Evicted from the regular student dorms for adopting stray cats, Sorata Kanada now resides in Room 101 of Sakura Hall, where the weirdos, geniuses, and troublemakers live. His teacher Chihiro gives him the daunting tasks of taking care of and teaching her younger cousin, Mashiro Shiina (who will be living in Room 202 of Sakura Hall), the necessary basics skills of surviving daily life. Being a child prodigy of the art world, all of her daily needs were taken care of so she's dysfunctional.