###Human: Kindly suggest me long term drugs without side effect for anxiety and depression. ###Assistant: Hello. You should go with Escitalopram (Escitalopram Oxalate), Clonazepam and Mirtaz (Mirtazapine). These combinations have a minimal side effect. You take antacid with it. Please do not take the above medications in an empty stomach. You must lose your weight. Do the daily exercise for 30 to 45 minutes and practice meditation for 10 to 20 minutes daily. Avoid junk foods, eat healthy home-cooked meal. Stop alcohol, smoking tobacco or stay away from any type of substance abuse. Spend quality time with friends and family. Spend time for your creative hobbies like read good books, write journals, do paintings, learn new skills or music, etc. Take enough seven to eight hours of sleep. Take a cold shower. Drink three liters of water daily. Live your life, do not just spend. Go for a vacation, spend time with nature. Stay away from social media as much as you can. Prothiaden (Dosulepin) will cause constipation. And low energy can be due to depression or anemia or thyroid abnormalities. It is less likely due to medication. Toficalm (Tofisopam) and Prothiaden will cause you oversedation or make you drowsy the next day.