###Human: What is the risk of Down's in my wife's double marker report? ###Assistant: Hello. To explain you the report in plain language, first of all, let me tell you that the dual marker test is just a screening test for Down's syndrome and other chromosomal anomalies like trisomy 13/18. So, the test involves calculation of the risk of carrying a Down's syndrome baby by the mother, which is then compared with the general population's risk. In your case, although the risk based on serum markers is high, the combined risk taking into account the age, NT, and the markers is still below the cut-off. So, it means it is a low risk. For more information consult an obstetrician and gynaecologist online -->