The article discusses the role of cAMP in multi-cellular eukaryotic organisms and how it is transduced by two intracellular receptors, PKA and EPAC. Both receptors are activated by increased cAMP levels and are expressed in all tissues, making it important to dissect their individual roles in various models. However, there are currently no EPAC-specific antagonists or agonists, making it a challenge to determine the physiological functions of EPAC. The research may lead to new therapeutic strategies for conditions such as diabetes, heart disease, and cancer. Is the molecule effective to this assay?