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The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.
 ( adverse event: given ,  hepatotoxicity developed: Effect, vincristine and actinomycin D: Treatment, vincristine: Treatment.Drug, actinomycin D: Treatment.Drug, vincristine: Combination.Drug, actinomycin D: Combination.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: given ,  hepatotoxicity developed: Effect, vincristine and actinomycin D: Treatment, vincristine: Treatment.Drug, actinomycin D: Treatment.Drug, vincristine: Combination.Drug, actinomycin D: Combination.Drug) 