###Human: Can reducing the dose of Dexamethasone cause liver problem? ###Assistant: Hi. I would like to know a few things very clear here. From your history, I gather that he had surgery on the brain and was on steroids post-op. And also he received radiotherapy. For what condition the brain surgery was done? He might be having what is called as steroid-induced diabetes and for which Insulin is the treatment. Steroids can harm the liverover time, but they would have been prescribed because the benefit at that time was more than the harm that would have been caused. We need to know the clinical improvement with reduced dose for further reduction. There are no medicines that can restore the adrenal cortex function. His steroid production is suppressed due to exogenous steroids. It needs tapering and then if possible can be stopped. I can comment on his recovery only after knowing his exact detail of the medical procedure done and the diagnosis.