###Human: Is it normal to have knee pain after running on a treadmill? ###Assistant: Hello. The pain what you described could be due to an iliotibial band (ITB) friction caused due to tight gluteus muscles. Because of running, no proper warming up or fatigue. Please do not worry, it is a commonly encountered situation in runners and is completely solvable. I would recommend you to do icing frequently over the painful area. Stretch your gluteus, calf, and hamstrings. Roll an iced bottle over the outer side of your thigh and over the butt, the outer part of your hamstrings, and calf. Kindly revert back after two days to let me know the status of the pain. Do proper warming up before running. Good footwear will help to reduce such issues.