###Human: Had a bypass surgery. Can I take Actifed and Otrivine nasal drops together? ###Assistant: Hi. I would suggest it is better to space these out at least two hours apart. Give a gap of two hours before taking other after taking one. Pseudoephedrine and Oxymetazoline have common alpha agonist activity, can increase, give a surge in BP, especially if your BP already remains at the borderline. Another thing that I am concerned is, if you have underlying subclinical BPH, taking these two together can precipitate urinary retention and you will not be able to empty bladder.