What is it used for? How does it work? This medicine contains the active ingredient levocabastine hydrochloride, which is a type of medicine called an antihistamine. It works by preventing the actions of histamine. Histamine is a substance produced by the body as part of its defence mechanisms. It is stored in cells called mast cells, in almost all tissues of the body. When the body reacts to a foreign substance (known as an allergen, eg flower pollen), the mast cells stimulated by the allergen release their stores of histamine. The released histamine then binds to its receptors (H-1 receptors), causing a chain reaction that results in allergic symptoms. It causes an increase in blood flow to the area of the allergy, and the release of other chemicals that add to the allergic response. All this results in the symptoms of an allergic reaction. In nasal allergies such as hayfever, histamine causes inflammation of the membranes in the nose. This results in symptoms such as a runny nose, sneezing and nasal congestion. Levocabastine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area. Levocabastine is used as a nasal spray to allow it to act directly on the membranes in the nose. It blocks the histamine receptors in the nose, which prevents and relieves the typical symptoms of nasal allergies. - This medicine is not to be taken by mouth. - Each container of this medicine should discarded four weeks after the first opening. You may find it helpful to write the date of opening on the pack. Dispose of carefully, preferably by returning to your pharmacy.- Shake the bottle well before use. - This medicine should only be used in children under 12 years of age on the advice of a doctor. It is not recommended for children under nine years of age. Use with caution in- Decreased kidney functionNot to be used in- Significantly decreased kidney functionThis medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Pregnancy and BreastfeedingCertain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. - This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor.- There are no known harmful effects when this medicine is used by breastfeeding mothers. Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. - Irritation of the tissues in the nose- Sleepiness (somnolence) The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist. How can this medicine affect other medicines? There are no significant interactions reported with this medicine. However, if you are using this nasal spray in combination with levocabastine eye drops or an oral antihistamine it is possible that this could make you feel drowsy. If affected you should take care when driving or operating machinary. Other medicines containing the same active ingredient|Livostin nasal spray (discontinued in the UK)|