13546
Qualitatively different effects were observed for the IL-1 -induced activation of stress-activated protein (SAP) kinases : permanent overexpression of IRAK did not affect the dose dependence but prolonged the kinetics of IL-1 -induced activation of SAP kinases , suggesting that this signaling branch may be regulated by distinct mechanisms.
 ( protein: IL-1, None) , ( protein: stress-activated protein (SAP) kinases, None) , ( protein: IRAK, None) , ( protein: IL-1, None) , ( protein: SAP kinases, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: IL-1, None) , ( protein: stress-activated protein (SAP) kinases, None) , ( protein: IRAK, None) , ( protein: IL-1, None) , ( protein: SAP kinases, None) 