###Human: From the MRI report, what is your opinion regarding the heaviness of head? ###Assistant: Hello. I understand your concern and would explain that your mother's symptoms seem to be related to depression with psychotic signs. The lesions in MRI are suggestive of small vessel disease. I would recommend taking daily baby Aspirin 80 mg to help the progression of these changes. In my opinion, her current therapy is quite complicated, and many interactions between drugs can worsen her situation. I would recommend stopping Mirnite (Mirtazapine) and Sertee (Sertraline) because they both interact with Ventab XL (Venlafaxine). Increasing the dose of Ventab XL may be necessary. Treatment of depression will help reduce the headache. You should discuss with her psychiatrist on the above treatment option.