It is the system of antigenic system material is used to arouse an individual immune system to prevent the pathogens. Vaccines are the preventive measures of infectious diseases. The Influence of the vaccines are been promoted worldwide. This is one of the methods of preventing infectious diseases more effectively. By using, vaccination method we have prevented many diseases, such as smallpox. The vaccine of small pox was discovered by the Louis pasture. Through this lead of vaccine we have eradicated small pox by 1979. In cancer the tumor antigen led a path towards antigen specific immunotherapy of cancer. Today anti – tumor vaccination haven't reached its promise destination. This happens because of the failure includes tumor immune escape mechanism, limitations in availability of tumor specific antigens in the destination immunological context.