8643
In monocytic cells , IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity .
 ( cell type: monocytic cells, None) , ( protein: 5-LOX, None) , ( protein: 5-LOX enzyme, None) , ( protein: IL-1beta, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: monocytic cells, None) , ( protein: 5-LOX, None) , ( protein: 5-LOX enzyme, None) , ( protein: IL-1beta, None) 