###Human: What is the treatment for soreness in penile shaft? ###Assistant: Hello Welcome to icliniq.com. Usually, whenever soreness is present over the penis we have to rule out herpes or syphilis. But I have seen attached image (attachment removed to protect patient identity). It does not look like any sexually transmitted illness. For a few days, it is advisable to stop masturbation and you can apply topical antibiotic cream over that. If no improvement, then you have to consult a dermatologist for detailed evaluation.