4315
Downregulation of LPS-induced AP-1 was accompanied, and thus possibly explained, by a reduced expression at mRNA level of the two major components of the AP-1 complex , namely c-fos and c-jun as determined by Northern experiments .
 ( protein: AP-1, None) , ( RNA: mRNA, None) , ( protein: AP-1 complex, None) , ( DNA: c-jun, None) , ( protein: LPS-induced AP-1, None) , ( protein: AP-1, None) , ( DNA: c-fos, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: AP-1, None) , ( RNA: mRNA, None) , ( protein: AP-1 complex, None) , ( DNA: c-jun, None) , ( protein: LPS-induced AP-1, None) , ( protein: AP-1, None) , ( DNA: c-fos, None) 