7374
From these studies, we conclude that a concerted action of the transcription factors AP-2 and Sp1 is essential for the up -regulation of ASM expression during the process of macrophage differentiation .
 ( protein: transcription factors, None) , ( protein: Sp1, None) , ( protein: AP-2, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: transcription factors, None) , ( protein: Sp1, None) , ( protein: AP-2, None) 