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Although ICAM-1 induction was unaffected, inhibitors of NADPH oxidase ( apocynin ) or cytochrome P-450 ( SKF525a ) suppressed VCAM-1 induction by TNF, revealing that several radical-generating systems are involved in its regulation.
 ( protein: NADPH oxidase, None) , ( protein: cytochrome P-450, None) , ( protein: ICAM-1, None) , ( protein: VCAM-1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: NADPH oxidase, None) , ( protein: cytochrome P-450, None) , ( protein: ICAM-1, None) , ( protein: VCAM-1, None) 