12473
Since the AES proteins are part of a set of transcriptional repressors encoded by the Enhancer of split [E(spl)] genes , and since these repressors are activated to suppress cell differentiation in response to Notch receptors signalling, the AES peptides may represent a novel class of self-antigens that deserve further consideration as tumor Ag in epithelial cancers .
 ( protein: Notch receptors, None) , ( protein: AES proteins, None) , ( protein: tumor Ag, None) , ( protein: self-antigens, None) , ( DNA: Enhancer of split [E(spl)] genes, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: Notch receptors, None) , ( protein: AES proteins, None) , ( protein: tumor Ag, None) , ( protein: self-antigens, None) , ( DNA: Enhancer of split [E(spl)] genes, None) 