11403
When used at differentiation-inducing concentrations, both topoisomerase inhibitors caused a great stimulation of AP-1 binding activity , with maximum value at hour 12 in etoposide -treated cells and at hour 48 in ICRF-193 -treated cells .
 ( protein: topoisomerase, None) , ( protein: AP-1, None) , ( cell type: ICRF-193 -treated cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: topoisomerase, None) , ( protein: AP-1, None) , ( cell type: ICRF-193 -treated cells, None) 