###Human: When should I opt for 5-HTP after the withdrawal of Pristiq? ###Assistant: Hello. As you are tapering your Pristiq (Desvenlafaxine), there will be no withdrawal at all. You need to restart because of anxiety or depression disorder, not because of withdrawal. 5-HTP (Hydroxytryptophan) is not FDA approved and no guideline for it to how to use and when to use. It is a supplement product, but not a medication to treat. You should follow depression and nonpharmacological management. Do exercises daily for 30 to 45 minutes like walking and practice meditation for 20 minutes daily. Eat healthy home cooked foods, avoid junk foods. Spend quality time with friends and family every day. Spend time for creative hobbies like reading good books, writing journals, painting, drawings, and learning new skills or language or musical instruments. Have enough of 7 to 8 hours of sleep daily. Avoid tobacco or alcohol or any substance abuse. Live your life, do not just spend it. Be bold and confident.