3848
Although the CRE site is necessary, optimal induction of bcl-2 expression requires participation of the upstream regulatory element , suggesting that phosphorylation of CREB alters its interaction with the upstream regulatory element .
 ( protein: CREB, None) , ( DNA: upstream regulatory element, None) , ( DNA: CRE site, None) , ( protein: bcl-2, None) , ( DNA: upstream regulatory element, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CREB, None) , ( DNA: upstream regulatory element, None) , ( DNA: CRE site, None) , ( protein: bcl-2, None) , ( DNA: upstream regulatory element, None) 