6200
Estrogens affect vascular tone indirectly by modulating release of endothelium-derived vasoactive factors and directly by modulating intracellular calcium in vascular smooth muscle cells .
 ( cell type: vascular smooth muscle cells, None) , ( protein: endothelium-derived vasoactive factors, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: vascular smooth muscle cells, None) , ( protein: endothelium-derived vasoactive factors, None) 