###Human: Small hole in the heart closed by 18 months of age. Is there any chance of future health problem? ###Assistant: Hi. It is less likely that a hole that has closed will open again. Hence as regards to the hole in the heart you need not worry if it has closed. A repeat 2D Echocardiogram would be advisable to see the exact status of the hole (if not done) to detect for any other anomalies and prospects regarding the heart.