11022
Reduction of IL-2 production is secondary to the inability to phosphorylate the cAMP response element binding protein , CREB , and induce expression of the immediate early genes such as Fos B that are required to transactivate the IL-2 promoter .
 ( protein: IL-2, None) , ( DNA: IL-2 promoter, None) , ( DNA: immediate early genes, None) , ( protein: CREB, None) , ( DNA: Fos B, None) , ( protein: IL-2, None) , ( protein: cAMP response element binding protein, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-2, None) , ( DNA: IL-2 promoter, None) , ( DNA: immediate early genes, None) , ( protein: CREB, None) , ( DNA: Fos B, None) , ( protein: IL-2, None) , ( protein: cAMP response element binding protein, None) 