731
The efficacy of single-dose disulfiram as an inhibitor of human P450 2E1 suggests that this modality for manipulating clinical P450 2E1 activity may provide a useful probe for delineating P450 2E1 participation in human drug biotransformation or for the treatment of poisoning by P450 2E1-activated toxins.
 ( adverse event: by ,  poisoning: Effect, P450 2E1-activated toxins: Treatment, disulfiram: Treatment.Drug, P450 2E1-activated toxins: Treatment.Drug, single-dose: Treatment.Dosage) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: by ,  poisoning: Effect, P450 2E1-activated toxins: Treatment, disulfiram: Treatment.Drug, P450 2E1-activated toxins: Treatment.Drug, single-dose: Treatment.Dosage) 