###Human: My daughter's cough got worse after taking Prednisone. Why? ###Assistant: Hi. It is less likely to be a viral infection as the temperature is quite high. It may be a viral bug, and it can be worsened after the administration of the steroid. Do not give steroid without a prescription to the child. Do a respiratory PCR, and it helps to find the exact cause of the same. A cough may have worsened following the steroid probably, because, it can be an infectious disease to be treated by antibiotics. It may not be a drug reaction to the steroid, but possibly an overdose. Children do vomit multiple times with a high oral dose of steroids.