8454
Briefly, we found that 1) rheumatoid synovial cells highly expressed CD44 ; 2) cross-linking of CD44 markedly but transiently augmented VCAM-1 expression and its mRNA transcription much more than did IL-1beta and TNF-alpha; 3) hyaluronan , especially when fragmented, also up-regulated VCAM-1 ; 4) CD44 activated the transcription factor AP-1; and 5) the integrin -dependent adhesive function of RA synovial cells to T cells was also amplified by CD44 cross-linking .
 ( protein: CD44, None) , ( protein: CD44, None) , ( protein: VCAM-1, None) , ( protein: CD44, None) , ( protein: CD44, None) , ( protein: integrin, None) , ( cell type: RA synovial cells, None) , ( cell type: rheumatoid synovial cells, None) , ( protein: VCAM-1, None) , ( protein: IL-1beta, None) , ( cell type: T cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CD44, None) , ( protein: CD44, None) , ( protein: VCAM-1, None) , ( protein: CD44, None) , ( protein: CD44, None) , ( protein: integrin, None) , ( cell type: RA synovial cells, None) , ( cell type: rheumatoid synovial cells, None) , ( protein: VCAM-1, None) , ( protein: IL-1beta, None) , ( cell type: T cells, None) 