14654
The induced differentiation occurs with down-regulation of c-fos protein and an accompanying up-regulation of RB protein expression , consistent with a possible need for up-regulated RB expression to maintain a given differentiated phenotype and suppress transcriptional activators that might typically be associated with proliferation.
 ( protein: RB protein, None) , ( protein: transcriptional activators, None) , ( protein: c-fos protein, None) , ( protein: RB, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: RB protein, None) , ( protein: transcriptional activators, None) , ( protein: c-fos protein, None) , ( protein: RB, None) 