2663
This study revealed that ketoconazole affected the disposition of rosiglitazone in humans, probably by the inhibition of CYP2C8 and CYP2C9, leading to increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events.
 ( adverse event: leading to ,  humans: Subject, increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events: Effect, ketoconazole: Treatment, ketoconazole: Treatment.Drug) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: adverse event,potential therapeutic event, Arguments type: Treatment.Disorder,Treatment.Time_elapsed,Treatment.Dosage,Subject.Race,Treatment.Drug,Treatment.Route,Subject.Disorder,Treatment.Freq,Treatment,Effect,Subject.Population,Treatment.Duration,Combination.Drug,Subject,Subject.Age,Subject.Gender. 
Text: {0} 
Answer:
 ( adverse event: leading to ,  humans: Subject, increasing rosiglitazone concentrations that could increase the efficacy of rosiglitazone or its adverse events: Effect, ketoconazole: Treatment, ketoconazole: Treatment.Drug) 