###Human: My granddaughter is 2 months old with persistent jaundice. Please review her reports. ###Assistant: Hi. Persistence of direct bilirubin at two months of age needs to be evaluated properly. Most importantly, what is the color of her stool? Is your doctor told you anything about the liver whether it is big or normal? There are so many causes, but most important and serious and need timely intervention is extrahepatic biliary atresia which as per information has been ruled out. Other common causes can be neonatal hepatitis or some metabolic disorder. The list of causes is long so better if you can share all the reports (blood, urine, sonography, Torch titer, TFT, enzymes, alpha 1 anti-trypsin, etc), I can advise you on how to proceed further and whether it needs further investigations.