10423
We here report that (i) like PML-RAR alpha expression , PLZF-RAR alpha expression blocks terminal differentiation of hematopoietic precursor cell lines ( U937 and HL-60 ) in response to different stimuli ( vitamin D3 , transforming growth factor beta1 , and dimethyl sulfoxide ); (ii) PML-RAR alpha , but not PLZF-RAR alpha , increases RA sensitivity of hematopoietic precursor cells and restores RA sensitivity of RA-resistant hematopoietic cells ; (iii) PML-RAR alpha and PLZF-RAR alpha have similar RA binding affinities; and (iv) PML-RAR alpha enhances the RA response of RA target genes (those for RAR beta , RAR gamma , and transglutaminase type II [ TGase ]) in vivo, while PLZF-RAR alpha expression has either no effect ( RAR beta ) or an inhibitory activity ( RAR gamma and type II TGase ).
 ( protein: RAR beta, None) , ( protein: PML-RAR alpha, None) , ( protein: PML-RAR alpha, None) , ( protein: TGase, None) , ( protein: type II TGase, None) , ( protein: RAR gamma, None) , ( protein: PLZF-RAR alpha, None) , ( cell type: RA-resistant hematopoietic cells, None) , ( protein: PML-RAR alpha, None) , ( cell type: hematopoietic precursor cells, None) , ( DNA: RA target genes, None) , ( protein: PLZF-RAR alpha, None) , ( protein: PLZF-RAR alpha, None) , ( protein: transglutaminase type II, None) , ( protein: PML-RAR alpha, None) , ( protein: RAR beta, None) , ( cell line: HL-60, None) , ( protein: TGase, None) , ( protein: RAR gamma, None) , ( cell line: U937, None) , ( protein: PLZF-RAR alpha, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: RAR beta, None) , ( protein: PML-RAR alpha, None) , ( protein: PML-RAR alpha, None) , ( protein: TGase, None) , ( protein: type II TGase, None) , ( protein: RAR gamma, None) , ( protein: PLZF-RAR alpha, None) , ( cell type: RA-resistant hematopoietic cells, None) , ( protein: PML-RAR alpha, None) , ( cell type: hematopoietic precursor cells, None) , ( DNA: RA target genes, None) , ( protein: PLZF-RAR alpha, None) , ( protein: PLZF-RAR alpha, None) , ( protein: transglutaminase type II, None) , ( protein: PML-RAR alpha, None) , ( protein: RAR beta, None) , ( cell line: HL-60, None) , ( protein: TGase, None) , ( protein: RAR gamma, None) , ( cell line: U937, None) , ( protein: PLZF-RAR alpha, None) 