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We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.
 ( adverse event: development ,  3 patients: Subject, 3: Subject.Population, cutaneous scleroderma: Effect, the use of bleomycin in low cumulative doses of less than 100 U.: Treatment, bleomycin: Treatment.Drug, less than 100 U.: Treatment.Dosage) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: development ,  3 patients: Subject, 3: Subject.Population, cutaneous scleroderma: Effect, the use of bleomycin in low cumulative doses of less than 100 U.: Treatment, bleomycin: Treatment.Drug, less than 100 U.: Treatment.Dosage) 