San Miguel sea lion viral disease (SMSD) within the Caliciviridae family, occurs in sea lions, fur seals, elephant seals, opal-eye fish and several other marine animals. SMSV was first isolated from aborting California sea lions in 1972 by Smith et al. The disease is characterized by fever and oral, as well as extremity, vesicle formation. Infection seldom results in death; however, it is often associated with reproductive failure. Members of the Caliciviridae are small, nonenveloped viruses composed of a single capsid protein. They contain a single, plus-sense, polyadenylated RNA genome.