###Human: My younger brother is about to get married. His sperm count is nil. Please help. ###Assistant: Hello. First of all, I would like to tell you that biopsy is completely safe. It hurts very minimally, only like an intravenous injection. During a biopsy, a small piece of tissue (from the testis) is taken for examination and there is no risk of damaging his testis forever. The biopsy of the testis is one of the options out of many tests which have to be done before complete diagnosis. Nil production of semen is more likely due to blockage of ejaculatory duct. Before going for biopsy of the testis, he should go for checking the patency of ejaculatory duct. If they have already checked this in the tests which were conducted earlier, then he can go for the biopsy.  Consult a urologist online for further clarifications -->