The James Webb Space Telescope is finding too many early galaxies
I don't know if this instance qualifies as one, but I think its fair to say that cosmology is the one domain of "fundamental" physics where "discrepancies" or question marks keep piling up and not really resolving.It the pattern of previous science revolutions repeats, there could come a point where reinterpreting the large existing body of knowledge using a different paradigm would explain an number of "oddities" in a more economical way.I don't know if this generation of telescopes will get us there but it feels that this is a plausible outcome over the next 1-2 decades. Which would be very exciting :-)