5837
Transient transfection studies in HeLa cells , an E(2) receptor-negative line, suggest that E(2) inhibits TNF gene expression through an effect mediated by estrogen receptor beta ( ERbeta ).
 ( protein: ERbeta, None) , ( protein: estrogen receptor beta, None) , ( cell line: HeLa cells, None) , ( protein: TNF, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: ERbeta, None) , ( protein: estrogen receptor beta, None) , ( cell line: HeLa cells, None) , ( protein: TNF, None) 