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The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.
 ( potential therapeutic event: disappeared ,  2 of the women: Subject, 2: Subject.Population, women: Subject.Gender, polycystic changes disappeared from the ovaries: Effect, lost weight and resumed menstruating: Effect, after valproate therapy was discontinued: Treatment, valproate: Treatment.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( potential therapeutic event: disappeared ,  2 of the women: Subject, 2: Subject.Population, women: Subject.Gender, polycystic changes disappeared from the ovaries: Effect, lost weight and resumed menstruating: Effect, after valproate therapy was discontinued: Treatment, valproate: Treatment.Drug) 