6050
However, disruption of a membrane-proximal proline-rich sequence motif (' box1 ') in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3 , but also IL-4 -triggered activation of STAT5 and concomitant cell proliferation .
 ( protein: box1, None) , ( protein: bipartite IL-4R, None) , ( protein: JAK3, None) , ( protein: STAT5, None) , ( protein: JAK1, None) , ( protein: Janus kinases, None) , ( protein: membrane-proximal proline-rich sequence motif, None) , ( protein: IL-4, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: box1, None) , ( protein: bipartite IL-4R, None) , ( protein: JAK3, None) , ( protein: STAT5, None) , ( protein: JAK1, None) , ( protein: Janus kinases, None) , ( protein: membrane-proximal proline-rich sequence motif, None) , ( protein: IL-4, None) 