Bicarbonate loading is a popular ergogenic aid used primarily by athletes in short-duration, high-intensity sporting events and competitions. Controlled experimental trials have shown that small (worthwhile) benefits can obtained from acute doses of bicarbonate taken before exercise. Gastrointestinal problems encountered by some athletes limit the widespread use of this practice, however. The transfer of positive research findings to the competitive environment has proved problematic for some individuals. More recent applications involve serial ingestion of bicarbonate over several days before competition or during high-intensity training sessions over a few weeks. A number of research questions need to be addressed to enhance applications of bicarbonate loading in the elite sport environment. This commentary examines some of research and practical issues of bicarbonate loading used to enhance both training and competitive performance. Burke is with the Dept of Sports Nutrition, and Pyne, the Dept of Physiology, Australian Institute of Sport, Belconnen, ACT 2616 Australia.