###Human: I get shortness of breath and chest tightness after taking Hydroxychloroquine for fever. Why? ###Assistant: Hello,  Welcome to icliniq.com. I can understand your concern. According to your statement, you have been suffering from shortness of breath, chest tightness without any cough, and cold. Shortness of breath, chest tightness can result from some conditions which are mentioned below. Anxiety is a common condition associated with chest tightness, shortness of breath, rapid heart rate, sweating, nausea, etc. GERD (gastroesophageal reflux disease) occurs when stomach acid travels back up from the stomach to the esophagus and associated with chest tightness, shortness of breath, difficulty swallowing, etc. Muscle strain typically occurs from intense activities like reaching or lifting when twisting related with the same clinical features. Costochondritis is the inflammation of the cartilage in the rib and associated with the same type of features. Even PUD (peptic ulcer disease), valvular heart diseases, pulmonary HTN (hypertension), esophageal rupture, pericarditis, hiatus hernia, etc can cause chest tightness with shortness of breath. Treatment depends on the causes. So you should undergo ETT (exercise tolerance testing), echo, endoscopy of upper GIT (gastrointestinal tract), barium swallow test, CBC (complete blood count), etc for detection of underlying causes which are responsible for your sufferings. You should also undergo FEV1 (forced expiratory volume), ABG (arterial blood gas) analysis, spirometry for pulmonary function test, reversibility test, etc for the diagnosis of bronchial asthma as your pulmonologist has diagnosed earlier according to your prescription. (attachment removed to protect patient identity).