###Human: How much time does it take for Acidophilus to get out of the system? ###Assistant: Hi. I do not think your indigestion is because of Acidophilus. Also, these probiotics do not get into the system. It just stays in the GI tract. They do not get absorbed. They can stay for a longer period of time and are beneficial. I think all this indigestion-like feeling is dyspepsia, may be non-specific. Just avoid overeating, spicy, and oily food. You can use Nexum 40 mg tablets over the counter for 1 to 2 weeks, every day in the morning 20 minutes before breakfast. You will get better.