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We took advantage of our monoclonal model of germinal center B cell differentiation , IgM+ IgD+ CL-01 cells , to define the role of the I gamma 3 evolutionarily conserved sequence ( ECS ) in the germline transcriptional activation of the human C gamma 3 gene .
 ( DNA: evolutionarily conserved sequence, None) , ( DNA: germline, None) , ( protein: I gamma 3, None) , ( cell type: germinal center B cell, None) , ( cell line: IgM+ IgD+ CL-01 cells, None) , ( DNA: ECS, None) , ( DNA: human C gamma 3 gene, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( DNA: evolutionarily conserved sequence, None) , ( DNA: germline, None) , ( protein: I gamma 3, None) , ( cell type: germinal center B cell, None) , ( cell line: IgM+ IgD+ CL-01 cells, None) , ( DNA: ECS, None) , ( DNA: human C gamma 3 gene, None) 