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Costimulation of human CD4+ T cells with LFA-3 and B7 induce distinct effects on AP-1 and NF-kappa B transcription factors .
 ( protein: LFA-3, None) , ( protein: transcription factors, None) , ( cell line: human CD4+ T cells, None) , ( protein: NF-kappa B, None) , ( protein: AP-1, None) , ( protein: B7, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: LFA-3, None) , ( protein: transcription factors, None) , ( cell line: human CD4+ T cells, None) , ( protein: NF-kappa B, None) , ( protein: AP-1, None) , ( protein: B7, None) 