2005
Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.
 ( adverse event: reported ,  reserpine toxicity, in particular central nervous system (CNS) disturbances: Effect, additive CNS effects: Effect, reserpine: Treatment, also receiving barbiturates,: Treatment, barbiturates: Treatment.Drug, reserpine: Treatment.Drug, barbiturates: Combination.Drug, reserpine: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: reported ,  reserpine toxicity, in particular central nervous system (CNS) disturbances: Effect, additive CNS effects: Effect, reserpine: Treatment, also receiving barbiturates,: Treatment, barbiturates: Treatment.Drug, reserpine: Treatment.Drug, barbiturates: Combination.Drug, reserpine: Combination.Drug) 