3453
These data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate I kappa B , and suggest one possible explanation for mechanism-based toxicities associated with FK-506 and CsA by demonstrating that these drugs can inhibit the calcineurin -dependent activation of a virtually ubiquitous transcription factor .
 ( protein: ubiquitous transcription factor, None) , ( protein: I kappa B, None) , ( protein: protein phosphatase, None) , ( protein: calcineurin, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: ubiquitous transcription factor, None) , ( protein: I kappa B, None) , ( protein: protein phosphatase, None) , ( protein: calcineurin, None) 