3954
Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate ( TPA ) and tumour necrosis factor-alpha ( TNF-alpha ) upregulate ICAM-1 expression through the presence of a nuclear factor ( NF-kappa B ) target sequence ( TGGAAATTCC ).
 ( DNA: human ICAM-1 promoter, None) , ( protein: tumour necrosis factor-alpha, None) , ( protein: ICAM-1, None) , ( DNA: ICAM-1 promoter, None) , ( protein: TNF-alpha, None) , ( protein: ICAM-1, None) , ( DNA: nuclear factor ( NF-kappa B ) target sequence, None) , ( protein: nuclear factor, None) , ( protein: NF-kappa B, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( DNA: human ICAM-1 promoter, None) , ( protein: tumour necrosis factor-alpha, None) , ( protein: ICAM-1, None) , ( DNA: ICAM-1 promoter, None) , ( protein: TNF-alpha, None) , ( protein: ICAM-1, None) , ( DNA: nuclear factor ( NF-kappa B ) target sequence, None) , ( protein: nuclear factor, None) , ( protein: NF-kappa B, None) 