###Human: What can be done to cure joint pain with muscle tenderness? ###Assistant: Hi. I would like to ask you a few more queries:  1. Is your sleep pattern fine? Morning fatigue?  2. How frequently are you taking Diclofenac?  3. Any hair fall/oral ulcers/dry eyes/dry mouth?  4. Any recent irritability or forgetfulness?  5. How much was the level of CRP you had mentioned?  6. A personal question: But is there a particular reason for the depression? Any family history for endogenous depression?  There can be many reasons of pain. We need to distinguish if it is inflammatory or non inflammatory. Alone ANA positive may not imply much here. We have to see if it is impacting your system as well.