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Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.
 ( adverse event: toxicity ,  PPE: Effect, high-dose cytarabine: Treatment, high-dose: Treatment.Dosage, cytarabine: Treatment.Drug, haematologic malignancies: Treatment.Disorder) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: toxicity ,  PPE: Effect, high-dose cytarabine: Treatment, high-dose: Treatment.Dosage, cytarabine: Treatment.Drug, haematologic malignancies: Treatment.Disorder) 