###Human: My D-dimer is raised from 1. 5 to 5. 9 and all tests are normal. What could be the reason? ###Assistant: Hello. Following is my opinion about your asked question. D-dimer is usually elevated in some thrombotic events in the body like DIC (disseminated intravascular coagulation), deep vein thrombosis or pulmonary embolism. But your CT chest and Doppler leg are normal as per history. So pulmonary embolism and DVT can be excluded. The other causes for elevated D-dimer can be liver disease, heart disease, inflammation, post-surgery, and pregnancy as well. Your heart is normal as per history, so heart disease can be excluded. You can rule out the liver disease by SGPT (serum glutamic pyruvic transaminase), SGOT (serum glutamic-oxaloacetic transaminase), and serum protein estimation. If you have pregnancy or surgery history than it can be the cause. PT (prothrombin time), PTT (partial thromboplastin time) and coagulation profile can be planned by your doctor if D- dimer remains persistently high. Kindly attach your report to give further comments if possible.