Osteomyelitis is an infection of the bone, often developing afteran open fracture in which the bone pokes through the skin. It may also developafter an illness or injury that damaged the skin near or over a bone. Symptoms may include:A general feeling of illnessFever, chills, and sweating. Pain that is worse when pressing on the infected area or whenSwollen and red skin (sometimes) over the affectedDrainage of pus from the wound. Antibiotic treatment is necessary to prevent destruction of bonetissue. If the osteomyelitis is severe, surgery may be required. William H. Blahd, Jr., MD, FACEP - Emergency Medicine & Adam Husney, MD - Family Medicine & David Messenger, MD This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to thehow we develop our content .