Alterations in glutamate and the experience of ego dissolution with psilocybin
Totally anecdotal but LSD made my depression significantly worse than improving it in any way. I had two proper trips and had a seizure kind of thing at the start of the second one due to the overwhelming visuals (not experienced anything like that before or since).EDIT: to expand, it made me very questioning of my own consciousness and gave me severe and persistent existential dread and fear of death to the point where I felt quite suicidal (which I've _never_ experienced before). I restarted my old anti-depressants which have helped quite a lot but I don't think these feelings will ever truly disappear. Quite honestly it is the one drug I truly regret taking. If you aren't ready to accept what these drugs will show you then it can be a long-lasting and damaging experience, certainly it was for me