1365
We highlight two instances of systemic allergic reaction, and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use.
 ( adverse event: of ,  two instances: Subject, two: Subject.Population, systemic allergic reaction: Effect, potential side effects: Effect, aprotinin: Treatment, aprotinin: Treatment.Drug, injections: Treatment.Route) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: of ,  two instances: Subject, two: Subject.Population, systemic allergic reaction: Effect, potential side effects: Effect, aprotinin: Treatment, aprotinin: Treatment.Drug, injections: Treatment.Route) 