11457
IL-4 treatment rapidly induced tyrosine phosphorylation of insulin receptor substrate (IRS)-1 and IRS-2 in 1D4 but not in E1C3 cells .
 ( cell line: E1C3 cells, None) , ( cell line: 1D4, None) , ( protein: insulin receptor substrate (IRS)-1, None) , ( protein: IRS-2, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell line: E1C3 cells, None) , ( cell line: 1D4, None) , ( protein: insulin receptor substrate (IRS)-1, None) , ( protein: IRS-2, None) 