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We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.
 ( potential therapeutic event: initiation ,  three patients: Subject, three: Subject.Population, profound reduction in plasma HDL cholesterol and apolipoprotein AI levels: Effect, rosiglitazone therapy: Treatment, rosiglitazone: Treatment.Drug, soon after: Treatment.Time_elapsed, preexisting diabetic dyslipidemia: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( potential therapeutic event: initiation ,  three patients: Subject, three: Subject.Population, profound reduction in plasma HDL cholesterol and apolipoprotein AI levels: Effect, rosiglitazone therapy: Treatment, rosiglitazone: Treatment.Drug, soon after: Treatment.Time_elapsed, preexisting diabetic dyslipidemia: Treatment.Disorder) 