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A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.
 ( adverse event: developed ,  A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma: Subject, hereditary retinoblastoma: Subject.Disorder, cerebral edema and brainstem herniation: Effect, a single dose of intravenous methotrexate: Treatment, intracranial osteosarcoma: Treatment.Disorder, a single dose: Treatment.Freq, intravenous: Treatment.Route, methotrexate: Treatment.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: developed ,  A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma: Subject, hereditary retinoblastoma: Subject.Disorder, cerebral edema and brainstem herniation: Effect, a single dose of intravenous methotrexate: Treatment, intracranial osteosarcoma: Treatment.Disorder, a single dose: Treatment.Freq, intravenous: Treatment.Route, methotrexate: Treatment.Drug) 