###Human: I need a second opinion for the medicines I take for bipolar I and ADHD. ###Assistant: Hello. The rule of thumb in psychiatry is to prescribe medicine for an adequate duration and adequate dose, before considering it ineffective or plan to change. If your doctor has previously tried one medication for proper dose and duration now, he can add another drug, so it depends on how you are responding to medicine? So it might be possible that if you did not respond to one medicine your doctor keeps adding medicine to your prescription. If you are not in a depression or not a rapid cycler, Sertraline can be tapered down. If you are in remission, Lamotrigine can be slowly stopped. I found no counteracting drug. Antidepressants can be given with mood stabilizers in bipolar disorder (depression episode).