Less.js will obsolete CSS
Running a compiler in the browser in production will never be a good idea. If you care about the speed that your website displays -- and you should -- the slowdown caused by parsing, processing, and concatenating large amounts of CSS will dwarf over-the-wire time. People who seriously care about the usability of their sites have been spending a lot of effort recently figuring out how to get load times as fast as possible, and this is a leap in the wrong direction.