###Human: Is it safe to have Ashwagandha along with Effexor and Trazodone? ###Assistant: Hello. Effexor (Venlafaxine) and Trazodone are good drugs for depression and anxiety but will have some side effects. You may take Ashwagandha 600 mg (morning and night), Centella Asiatica (morning and night) as a supportive therapy. There must be one hour gap between modern drugs and herbal supplements, to prevent their interactions. Consuming Ashwagandha and Centella Asiatica is safe. On a long term basis, it will reduce the side effects of modern tablets and also stabilize the nervous system functions.