1474
Brain metastases are a frequent finding in patients with advanced non-small cell lung cancer and concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor is necessary in many cases.
 ( potential therapeutic event: necessary ,  patients with advanced non-small cell lung cancer: Subject, advanced non-small cell lung cancer: Subject.Disorder, concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor: Treatment, antiepileptic: Treatment.Drug, chemotherapeutic: Treatment.Drug, epidermal growth factor receptor (EGFR) inhibitor: Treatment.Drug, Brain metastases: Treatment.Disorder, antiepileptic: Combination.Drug, chemotherapeutic: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( potential therapeutic event: necessary ,  patients with advanced non-small cell lung cancer: Subject, advanced non-small cell lung cancer: Subject.Disorder, concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor: Treatment, antiepileptic: Treatment.Drug, chemotherapeutic: Treatment.Drug, epidermal growth factor receptor (EGFR) inhibitor: Treatment.Drug, Brain metastases: Treatment.Disorder, antiepileptic: Combination.Drug, chemotherapeutic: Combination.Drug) 