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We show here that the plasma cell-specific repressor function , designated SIR ( suppressor of immune response genes ), does not act directly on the transcription of class II genes , but instead on the transcription of the AIR-1 gene , whose product, the class II transactivator ( CIITA ), is fundamental for the regulation of the constitutive and inducible expression of MHC class II genes .
 ( DNA: MHC class II genes, None) , ( DNA: suppressor of immune response genes, None) , ( protein: CIITA, None) , ( DNA: class II genes, None) , ( DNA: class II genes, None) , ( DNA: AIR-1 gene, None) , ( DNA: SIR, None) , ( protein: class II transactivator, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( DNA: MHC class II genes, None) , ( DNA: suppressor of immune response genes, None) , ( protein: CIITA, None) , ( DNA: class II genes, None) , ( DNA: class II genes, None) , ( DNA: AIR-1 gene, None) , ( DNA: SIR, None) , ( protein: class II transactivator, None) 