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To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.
 ( adverse event: presenting ,  25 additional patients with Wilson's disease: Subject, 25: Subject.Population, neurologic disease: Effect, penicillamine: Treatment, penicillamine: Treatment.Drug, Wilson's disease: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: presenting ,  25 additional patients with Wilson's disease: Subject, 25: Subject.Population, neurologic disease: Effect, penicillamine: Treatment, penicillamine: Treatment.Drug, Wilson's disease: Treatment.Disorder) 