H2-antagonists for refluxH2-antagonists were originally introduced for the treatment of peptic ulcers (see H2-antagonists for ulcers). However, due to the high relapse rate of reflux patients taking antacids, maintenance therapy with H2-receptor antagonists (or PPI's) is often indicated. Tolerance can occur and patients chronically using the H2-antagonists may require higher dosages than normal. Famotidine and ranitidine act as anti-ulcer drugs because of antagonism at the parietal cell ofExtra info: Famotidine and rantidine lower gastric pH as they are specific for the H2 receptor.