13234
To investigate whether both lipoxygenase isoforms exhibit a similar regulatory response toward cytokine stimulation , we studied the regulation of the leukocyte-type 12-lipoxygenase of murine peritoneal macrophages by interleukins and found that the activity of this enzyme is upregulated in a dose-dependent manner when the cells were cultured in the presence of the IL-4 or IL-13 but not by IL-10 .
 ( protein: interleukins, None) , ( protein: IL-4, None) , ( protein: cytokine, None) , ( cell type: murine peritoneal macrophages, None) , ( protein: IL-10, None) , ( cell type: peritoneal macrophages, None) , ( protein: lipoxygenase isoforms, None) , ( protein: leukocyte-type 12-lipoxygenase, None) , ( protein: enzyme, None) , ( protein: IL-13, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: interleukins, None) , ( protein: IL-4, None) , ( protein: cytokine, None) , ( cell type: murine peritoneal macrophages, None) , ( protein: IL-10, None) , ( cell type: peritoneal macrophages, None) , ( protein: lipoxygenase isoforms, None) , ( protein: leukocyte-type 12-lipoxygenase, None) , ( protein: enzyme, None) , ( protein: IL-13, None) 