###Human: What is the reason for itching between thighs and genital organ? ###Assistant: Hello. I have gone through your query and I have noted your concern. You seem to have a fungal infection, that is tinea cruris. I suggest oral Fluconazole 150 mg tablet, once a week for four weeks. Topically, you may use Luliconazole 1 % cream, twice daily. I also suggest you take a tablet of Cetirizine for symptomatic relief from itching.