###Human: I have a strong history of cancer. Should I concern about the sore in my leg? ###Assistant: Hello. I have gone through your case. In my opinion, your lesion should be biopsied as early as possible as you have a long-standing history of cutaneous cancer, and I fear it could be slow-growing skin cancer. I have two to three differential diagnosis. 1. Nodular squamous cell carcinoma. 2. Nodular non melanocytic melanoma. 3. Basal cell carcinoma. 4. Keratoacanthoma. 1.Sun-exposed area. 2.White race and, 3 Past history of cancer Biopsy. Need excision as early as possible.