###Human: Is it right to have chemotherapy for stage IV invasive lobular carcinoma? ###Assistant: Hi. I have gone through the attachment (attachment removed to protect patient identity). Yes, it is appropriate to use chemotherapy at this juncture. The HER2 (human epidermal growth factor receptor 2) result is mentioned as equivocal. So please do a FISH test (fluorescence in-situ hybridization) to find out whether it is positive or negative. After chemotherapy, consider doing a maintenance hormonal therapy. Immunotherapy in breast cancer is still in infancy, and promising results are seen in triple negative breast cancer women. I will not suggest a clinical trial at this juncture.