We Made One Gram Of Remdesivir
In my former life I was a graduate organic chemist, but I “quit” with a Masters.  I loved Synthetic Chemistry as an undergrad and thought I wanted a PhD in.  There were three lousy things (for me) about the career that made me bail.1).  So many syntheses have horrible yields just like this one.  You’d start with grams of material to end up with micrograms.  I loved solving these problems as an undergrad in books, but reality was far different.  You don’t think much about side products until you start doing novel chemistry.2). So much trial and error.  There were happy go lucky chemists that fell into projects that were smooth as butter, while brilliant chemists would toil 12 hour days to try and something to write up as a thesis.  I was neither brilliant nor lucky and took 4 different projects over two years before finally landing on something marginally MS worthy.  They need a journal of failed chemistry because only the working stuff gets published.  So many failures could be logged so I didn’t waste my time doing non-working or poor yielding reactions.3). Suspicious results in journals.  I would read about a reaction and someone would put a 75% yield as their result and I could barely get 20.  I always thought I was just bad, but a really smart chemist challenged me one day and tried to do it himself and couldn’t do much better.  He tried it 30 different ways over the year as he did other stuff.  He never could get a good yield.  We talked to our advisor and we wanted to challenge the result, but the advisor didn’t want to start trouble.  It was past the time I decided to leave with a masters, but made me feel a little better about my lousy abilities.  No one could ever possibly doublecheck every result from every publication anyways.All this said, there are some brilliant and patient scientists out there that drive the field forward.  Just a few rough around the edge items I’d love to see change.