###Human: My sister's report shows 46, XY chromosome. What does this mean? ###Assistant: Hi. How are you doing? This is a tough condition to explain, but let me try. 46 chromosomes mean the total number of chromosomes is normal. For a normal female, the sex chromosome should be "XX". "XY" means male. So, your sibling who is looking as or phenotypically female is actually or genotypically a male. This is mostly androgen insensitivity syndrome, where genetically she is male, but her body tissues are not sensitive to the male or androgen hormone so that he will appear as female. All of us are born as females in mother's womb, but which hormones we are exposed to, based on the genes, we get converted to male or stay as female. But in your sibling, the gene is a male, but his body receptors for this male hormones is not effective, so will continue to be female. For further queries consult an obstetrician and gynaecologist online -->