Antibiotic Identified by AI
Pretty well done - especially the experimental validation.  The main conclusions are accurate, but there is some BS around the periphery.  A few notes below.- The secret sauce here was the large, high quality experimental dataset they generated.- Chemprop is meh.- Is a tanimoto similarity - The cheminformatic filtering steps that they did on their hits was well done.- The experimental validation of the target was well done.  A good illustration of all the preclinical work it takes to validate a molecule and mechanism on the way to an IND.- They got very lucky.  Most of the time your compound hits are not all that potent and require extensive med chem optimization.  That was not the case here.