You can bypass YouTube ads by adding a dot after the domain
Reminds me of a solvent metaphor for adblockers.Ads on web pages are like stains on a surface.Browsing with ublock origin is like cleaning a surface with alcohol-based product. It worked for a while.Cat-and-mouse game tends to yield ads that bypass these. Like sticky dirt that won't go away with alcohol.Enters uMatrix.
Browsing with uMatrix is like cleaning the surface with a mix of stronger solvents, like acetone.  It's much more effective, but it will more or less ruin the surface/web page in many cases.Tuning uMatrix allows to find a mix that works.
For geeks that are okay with contributing, or just clicking on colored cells in a grid, uMatrix is best.  Like wolves, ads bite the laziest part of the flock, leaving the strongest clear.