2015
Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.
 ( adverse event: resulted ,  Three patients: Subject, Three: Subject.Population, 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment): Effect, cytotoxic treatment, including high dose methotrexate with folinic acid rescue: Treatment, tumour: Treatment.Disorder, cytotoxic: Treatment.Drug, methotrexate: Treatment.Drug, folinic acid rescue: Treatment.Drug, high dose: Treatment.Dosage, folinic acid rescue: Combination.Drug, methotrexate: Combination.Drug, cytotoxic: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: resulted ,  Three patients: Subject, Three: Subject.Population, 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment): Effect, cytotoxic treatment, including high dose methotrexate with folinic acid rescue: Treatment, tumour: Treatment.Disorder, cytotoxic: Treatment.Drug, methotrexate: Treatment.Drug, folinic acid rescue: Treatment.Drug, high dose: Treatment.Dosage, folinic acid rescue: Combination.Drug, methotrexate: Combination.Drug, cytotoxic: Combination.Drug) 