6559
When a drug appears to be less effective than preclinical models suggest, can failures in effectiveness from delivery or dosing be differentiated? The disappointing results of clinical trials with IL-10 --so at odds with the prediction of benefit from animal models --bring into question the validity of those models as well as the soundness of design of the clinical trials on which efficacy of IL-10 is judged.
 ( protein: IL-10, None) , ( protein: IL-10, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-10, None) , ( protein: IL-10, None) 