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All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.
 ( adverse event: appeared.,  All patients: Subject, skin lesions: Effect, phenytoin for variable time periods (range 16-80 days; mean: 40): Treatment, phenytoin: Treatment.Drug, 16-80 days;: Treatment.Duration, 40: Treatment.Duration) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: appeared.,  All patients: Subject, skin lesions: Effect, phenytoin for variable time periods (range 16-80 days; mean: 40): Treatment, phenytoin: Treatment.Drug, 16-80 days;: Treatment.Duration, 40: Treatment.Duration) 