811
Whereas PHA -induced proliferation of PBMCs derived from patients with breast cancer preoperatively was significantly decreased when compared with data obtained in healthy control individuals (P < 0.001), the degree of the defect in PHA -induced proliferation of PBMCs depended upon the tumour burden as manifested by tumour size and axillary lymph node involvement (P < 0.003 in each case).
 ( cell type: PBMCs, None) , ( protein: PHA, None) , ( protein: PHA, None) , ( cell type: PBMCs, None) 
Locate the role in the text that participated in the event based on the event type and return it in the event list. 
 Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . 
Text: {0} 
Answer:
 ( cell type: PBMCs, None) , ( protein: PHA, None) , ( protein: PHA, None) , ( cell type: PBMCs, None) 