###Human: My father is a cardiac patient and under Sintrom. Can he take nystatin? ###Assistant: Hello, I passed carefully through your concern and would like to explain that Sintrom (Acenocoumarol) Nystatin do not show any adverse interaction when taken in the same patient concomitantly. Nystatin taken orally has poor intestinal absorption and could not reach the circulating blood in sufficient amount potentially interact and produce adverse effects. No cardiac issues will arise from that. I hope to have clarified your concern.