###Human: My mother is having mutiple myeloma. Will allogeneic transplantation help her? ###Assistant: Hi. The advantage of allogeneic stem cell transplant is that the donor stem cells make their own immune cells. They help to destroy the cancer cells that remain after high-dose treatment. It is called as a graft-versus-cancer effect. Autologous stem cell transplant does not offer the benefits of graft versus tumor (GVL) effect when healthy donor cells attack cancer cells, and they do not carry the risk of transplantation rejection due to graft versus host reaction. They are relatively safe procedures, with low rates of complications and infections compared with allogeneic transplants. Deaths due to the transplant are approximately 2 % to 3 % in patients with newly diagnosed myeloma. In theory, one disadvantage of autologous stem cell transplant is that the transplant can potentially get contaminated with tumor cells when patient stem cells are used. However, recent studies indicate that this is not a significant problem and it is not a significant cause of myeloma relapse.