###Human: There is enlarged liver in anemic and hypothyroidism patient. Is it serious? ###Assistant: Hi. I have reviewed the ultrasound report (attachment removed to protect patient identity) and I can say that she has hepatosplenomegaly probably due to fatty liver disease. This is why to my opinion she needs to do liver enzyme tests like AST, ALT, GGT and alkaline phosphatase, blood work too. It is important to lose weight and to avoid fatty foods.