###Human: Nose bleeding-what could be the major cause? ###Assistant: Hi. From the medical history of your child, I can understand that she is having bleeding manifestations with normal CBC (complete blood count) and coagulation workup. I would like to know about the below-mentioned questions, The most common bleeding disorder is a condition known as Von Willebrand disease. I think she needs to be checked for it and the other condition which needs to be evaluated is platelet dysfunction. Investigations suggested are,