###Human: What is causing decreasing platelet count after a fever episode? ###Assistant: Hello. Normally, you have anywhere from 150,000 to 450,000 platelets per microliter of circulating blood. Platelets are produced in your bone marrow. Factors that can decrease platelet production include some types of anemia, viral infections, chemotherapy drugs, heavy alcohol consumption, dangerous internal bleeding can occur when your platelet count falls below 10,000 platelets. Nothing to get fear unless you do develop a complication bleeding, most often from the gums or nose. Red, flat spots on your skin, about the size of a pinhead.