568
Taken together, these data point to a potential mechanism underlying EBV -mediated B cell transformation whereby constitutive induction of key cell cycle regulators by LMP-1 can lead to pRb hyperphosphorylation and uncontrolled cell proliferation .
 ( protein: key cell cycle regulators, None) , ( protein: LMP-1, None) , ( protein: pRb, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: key cell cycle regulators, None) , ( protein: LMP-1, None) , ( protein: pRb, None) 