7676
Furthermore, there was no increase in cyclin D-associated kinase activity upon HLA class I ligation , suggesting that cyclin E-dependent kinase activity mediates Rb inactivation, leading to E2F activation and cell proliferation .
 ( protein: cyclin D-associated kinase, None) , ( protein: cyclin E-dependent kinase, None) , ( protein: HLA class I, None) , ( protein: E2F, None) , ( protein: Rb, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: cyclin D-associated kinase, None) , ( protein: cyclin E-dependent kinase, None) , ( protein: HLA class I, None) , ( protein: E2F, None) , ( protein: Rb, None) 