###Human: I have severe leg cramps at night. What is causing this? ###Assistant: Hi. The causes for these kinds of muscular cramps are not quite clear. It is believed to be associated with chemical imbalance within the muscle cells. Some of the conditions causing these cramps are: No drug is specifically proven to cure these muscle cramps. Once the underlying condition gets corrected, nocturnal cramps usually subside. I suggest you check your blood sugar, complete hemogram and serum electrolytes (calcium, potassium, magnesium). Also check your thyroid status with TSH to assess the effectiveness of your current thyroid medication. We need to rule out a rare possibility named DVT (Deep Vein Thrombosis) with physical examination and if needed color doppler study of your lower limb blood vessels and then proceed with the necessary treatment.I would also suggest you follow the below suggestions to get relief in the meantime. Revert back with the reports to a general practitioner online -->