12518
While the activation of the IL-2 promoter and an NFAT -driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418 , it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2 -mediated NFAT activation is under the control of a combination of calcineurin- dependent and independent pathways .
 ( protein: Tpl-2, None) , ( protein: calcineurin, None) , ( DNA: NFAT -driven minimal promoter, None) , ( DNA: IL-2 promoter, None) , ( protein: NFAT delta418, None) , ( protein: IL-2, None) , ( protein: NFAT, None) , ( protein: Tpl-2, None) , ( protein: NFAT, None) , ( protein: NFAT, None) , ( protein: dominant negative mutant, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: Tpl-2, None) , ( protein: calcineurin, None) , ( DNA: NFAT -driven minimal promoter, None) , ( DNA: IL-2 promoter, None) , ( protein: NFAT delta418, None) , ( protein: IL-2, None) , ( protein: NFAT, None) , ( protein: Tpl-2, None) , ( protein: NFAT, None) , ( protein: NFAT, None) , ( protein: dominant negative mutant, None) 