6481
IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells ; however, relatively few IL-12 target genes have been identified.
 ( cell type: Th1 cells, None) , ( cell type: CD4+ cells, None) , ( protein: critical immunoregulatory cytokine, None) , ( protein: IL-12, None) , ( protein: IL-12, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: Th1 cells, None) , ( cell type: CD4+ cells, None) , ( protein: critical immunoregulatory cytokine, None) , ( protein: IL-12, None) , ( protein: IL-12, None) 