It's Never Too Late to Learn Guitar
Warning! If you're middle-aged and thinking of picking up the guitar, you should realize that the public image of guitarists has shifted from "sexy gods" to "annoying hobos" sometime in the last two decades. If you are at least partly motivated by popularity (and who isn't), maybe pick another hobby that actually helps people be popular now, not in your imagined past. So in a sense, yes, it is sometimes too late :-(