###Human: I am having numbness in legs and arms after taking Nortriptyline. Why? ###Assistant: Hello. I read carefully your question and would explain that the complaints that you describe, are not common adverse effects related to Amitriptyline or Nortriptyline. I do not find anything really concerning in your symptoms, besides the fact that these drugs do not seem to be effective in controlling your headaches. Coming to this point, I would first recommend performing a brain CT scan or MRI in order to be sure that it is a primary headache. Some blood laboratory tests are also necessary. Considering the numbness in your limbs, get complete blood count for anemia, thyroid hormone levels for thyroid dysfunction, PCR, ESR for inflammation, blood electrolytes for possible imbalances. You should discuss with your doctor on the above tests, before switching to another drug. In the meantime, it is fine to gradually stop Nortriptyline.