Native Clojure with GraalVM
GraalVM is very impressive. But clojure is very much associated with Java/JVM Ecosystem which makes it very hard to  convince people to use it. My ruby friends would say oh i cant install clojure because i have to install JVM. Clojurescript like lumo or planck is still better, but it isnt a real backend solution. Clojurescript is great for the frontend though. I think clojure needs a native solution written in Clojure + LLVM that leverages existing C-libs. A seperate JIT/compiler that is not JVM, that is not a language with Borrowed GC + VM.