2862
Given that significant thyroid disorders may be only mildly symptomatic and thus may escape clinical detection, we suggest that thyroid function should be tested in any patient with otherwise unexplained changes in warfarin dose requirements, particularly if concomitantly treated with amiodarone.
 ( adverse event: changes ,  significant thyroid disorders: Effect, warfarin: Treatment, with amiodarone: Treatment, warfarin: Treatment.Drug, amiodarone: Treatment.Drug, amiodarone: Combination.Drug, warfarin: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: changes ,  significant thyroid disorders: Effect, warfarin: Treatment, with amiodarone: Treatment, warfarin: Treatment.Drug, amiodarone: Treatment.Drug, amiodarone: Combination.Drug, warfarin: Combination.Drug) 