###Human: Is it safe to switch to Wellbutrin while on Cymbalta? ###Assistant: Hi. Thank you for taking help from a psychiatrist. You can take Cymbalta and Seroquel. You are already on both medications, so you should continue both medications. If you fill depressed then take tablet Wellbutrin 150 mg once in the morning for a short period of time, then we can taper off within 6 months. If you do not improve your depression on 150 mg of dose after 15 days then we can increase the dosage as per requirement. You can take medications together and you do not need to space out. But you must take Seroquel at night as it causes sedation. Even you should follow some non-pharmacological management as mentioned below. 1. Do exercises daily for 30-45 minutes like walking. 2. Do meditation for 20 minutes daily. 3. Eat healthy home cooked foods, avoid junk foods. 4. Spend quality time with friends and family daily. 5. Spend time for creative hobbies like read good books, write journals, painting, drawings, learn new skills or language or musical instruments. 6. Take enough (7-8 hours) sleep daily. 7. Avoid tobacco or alcohol or any substance abuse. I hope this helps.