###Human: Please guide me about PNP immunodeficiency disease. ###Assistant: Hello. PNP deficiency is a very rare condition, in which the body is unable to produce certain immunity related cells called T cells, this happens due to some gene defects and is usually inherited. (But parents might not be affected). This causes the child to get frequent infections involving different body organs, especially the brain, lungs, etc., causing much sickness. Child would be prone to unusual infections also, as the body mechanism to take care of infection is not complete. Till today, the only curative option is hematopoietic stem cell transplant, which carries the risk of failure and side effects. Otherwise, the condition is life-threatening, and children might succumb in the first or second decades of life. He is being treated for his brain infection and its complications, presently. I am afraid the disease has little treatment options and is mostly symptomatic. Genetic.