10958
Altogether, our data demonstrate that: (a) the ability of B cells to release TNF-alpha after triggering of HLA-DR antigens depends on their stage of differentiation; (b) levels of released TNF-alpha seem to correlate with the stage of B-cell maturation but do not correlate with the amounts of cell surface HLA-DR antigens ; (c) secreted TNF-alpha regulates the levels of expression of NF-kappa B and AP-1 by an autocrine loop ; and (d) intracellular signals mediating TNF-alpha release by B cells are distinct from those regulating homotypic aggregation and proliferation .
 ( protein: TNF-alpha, None) , ( cell type: B cells, None) , ( protein: TNF-alpha, None) , ( protein: AP-1, None) , ( protein: cell surface HLA-DR antigens, None) , ( cell type: B cells, None) , ( protein: NF-kappa B, None) , ( protein: HLA-DR antigens, None) , ( protein: TNF-alpha, None) , ( protein: TNF-alpha, None) , ( protein: HLA-DR antigens, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: TNF-alpha, None) , ( cell type: B cells, None) , ( protein: TNF-alpha, None) , ( protein: AP-1, None) , ( protein: cell surface HLA-DR antigens, None) , ( cell type: B cells, None) , ( protein: NF-kappa B, None) , ( protein: HLA-DR antigens, None) , ( protein: TNF-alpha, None) , ( protein: TNF-alpha, None) , ( protein: HLA-DR antigens, None) 