Steve Yegge quits Google in the middle of his speech [OSCON Data 2011]
So I'm not really an ask me anything type guy, but I work on a bioinformatics team at an academic cancer research center.  We have genomic sequencers and a software stack running 24/7/365 plus your normal collection of IT and small dev projects here.If you have questions about what it's like to be a hacker in this type of environment, post them here and I'll share what my experience is like.BTW, I completely wish I knew more stats and bioinformatics, so I probably should purchase the Yegge book collection myself . . .