###Human: What is Lyme disease? Will it cause joint pain and depression? ###Assistant: Hi. I assure you not to worry at all as things may get settled with proper care and follow-up. Yes, depression and the joint disease may definitely be associated with the untreated Lyme disease.  There are a lot of things that need to be cleared right away in history. I have written just for you to alleviate your concerns, once for all. Do answer where I ask a question, send back in follow up along with all the laboratory results you just went through.  There are three main stages of the Lyme disease.  Stage 1: This is 1-30 days after the tick bite. It comprises the vague febrile illness with a typical red rash named Erythema migrans (the rash that appears usually in unseen areas like axillae, groin and the back of the knee areas, almost after a week of the tick bite).  I wish to know, 1. Did you get this rash sometime? 2. If yes, can you please give me details as when? 3. Any eye redness, tearing, neck stiffness at that time with mild fever, etc?  Stage 2: Early disseminated disease which is 3-10 weeks after the tick bite. It includes fever and malaise, eye and vision problems, heart issues, joint pains mostly knees, ankles, wrist involvement.  There are also the neurological manifestations like meningitis, facial palsy, headache, neck pain or stiffness, photophobia. Also memory problems, mood changes, sleep and personality changes, depression etc., with some skin rash.  STAGE 3; Months to years after the initial infection which is latent or chronic Lyme disease, I have seen my patients get a latency period with no disease and again erupted with stage 3 after sometime.  Facial palsy and joint pains are very important and common manifestation of the late disease. Bladder dysfunction, hearing loss, cognitive impairment, other neurological manifestations including depression are common. Treatment plan can be decided on seeing the blood work in follow up along with the details in history.