###Human: I am in testosterone replacement therapy and my PSA got increased. Please advice. ###Assistant: Hi. The absolute PSA (prostate-specific antigen) level is in the range where it is not of much concern. But the rise in PSA is bothersome if it rises more than 0.75 ng/mL per year. For a young patient like you, even this rise in rate needs to be assessed. Testosterone replacement can also be a cause of this rise. Please mention about the reason for taking testosterone replacement therapy.