2439
Replicate brain magnetic resonance imaging examinations after six weeks and 11 months of penicillamine therapy documented the development of new brain lesions during this period, while liver biopsy specimen data disclosed that excellent hepatic decoppering had occurred.
 ( adverse event: development ,  new brain lesions: Effect, six weeks and 11 months of penicillamine therapy: Treatment, six weeks and 11 months: Treatment.Duration, penicillamine: Treatment.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: development ,  new brain lesions: Effect, six weeks and 11 months of penicillamine therapy: Treatment, six weeks and 11 months: Treatment.Duration, penicillamine: Treatment.Drug) 