2452
The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.
 ( adverse event: leading ,  severe and even potentially fatal toxicities: Effect, itraconazole: Treatment, vincristine: Treatment, itraconazole: Treatment.Drug, vincristine: Treatment.Drug, itraconazole: Combination.Drug, vincristine: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: leading ,  severe and even potentially fatal toxicities: Effect, itraconazole: Treatment, vincristine: Treatment, itraconazole: Treatment.Drug, vincristine: Treatment.Drug, itraconazole: Combination.Drug, vincristine: Combination.Drug) 