6712
We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB -dependent in rheumatoid synovial tissue , in contrast to the main anti-inflammatory mediators , like IL -10 and -11 , and the IL-1 receptor antagonist .
 ( protein: NF-kappaB, None) , ( protein: cytokines, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: pro-inflammatory cytokines, None) , ( protein: anti-inflammatory mediators, None) , ( protein: IL-1 receptor antagonist, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: NF-kappaB, None) , ( protein: cytokines, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: pro-inflammatory cytokines, None) , ( protein: anti-inflammatory mediators, None) , ( protein: IL-1 receptor antagonist, None) 