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A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).
 ( adverse event: developed ,  A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck: Subject, 64 year old: Subject.Age, man: Subject.Gender, skin rash and bone marrow aplasia: Effect, a single dose of 40 mg/m2 methotrexate (MTX): Treatment, recurrent metastatic squamous cell carcinoma of the head and neck: Treatment.Disorder, 40 mg/m2: Treatment.Dosage, methotrexate: Treatment.Drug, a single dose: Treatment.Freq, 4 and 7 days: Treatment.Time_elapsed) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: developed ,  A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck: Subject, 64 year old: Subject.Age, man: Subject.Gender, skin rash and bone marrow aplasia: Effect, a single dose of 40 mg/m2 methotrexate (MTX): Treatment, recurrent metastatic squamous cell carcinoma of the head and neck: Treatment.Disorder, 40 mg/m2: Treatment.Dosage, methotrexate: Treatment.Drug, a single dose: Treatment.Freq, 4 and 7 days: Treatment.Time_elapsed) 