4194
We conclude, rather, that alpha 4 beta 1 in freshly isolated T cells delivers a distinct signal that synergizes early with signals initiated by TCR/CD3 ligation to induce DNA binding of multiple transcription factors required for cytokine gene induction .
 ( protein: TCR/CD3, None) , ( protein: transcription factors, None) , ( cell type: freshly isolated T cells, None) , ( DNA: cytokine gene, None) , ( protein: alpha 4 beta 1, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: TCR/CD3, None) , ( protein: transcription factors, None) , ( cell type: freshly isolated T cells, None) , ( DNA: cytokine gene, None) , ( protein: alpha 4 beta 1, None) 