7824
CD40 ligation on MM by CD40L -transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6 , IL-8 , tumor necrosis factor-a , and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB .
 ( protein: CD40, None) , ( protein: tumor necrosis factor-a, None) , ( protein: CD40L, None) , ( protein: CD40L, None) , ( protein: nuclear factor kappaB, None) , ( protein: IL-8, None) , ( protein: granulocyte macrophage colony-stimulating factor, None) , ( protein: transcription factor, None) , ( protein: intercellular adhesion molecule-1, None) , ( protein: IL-6, None) , ( cell line: CD40L -transfected murine L-cells, None) , ( protein: CD40L fusion protein, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: CD40, None) , ( protein: tumor necrosis factor-a, None) , ( protein: CD40L, None) , ( protein: CD40L, None) , ( protein: nuclear factor kappaB, None) , ( protein: IL-8, None) , ( protein: granulocyte macrophage colony-stimulating factor, None) , ( protein: transcription factor, None) , ( protein: intercellular adhesion molecule-1, None) , ( protein: IL-6, None) , ( cell line: CD40L -transfected murine L-cells, None) , ( protein: CD40L fusion protein, None) 