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Since one of the few transcription factors which have been implicated in the regulation of monocyte genes is the macrophage- and B-cell-specific PU.1 transcription factor , we investigated whether PU.1 binds and activates the M-CSF receptor promoter .
 ( protein: transcription factors, None) , ( protein: M-CSF, None) , ( protein: PU.1, None) , ( DNA: monocyte genes, None) , ( protein: PU.1, None) , ( protein: transcription factor, None) , ( DNA: M-CSF receptor promoter, None) , ( protein: macrophage- and B-cell-specific PU.1, None) , ( protein: M-CSF receptor, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: transcription factors, None) , ( protein: M-CSF, None) , ( protein: PU.1, None) , ( DNA: monocyte genes, None) , ( protein: PU.1, None) , ( protein: transcription factor, None) , ( DNA: M-CSF receptor promoter, None) , ( protein: macrophage- and B-cell-specific PU.1, None) , ( protein: M-CSF receptor, None) 