4391
Finally, the biological relevance of the observation that T. pallidum lipoproteins -lipopeptides induce both NF-kappa B and cytokine production in monocytes was supported by the ability of the synthetic analogs to promote human immunodeficiency virus replication in chronically infected U1 monocytoid cells; these observations also suggest a potential mechanism whereby a syphilitic chancre can serve as a cofactor for human immunodeficiency virus transmission .
 ( protein: T. pallidum lipoproteins, None) , ( cell type: monocytes, None) , ( protein: cytokine, None) , ( protein: NF-kappa B, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: T. pallidum lipoproteins, None) , ( cell type: monocytes, None) , ( protein: cytokine, None) , ( protein: NF-kappa B, None) 