Nearly 1 in 3 drugs have a significant safety issue after FDA approval
In one of my favorite books, Antifragile, Nassim Taleb argues that health is largely subtractive - if you want to be healthy, remove unnatural things from your body (sugar, medicines, sitting too much, etc), and only undergo surgery, go to the hospital, or take medicine in very serious cases where the harm of not doing something outweighs the potential complications.  Especially since hearing more about more about how the American health system is not exactly incentivized to always look out for the best interest of the patient, I'm inclined to agree with him.