###Human: Can nicotine in vape worsen OCD? ###Assistant: Hello. Nicotine smoke could increase the stress and might make OCD (obsessive-compulsive disorder) symptoms worse. You have to stop this. You are on Chlorpromazine for mood and psychotic symptoms but there is no specific drug to control anxiety and obsessive thoughts. Drugs like Fluoxetine should be added to your prescription in order to improve the OCD symptoms and anxiety. A low dose can be used safely in bipolar disorder too. Please talk to your psychiatrist about this.