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As AP-1 activity is regulated in part by activation of the c-Jun N-terminal kinase ( JNK ), which phosphorylates and subsequently increases the transcriptional activity of c-Jun, we examined whether LPS treatment of macrophages resulted in activation of this kinase .
 ( cell type: macrophages, None) , ( protein: kinase, None) , ( protein: c-Jun N-terminal kinase, None) , ( protein: JNK, None) , ( protein: AP-1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: macrophages, None) , ( protein: kinase, None) , ( protein: c-Jun N-terminal kinase, None) , ( protein: JNK, None) , ( protein: AP-1, None) 