###Human: I have large intestine obstruction with constipation and piles. Please suggest medication. ###Assistant: Hello. I have reviewed your situation. For confirmation, what is going on, you need to visit to a gastroenterologist and get booked for upper and lower GI (gastrointestinal) endoscopy. But reading at your situation, it looks you have both acidity problem and constipation. Till you meet some gastroenterologist, you can take capsule Nexium 40 mg (Esomeprazole) once a day before meal, and Isphagol husk two teaspoons in a glass of water, keep it for four hours and then take it. If you still feel symptoms, you can follow us. So we can upgrade the treatment. I hope this helps.