###Human: Am I having bladder irritation or tightening because of Lisdexamfetamine? ###Assistant: Hi. If you are having increased frequency of urination, night-time frequency, the urgency of urination, it may be an overactive bladder. It can occur spontaneously or be precipitated by UTI episodes, stone disease, medications, etc. In your case, the medicine may not be responsible. But anyway, we cannot change the medicine. You need to restrict your fluid intake to about 2 to 2.5 liters per day, limit intake of carbonated beverages, coke, tea, coffee. You have to avoid constipation. You may also get a urine test done for sugar to rule out diabetes. If frequency persists, you may take an anticholinergic like Tolterodine or Darifenacin after consulting your doctor. Take care.