###Human: Is factor V Leiden mutation related to any health issues? ###Assistant: Hello. Protein S deficiency causes an increased risk of developing blood clotting disorders mainly thrombosis. It can be hereditary or acquired. Acquired protein S deficiency is seen in liver disease or vitamin K deficiency. Your daughter is heterozygous for factor V Leiden mutation which further increases the risk of thrombosis and developing clots. It is advisable that you consult with a hematologist to determine if she might require any monitoring or prophylaxis. For more information consult a hematologist online -->