###Human: I got an itchy rash on anus with no anal sex. Could it be HPV? ###Assistant: Hi. I have seen the picture. (attachment removed to protect patient identity).  There is definitely an inflamed swelling in that area. Central area is white. As you are having a lot of hairs, that area can easily get infected. Are you having any fissure problem? Please check your blood sugar. It is not HPV (human papillomavirus). Warts will be presenting as asymptomatic growth, so it is not herpes also. It is furunculosis (bacterial infection of the hair follicle). Please start on antibiotics Doxycycline 100 mg twice a day for one week. Apply Mupirocin ointment in that area. Drink lots of water. See that you are not having constipation. Wash the area with water and soap after defecation. After the Corona crisis meet your doctor. I hope this helps.