The definition of border disease: problems for the diagnostician.
R. M. Barlow*, J. T. Vantsis, A. C. Gardiner, K. A. Linklater
Inocula derived from two sources of typical border disease (BD) and designated BP-77 and H-77 respectively, were prepared and injected into pregnant ewes of four breeds. The BP-77 inoculum produced higher serum neutralising antibody titres to the cytopathic BD virus than to the NADL strain of bovine virus diarrhoea virus. Only typical BD occurred among the progeny of all four breeds. In contrast H-77 produced higher titres to bovine virus diarrhoea than to BD and typical BD occurred only in the progeny of two of the four breeds. Progeny of the other two breeds appeared normal or had a range of malformations of the central nervous system but none of the characteristic clinical or pathological stigmata of BD. The existence of more than one strain of BD virus is confirmed. Virus strain/host genotype interactions may affect the character of disease in the progeny. The possible implications for diagnosis and control are discussed. It is concluded that the generally accepted criteria for diagnosis of BD are no longer adequate and that the disorder should be redesignated.
The Veterinary Record
https://doi.org/10.1136/vr.104.15.334
Print publication - 14 Apr 1979
10.1136/vr.104.15.334
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Border Disease Medicine & Life Sciences
border disease Agriculture & Biology
Border disease virus Medicine & Life Sciences
breeds Agriculture & Biology
Bovine Viral Diarrhea Viruses Medicine & Life Sciences
bovine viral diarrhea Agriculture & Biology
H 77 Medicine & Life Sciences
alpha-dimethyl-3-tyramine 4 Medicine & Life Sciences
Barlow, R. M., Vantsis, J. T., Gardiner, A. C., & Linklater, K. A. (1979). The definition of border disease: problems for the diagnostician. The Veterinary Record, 104(15), 334-336. https://doi.org/10.1136/vr.104.15.334
Barlow, R. M. ; Vantsis, J. T. ; Gardiner, A. C. ; Linklater, K. A. / The definition of border disease : problems for the diagnostician. In: The Veterinary Record. 1979 ; Vol. 104, No. 15. pp. 334-336.
@article{f808145e10354b7ab1c7aa2e00159e35,
title = "The definition of border disease: problems for the diagnostician.",
abstract = "Inocula derived from two sources of typical border disease (BD) and designated BP-77 and H-77 respectively, were prepared and injected into pregnant ewes of four breeds. The BP-77 inoculum produced higher serum neutralising antibody titres to the cytopathic BD virus than to the NADL strain of bovine virus diarrhoea virus. Only typical BD occurred among the progeny of all four breeds. In contrast H-77 produced higher titres to bovine virus diarrhoea than to BD and typical BD occurred only in the progeny of two of the four breeds. Progeny of the other two breeds appeared normal or had a range of malformations of the central nervous system but none of the characteristic clinical or pathological stigmata of BD. The existence of more than one strain of BD virus is confirmed. Virus strain/host genotype interactions may affect the character of disease in the progeny. The possible implications for diagnosis and control are discussed. It is concluded that the generally accepted criteria for diagnosis of BD are no longer adequate and that the disorder should be redesignated.",
author = "Barlow, {R. M.} and Vantsis, {J. T.} and Gardiner, {A. C.} and Linklater, {K. A.}",
doi = "10.1136/vr.104.15.334",
journal = "Veterinary Record",
publisher = "BMJ Publishing Group",
Barlow, RM, Vantsis, JT, Gardiner, AC & Linklater, KA 1979, 'The definition of border disease: problems for the diagnostician.', The Veterinary Record, vol. 104, no. 15, pp. 334-336. https://doi.org/10.1136/vr.104.15.334
The definition of border disease : problems for the diagnostician. / Barlow, R. M.; Vantsis, J. T.; Gardiner, A. C.; Linklater, K. A.
In: The Veterinary Record, Vol. 104, No. 15, 14.04.1979, p. 334-336.
T1 - The definition of border disease
T2 - problems for the diagnostician.
AU - Barlow, R. M.
AU - Vantsis, J. T.
AU - Gardiner, A. C.
AU - Linklater, K. A.
N2 - Inocula derived from two sources of typical border disease (BD) and designated BP-77 and H-77 respectively, were prepared and injected into pregnant ewes of four breeds. The BP-77 inoculum produced higher serum neutralising antibody titres to the cytopathic BD virus than to the NADL strain of bovine virus diarrhoea virus. Only typical BD occurred among the progeny of all four breeds. In contrast H-77 produced higher titres to bovine virus diarrhoea than to BD and typical BD occurred only in the progeny of two of the four breeds. Progeny of the other two breeds appeared normal or had a range of malformations of the central nervous system but none of the characteristic clinical or pathological stigmata of BD. The existence of more than one strain of BD virus is confirmed. Virus strain/host genotype interactions may affect the character of disease in the progeny. The possible implications for diagnosis and control are discussed. It is concluded that the generally accepted criteria for diagnosis of BD are no longer adequate and that the disorder should be redesignated.
AB - Inocula derived from two sources of typical border disease (BD) and designated BP-77 and H-77 respectively, were prepared and injected into pregnant ewes of four breeds. The BP-77 inoculum produced higher serum neutralising antibody titres to the cytopathic BD virus than to the NADL strain of bovine virus diarrhoea virus. Only typical BD occurred among the progeny of all four breeds. In contrast H-77 produced higher titres to bovine virus diarrhoea than to BD and typical BD occurred only in the progeny of two of the four breeds. Progeny of the other two breeds appeared normal or had a range of malformations of the central nervous system but none of the characteristic clinical or pathological stigmata of BD. The existence of more than one strain of BD virus is confirmed. Virus strain/host genotype interactions may affect the character of disease in the progeny. The possible implications for diagnosis and control are discussed. It is concluded that the generally accepted criteria for diagnosis of BD are no longer adequate and that the disorder should be redesignated.
U2 - 10.1136/vr.104.15.334
DO - 10.1136/vr.104.15.334
JO - Veterinary Record
JF - Veterinary Record
Barlow RM, Vantsis JT, Gardiner AC, Linklater KA. The definition of border disease: problems for the diagnostician. The Veterinary Record. 1979 Apr 14;104(15):334-336. https://doi.org/10.1136/vr.104.15.334