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In this report we present evidence that the cell line NK3.3 derived from human NK cells , responds to both IL-2 and IL-12 , as measured by increases in IFN-gamma and granulocyte-macrophage colony-stimulating factor ( GM-CSF ) cytoplasmic mRNA and protein expression .
 ( protein: GM-CSF, None) , ( protein: IFN-gamma, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: human NK cells, None) , ( protein: IL-12, None) , ( protein: IL-2, None) , ( cell line: cell line NK3.3, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: GM-CSF, None) , ( protein: IFN-gamma, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: human NK cells, None) , ( protein: IL-12, None) , ( protein: IL-2, None) , ( cell line: cell line NK3.3, None) 