5347
Two explanations for hyporesponsiveness of the human iNOS promoter to LPS +/- IFN-gamma were found: (1) multiple inactivating nucleotide substitutions in the human counterpart of the enhancer element that has been shown to regulate LPS / IFN-gamma induced expression of the mouse iNOS gene ; and (2) and absence of one or more nuclear factors in human macrophages (e.g., an LPS -inducible nuclear factor-kappa B/ Rel complex ), that is (are) required for maximal expression of the gene.
 ( protein: iNOS, None) , ( protein: LPS -inducible nuclear factor-kappa B/ Rel complex, None) , ( protein: nuclear factors, None) , ( protein: IFN-gamma, None) , ( protein: IFN-gamma, None) , ( DNA: human iNOS promoter, None) , ( protein: iNOS, None) , ( cell type: human macrophages, None) , ( protein: Rel, None) , ( DNA: mouse iNOS gene, None) , ( DNA: enhancer element, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: iNOS, None) , ( protein: LPS -inducible nuclear factor-kappa B/ Rel complex, None) , ( protein: nuclear factors, None) , ( protein: IFN-gamma, None) , ( protein: IFN-gamma, None) , ( DNA: human iNOS promoter, None) , ( protein: iNOS, None) , ( cell type: human macrophages, None) , ( protein: Rel, None) , ( DNA: mouse iNOS gene, None) , ( DNA: enhancer element, None) 