Already staked to a 3-0 advantage after one frame, Ingram struck out five batters in the first two innings.
Jordi Harre and Mackenzie McFeron each reached base on singles against Tori Witruk to open the contest. Emily Thompson stepped in and smacked a line drive to center field, which brought home two runs.
Brooke Burcham added an RBI double in the first frame for Nashville. McFeron drove in a run in the second inning for a 4-0 lead, and that was more than enough for Ingram, who eclipsed 400 strikeouts for the season in this game.
The Spartans' Ashlynn McConaha laid down a bunt single in the sixth inning to break up Ingram's no-hit bid.
The Nashville seniors won it all in 2012 and claimed third in the state in 2013.
Nashville (38-2) takes on Brimfield (32-5-1) for the state championship at 5:30 p.m. Saturday.