###Human: I have burning irritation in the middle portion of the penis after masturbation. Please help. ###Assistant: Hi. Penile pain occurs due to infections or inflammation of the bladder or prostate. Trauma, persistent erection (priapism), cancers, and Peyronie's disease (the development of scar tissue within the penis) are the other causes. Sickle cell anemia may cause priapism due to blockage of small blood vessels in the penis. I suggest you consult a doctor for a physical investigation.