8384
Thus, ligation of CD28 with either CD80 or CD86 leads to shared early signal transduction events such as the tyrosine phosphorylation of CBL and VAV , to NFAT -mediated transcriptional activation, and to the costimulation of interleukin-2 and granulocyte-macrophage colony-stimulating factor production .
 ( protein: VAV, None) , ( protein: CD80, None) , ( protein: CD86, None) , ( protein: NFAT, None) , ( protein: interleukin-2, None) , ( protein: CD28, None) , ( protein: CBL, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: VAV, None) , ( protein: CD80, None) , ( protein: CD86, None) , ( protein: NFAT, None) , ( protein: interleukin-2, None) , ( protein: CD28, None) , ( protein: CBL, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) 