7475
Treatment with E2 was also associated with a time-dependent decrease in the mRNA level of the proapoptotic Nip-2 protein , supporting the hypothesis that hormone responsiveness of U937 cells is mediated by target gene transcription.
 ( cell line: U937 cells, None) , ( protein: proapoptotic Nip-2 protein, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell line: U937 cells, None) , ( protein: proapoptotic Nip-2 protein, None) 