7568
These data indicate that thrombin activates endothelial ICAM-1 expression and polymorphonuclear leukocyte adhesion by NF-kappa Bp65 binding to the downstream NF-kappa B site of ICAM-1 promoter after proteolytically activated receptor-1 activation .
 ( cell type: polymorphonuclear leukocyte, None) , ( protein: NF-kappa Bp65, None) , ( DNA: ICAM-1 promoter, None) , ( protein: ICAM-1, None) , ( protein: ICAM-1, None) , ( DNA: NF-kappa B site, None) , ( protein: thrombin, None) , ( protein: NF-kappa B, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: polymorphonuclear leukocyte, None) , ( protein: NF-kappa Bp65, None) , ( DNA: ICAM-1 promoter, None) , ( protein: ICAM-1, None) , ( protein: ICAM-1, None) , ( DNA: NF-kappa B site, None) , ( protein: thrombin, None) , ( protein: NF-kappa B, None) 