###Human: Can missed period after having sex during fertile period mean pregnancy? ###Assistant: Hi. Since you have been actively trying to conceive and having unprotected sexual intercourse on fertile days does put the possibility of pregnancy high up on the list especially coupled with a missed period. A home pregnancy test can be negative in the first few days after the missed period even in case of successful fertilization owing to insufficient beta hCG hormones. I suggest you take another urine strip test after a week if you still do not get your periods. Or could get a blood test for serum beta hCG in a few days which is more sensitive. In any case, you should treat it as a possible pregnancy unless proven otherwise and take your vitamins.