###Human: Can Trintellix cause lump in throat? ###Assistant: Hi. Trintellix is a type of selective Serotonin reuptake inhibitor which work by increasing serotonin levels in blood. The serotonin further treats the anxiety and panic attacks but sometimes SSRI may cause activation like rapid increase of serotonin in blood, which may lead to temporary increase in anxiety. To solve the issue, you can start with half tablet, a dose of 2.5 mg for initial five days, then make it 5 mg and continue it further. If it also does not help you, then contact your psychiatrist.