###Human: Is Imipramine recommended for anxiety and panic disorder? ###Assistant: Hello. I can understand your problem. Imipramine is a tricyclic antidepressant drug, and yes the drug is known to result in side effects like weight gain. But this depends upon the dose, the duration of treatment, patient factors, etc. Lexapro (Escitalopram), Wellbutrin (Bupropion), Effexor (Venlafaxine), Prozac (Fluoxetine), etc., are serotonergic drugs and it is common with these drugs to see increased anxiety for first few days of starting the drugs. In most cases, this rebound increase in anxiety goes by own. So my advice is to continue the drugs even if you see worsening of symptoms. In most cases, after a week of starting the drugs symptoms remit. Imipramine is also the right choice, and the drug causes sedation so you should take medicine in the evening after dinner and should start with low doses. When the drug is started in low doses, then you will not face any rebound increase in anxiety. Kindly get ECG done before starting the medication.