###Human: Will sleep deprivation cause any permanent changes in brain? ###Assistant: Hi. Yes, the research has gained a lot of attention and we do consider the facts. But, what has been done cannot be reversed. However, if we go with clinical experience, usually people who modify back there lifestyle do not get any ill effects in life. In fact, I would advice in such case that you should stop thinking that what is reversible and what is not. Start living your life normally and take help with a psychiatrist if there is great difficulty in sleeping. One can be treated easily with hypnotic drugs which help in controlling these issues.