###Human: My alpha 2 globulin and gamma globulin are high. What does this mean? ###Assistant: Hello. You have not mentioned which autoimmune disease test has come positive. High levels of alpha 2 globulin are seen when there is a loss of albumin via urine because alpha 2 is a large molecule. It does not pass kidney filtration. So, it is retained because it is a component of globulin. That is the reason for high levels of globulin in blood. You need to test your 24-hour urinary protein that will tell whether you are losing protein in urine or not. Regards. For more information consult a rheumatologist online -->