###Human: I have done hemoglobin variant analysis. Please let me know what does it indicate. ###Assistant: Hi. Based on your query and attached reports, my opinion is as follows: (attachment removed to protect patient identity) Increased HbS with reduced HbA at this age suggests possible sickle cell trait disease. Most important evaluation is the possibility of the transfer of this to the next generation, to your kids. Hence, evaluation is necessary. As a complete workup has been done, no anomaly is detected and there is no organ damage at present. Nutritional anemia is additionally present. Iron supplements, vitamin B12, and folic acid supplements are necessary. Anemia correction is necessary. If there are any complications in future, hydroxyurea therapy may need to be started. Vaccination against Streptococcus pneumoniae, Haemophilus influenzae, and hepatitis B is necessary.