###Human: Can mixed spongiform thyroid nodules be malignant ? ###Assistant: Hello. I just read your query and from what you have mentioned it appears that you have a thyroid nodule. According to the guidelines, if the nodule is more than 75 % of spongiform appearance, then they are benign and if less than 75% then there is a chance of malignancy which must be confirmed by FNAC (fine needle aspiration cytology). In your ultrasound, there is no percentage depiction of the spongiform portion. Secondly, the malignant nodule has hypoechogenicity and microcalcifications which is present in your report. Please, it is my advice to you to not come to any conclusion before an FNAC. For more information consult an endocrinologist online -->