Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [pdf]
Assuming that psilocybin is effective at treating depression, I find myself wondering whether actual conscious experience (that is, being high) is an essential part of its effectiveness or not.To put this another way, imagine someone takes whatever dose of psilocybin and then is rendered unconsciousness until the perceptual effects wear off.  Will there be any difference in its effectiveness as a treatment for depression?