Coumarins scaffolds as COX inhibitors
Hrishikesh Mohan Revankar, Bukhari Syed Nasir Abbas, Gajjela Bharath Kumar, Hua Li Qin
The discovery of COX enzymes has led to a better understanding of inflammation and its related biological pathways. Apart from being related to inflammation and pain, it has also been associated with cancer and neuropsychiatric diseases such as schizophrenia. Proverbially speaking, study of these enzymes has been crucial as they happen to "have fingers in many pies". Non-steroidal anti-inflammatory drugs (NSAID) that act specifically as COX-2 inhibitors have been known for a while; however these are also associated with severe side effects such as cardiac problems. Several heterocylic molecules have been tested for their anti-inflammatory activity specifically as COX-inhibitors. Coumarins also known as benzopyrans are widely found in nature, and are routinely employed as herbal remedies since early days. Over 1300 coumarins have been identified, principally as secondary metabolites in green plants, fungi and bacteria. Recently the use of natural and synthetic coumarins has garnered a lot of attention for their anti-inflammatory activities. In this review we delve further into the study of natural and synthetic coumarins as COX-inhibitors. Although the study is still in its nascent stage, we believe there is scope for a lot of development.
Bioorganic Chemistry
https://doi.org/10.1016/j.bioorg.2017.02.001
Accepted/In press - 3 Dec 2016
Viridiplantae
Benzopyrans
Cyclooxygenase 2 Inhibitors
COX-1 enzymes
Revankar, H. M., Syed Nasir Abbas, B., Kumar, G. B., & Qin, H. L. (Accepted/In press). Coumarins scaffolds as COX inhibitors. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2017.02.001
Coumarins scaffolds as COX inhibitors. / Revankar, Hrishikesh Mohan; Syed Nasir Abbas, Bukhari; Kumar, Gajjela Bharath; Qin, Hua Li.
In: Bioorganic Chemistry, 03.12.2016.
Revankar, HM, Syed Nasir Abbas, B, Kumar, GB & Qin, HL 2016, 'Coumarins scaffolds as COX inhibitors', Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2017.02.001
Revankar HM, Syed Nasir Abbas B, Kumar GB, Qin HL. Coumarins scaffolds as COX inhibitors. Bioorganic Chemistry. 2016 Dec 3. https://doi.org/10.1016/j.bioorg.2017.02.001
Revankar, Hrishikesh Mohan ; Syed Nasir Abbas, Bukhari ; Kumar, Gajjela Bharath ; Qin, Hua Li. / Coumarins scaffolds as COX inhibitors. In: Bioorganic Chemistry. 2016.
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title = "Coumarins scaffolds as COX inhibitors",
abstract = "The discovery of COX enzymes has led to a better understanding of inflammation and its related biological pathways. Apart from being related to inflammation and pain, it has also been associated with cancer and neuropsychiatric diseases such as schizophrenia. Proverbially speaking, study of these enzymes has been crucial as they happen to {"}have fingers in many pies{"}. Non-steroidal anti-inflammatory drugs (NSAID) that act specifically as COX-2 inhibitors have been known for a while; however these are also associated with severe side effects such as cardiac problems. Several heterocylic molecules have been tested for their anti-inflammatory activity specifically as COX-inhibitors. Coumarins also known as benzopyrans are widely found in nature, and are routinely employed as herbal remedies since early days. Over 1300 coumarins have been identified, principally as secondary metabolites in green plants, fungi and bacteria. Recently the use of natural and synthetic coumarins has garnered a lot of attention for their anti-inflammatory activities. In this review we delve further into the study of natural and synthetic coumarins as COX-inhibitors. Although the study is still in its nascent stage, we believe there is scope for a lot of development.",
keywords = "Anti-inflammatory, Coumarins, COX-1 enzymes, COX-2 enzymes, NSAID",
author = "Revankar, {Hrishikesh Mohan} and {Syed Nasir Abbas}, Bukhari and Kumar, {Gajjela Bharath} and Qin, {Hua Li}",
doi = "10.1016/j.bioorg.2017.02.001",
journal = "Bioorganic Chemistry",
T1 - Coumarins scaffolds as COX inhibitors
AU - Revankar, Hrishikesh Mohan
AU - Syed Nasir Abbas, Bukhari
AU - Kumar, Gajjela Bharath
AU - Qin, Hua Li
N2 - The discovery of COX enzymes has led to a better understanding of inflammation and its related biological pathways. Apart from being related to inflammation and pain, it has also been associated with cancer and neuropsychiatric diseases such as schizophrenia. Proverbially speaking, study of these enzymes has been crucial as they happen to "have fingers in many pies". Non-steroidal anti-inflammatory drugs (NSAID) that act specifically as COX-2 inhibitors have been known for a while; however these are also associated with severe side effects such as cardiac problems. Several heterocylic molecules have been tested for their anti-inflammatory activity specifically as COX-inhibitors. Coumarins also known as benzopyrans are widely found in nature, and are routinely employed as herbal remedies since early days. Over 1300 coumarins have been identified, principally as secondary metabolites in green plants, fungi and bacteria. Recently the use of natural and synthetic coumarins has garnered a lot of attention for their anti-inflammatory activities. In this review we delve further into the study of natural and synthetic coumarins as COX-inhibitors. Although the study is still in its nascent stage, we believe there is scope for a lot of development.
AB - The discovery of COX enzymes has led to a better understanding of inflammation and its related biological pathways. Apart from being related to inflammation and pain, it has also been associated with cancer and neuropsychiatric diseases such as schizophrenia. Proverbially speaking, study of these enzymes has been crucial as they happen to "have fingers in many pies". Non-steroidal anti-inflammatory drugs (NSAID) that act specifically as COX-2 inhibitors have been known for a while; however these are also associated with severe side effects such as cardiac problems. Several heterocylic molecules have been tested for their anti-inflammatory activity specifically as COX-inhibitors. Coumarins also known as benzopyrans are widely found in nature, and are routinely employed as herbal remedies since early days. Over 1300 coumarins have been identified, principally as secondary metabolites in green plants, fungi and bacteria. Recently the use of natural and synthetic coumarins has garnered a lot of attention for their anti-inflammatory activities. In this review we delve further into the study of natural and synthetic coumarins as COX-inhibitors. Although the study is still in its nascent stage, we believe there is scope for a lot of development.
KW - Anti-inflammatory
KW - Coumarins
KW - COX-1 enzymes
KW - NSAID
U2 - 10.1016/j.bioorg.2017.02.001
DO - 10.1016/j.bioorg.2017.02.001
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
10.1016/j.bioorg.2017.02.001