2008
Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.
 ( adverse event: noted.,  Markedly increased pigmementation of skin immediately overlying veins: Effect, multiple 5-fluorouracil infusions: Treatment, 5-fluorouracil: Treatment.Drug, infusions: Treatment.Route) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: noted.,  Markedly increased pigmementation of skin immediately overlying veins: Effect, multiple 5-fluorouracil infusions: Treatment, 5-fluorouracil: Treatment.Drug, infusions: Treatment.Route) 