###Human: I am having terrible acne issues since my teenage. Can I take Isotretinoin? ###Assistant: Hello. I have reviewed the images (attachment removed to protect patient identity) Moderately severe to severe grade of acne and persisting since years such as in your case is an automatic choice for treatment with Oral Retinoids i.e Isotretinoin. You may continue with other topical medications like Adapalene, Clindamycin, and Benzoyl peroxide gel and oral antibiotics such as Azithromycin.