265
The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.
 ( adverse event: associated ,  in children with acute lymphoblastic leukemia: Subject, children: Subject.Age, varying degrees of neurotoxicity: Effect, The addition of intrathecal methotrexate to treatment protocols: Treatment, methotrexate: Treatment.Drug, acute lymphoblastic leukemia: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: associated ,  in children with acute lymphoblastic leukemia: Subject, children: Subject.Age, varying degrees of neurotoxicity: Effect, The addition of intrathecal methotrexate to treatment protocols: Treatment, methotrexate: Treatment.Drug, acute lymphoblastic leukemia: Treatment.Disorder) 