , a cellular factor required for HIV transcription , and ultimately to cell death .
 ( protein: cellular factor, None) , ( protein: viral protease, None) , ( protein: bcl-2, None) , ( protein: NF kappa B, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: cellular factor, None) , ( protein: viral protease, None) , ( protein: bcl-2, None) , ( protein: NF kappa B, None) 