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Our studies now demonstrate that HTLV-1 Tax activates the recently identified cellular kinases IkappaB kinase alpha ( IKKalpha ) and IKKbeta , which normally phosphorylate IkappaB alpha on both of its N-terminal regulatory serines in response to tumor necrosis factor alpha ( TNF-alpha ) and interleukin-1 ( IL-1 ) stimulation .
 ( protein: TNF-alpha, None) , ( protein: interleukin-1, None) , ( protein: IkappaB kinase alpha, None) , ( protein: cellular kinases, None) , ( protein: IL-1, None) , ( protein: IkappaB alpha, None) , ( protein: Tax, None) , ( protein: IKKbeta, None) , ( protein: IKKalpha, None) , ( protein: tumor necrosis factor alpha, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( protein: TNF-alpha, None) , ( protein: interleukin-1, None) , ( protein: IkappaB kinase alpha, None) , ( protein: cellular kinases, None) , ( protein: IL-1, None) , ( protein: IkappaB alpha, None) , ( protein: Tax, None) , ( protein: IKKbeta, None) , ( protein: IKKalpha, None) , ( protein: tumor necrosis factor alpha, None) 