###Human: How can I treat allergic reaction to Doxycycline? ###Assistant: Hi. The presented photograph is not hives (attachment removed to protect patient identity). It is chronic dermatitis. It has nothing to do with Doxycycline. You need a medium potency Corticosteroid cream like Betamethasone valerate 1 % twice daily for two weeks with an anti-allergic tablet like Loratidine 10 mg once daily for 10 days. Hives are different. They appear reddish and appear and disappear. In that case, you need same anti-allergic tablet mentioned above plus Calamine lotion. If it is severe, you need to see a GP. It requires injectable medications.