1070
Present results suggested that coadministration of mexiletine increased blood tizanidine concentrations and enhanced tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms.
 ( potential therapeutic event: enhanced ,  tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms: Effect, coadministration of mexiletine increased blood tizanidine concentrations: Treatment, mexiletine: Treatment.Drug, tizanidine: Treatment.Drug, mexiletine: Combination.Drug, tizanidine: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( potential therapeutic event: enhanced ,  tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms: Effect, coadministration of mexiletine increased blood tizanidine concentrations: Treatment, mexiletine: Treatment.Drug, tizanidine: Treatment.Drug, mexiletine: Combination.Drug, tizanidine: Combination.Drug) 