###Human: Can fibroadenoma with cyst BI-RADS 2 to 3 lead to cancer? ###Assistant: Hello. Based on the report (attachment removed to protect patient identity), fibrocystic disease of breast and fibroid uterus, both of them are due to hormones, mainly estrogen. When using Sevista (Ormeloxifene), the fibroid in the uterus will decrease. For breast condition, BI-RAD 2 to 3 means it is was a benign (it can regress) condition (not cancer). Treatment depends on menopause. If she has not attained menopause, then she has to use Sevista. If she has attained menopause, after some time, Sevista can be stopped. With menopause, the fibroid can disappear. Fibrocyst of the breast may persist, but malignancy is very rare. At present, no need to worry. Frequent six months or yearly once monitoring with ultrasound is enough. Further treatment depends on whether she had excessive bleeding (menstruation), her calcium levels, family history of breast or other cancer. For more information consult an internal medicine physician online -->