###Human: What is the reason for having an increased liquefaction time in semen analysis? ###Assistant: Hi. The most common cause for having an increased liquefaction time are infection or dehydration. It usually takes less than 20 minutes for the semen to change from a thick gel to a liquid. Having a long liquefaction time may indicate an infection. So you may require a course of antibiotics and repeat sampling after three days for reassessment.