###Human: In nephrotic syndrome, protein leaks from the larger filter of kidney. Is it true? ###Assistant: Hi. Yes, you have heard the things right. Due to increased pore there is protein in urine. The best treatment remains the Cortisone. In cases where there is no response to Cortisone as evidenced by persistence of albumin in urine, we need to shift those patients on Cyclophosphamide and Azathioprine. Renal biopsy can be performed but since you are on steroids the reports may be altered. You need to get C3 (complement component 3), C4 (complement component 4), ANA (antinuclear antibody), ANCA (antineutrophil cytoplasmic antibody) and urine protein to creatinine ratio.