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In both T cells and HeLa cells HIV-1 Tat suppressed the expression of Mn-dependent superoxide dismutase ( Mn-SOD ), a mitochondrial enzyme that is part of the cellular defense system against oxidative stress .
 ( cell line: HeLa cells, None) , ( protein: HIV-1 Tat, None) , ( protein: mitochondrial enzyme, None) , ( protein: Mn-SOD, None) , ( protein: Mn-dependent superoxide dismutase, None) , ( cell type: T cells, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell line: HeLa cells, None) , ( protein: HIV-1 Tat, None) , ( protein: mitochondrial enzyme, None) , ( protein: Mn-SOD, None) , ( protein: Mn-dependent superoxide dismutase, None) , ( cell type: T cells, None) 