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On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.
 ( adverse event: developed ,  bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death: Effect, high dose of ARA-C: Treatment, ARA-C: Treatment.Drug, high dose: Treatment.Dosage, 2 g/m2: Treatment.Dosage, the fifth day: Treatment.Time_elapsed, the 22nd day: Treatment.Time_elapsed, 12 hours: Treatment.Freq) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: developed ,  bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death: Effect, high dose of ARA-C: Treatment, ARA-C: Treatment.Drug, high dose: Treatment.Dosage, 2 g/m2: Treatment.Dosage, the fifth day: Treatment.Time_elapsed, the 22nd day: Treatment.Time_elapsed, 12 hours: Treatment.Freq) 