###Human: Kindly advise the treatment for severe constipation. ###Assistant: Hi. You seem to be suffering from an acid peptic disease associated with functional constipation. I would recommend you the following: 1. A combination of Pantoprazole and Levosulpride once daily. This would help you with bloating and reduce gurgling sounds. 2. To take syrup Lactulose 20 ml in the night. 3. To take smooth muscle relaxants like Mebeverine. Another important aspect is that have you got your thyroid profile done?