10233
These results indicate that Bcl-2 acts downstream of MAPK kinase-1 but upstream of MAPK and suggest that, in the signaling pathway of the apoptotic process induced by bufalin , the transcriptional activity of activator protein-1 may be down-regulated through the inhibition of MAPK activity by Bcl-2 .
 ( protein: MAPK, None) , ( protein: Bcl-2, None) , ( protein: Bcl-2, None) , ( protein: activator protein-1, None) , ( protein: MAPK, None) , ( protein: MAPK kinase-1, None) , ( protein: MAPK, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: MAPK, None) , ( protein: Bcl-2, None) , ( protein: Bcl-2, None) , ( protein: activator protein-1, None) , ( protein: MAPK, None) , ( protein: MAPK kinase-1, None) , ( protein: MAPK, None) 