We now have an effective vaccine for Malaria
It sounds like this vaccine should be combined with some of the mosquito eradication methods highlighted in a recent HN link [1]. One commenter there ("Ox12") pointed to an article in Nature which argues the reduction in mosquito population would likely not be problematic.1: http://news.ycombinator.com/item?id=3043065
2: http://www.nature.com/news/2010/100721/full/466432a.html