10401
Expression of the gene encoding human inosine- 5'-monophosphate dehydrogenase (IMPDH) type II , an enzyme catalyzing the rate-limiting step in the generation of guanine nucleotides , is increased more than 10-fold in activated peripheral blood T lymphocytes and is required for T cell activation .
 ( protein: human inosine- 5#$%#-monophosphate dehydrogenase (IMPDH) type II, None) , ( cell type: activated peripheral blood T lymphocytes, None) , ( protein: enzyme, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: human inosine- 5#$%#-monophosphate dehydrogenase (IMPDH) type II, None) , ( cell type: activated peripheral blood T lymphocytes, None) , ( protein: enzyme, None) 