12765
Taken together, our findings indicate that signaling via CD27 on B cells induces IgE synthesis , in cooperation with IL-4 and CD40 signaling, by promoting the generation of plasma cells through up-regulation of positive regulatory domain I-binding factor-1 .
 ( protein: positive regulatory domain I-binding factor-1, None) , ( cell type: plasma cells, None) , ( protein: IL-4, None) , ( protein: IgE, None) , ( protein: CD40, None) , ( cell type: B cells, None) , ( protein: CD27, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: positive regulatory domain I-binding factor-1, None) , ( cell type: plasma cells, None) , ( protein: IL-4, None) , ( protein: IgE, None) , ( protein: CD40, None) , ( cell type: B cells, None) , ( protein: CD27, None) 