2355
Mutation of the major Sp1 binding site ( -110 bp ) decreased tissue-specific promoter activity, and these results, together with transactivation experiments , demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells .
 ( protein: CD14, None) , ( protein: Sp1, None) , ( protein: Sp1, None) , ( DNA: -110 bp, None) , ( DNA: major Sp1 binding site, None) , ( cell type: monocytic cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CD14, None) , ( protein: Sp1, None) , ( protein: Sp1, None) , ( DNA: -110 bp, None) , ( DNA: major Sp1 binding site, None) , ( cell type: monocytic cells, None) 