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We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.
 ( potential therapeutic event: occurred ,  return of spontaneous circulation: Effect, epinephrine: Treatment, administration of the alpha-agonist metaraminol: Treatment, anaphylaxis under anaesthesia: Treatment.Disorder, metaraminol: Treatment.Drug, epinephrine: Treatment.Drug, epinephrine: Combination.Drug, metaraminol: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( potential therapeutic event: occurred ,  return of spontaneous circulation: Effect, epinephrine: Treatment, administration of the alpha-agonist metaraminol: Treatment, anaphylaxis under anaesthesia: Treatment.Disorder, metaraminol: Treatment.Drug, epinephrine: Treatment.Drug, epinephrine: Combination.Drug, metaraminol: Combination.Drug) 