The article discusses the need for novel approaches to combat malaria due to the lack of a vaccine and resistance to current drugs. The interaction between two essential parasite proteins, AMA1 and RON2, is crucial for invasion and offers a promising target for drug design. A high throughput screening assay using AlphScreen technology was developed to identify small molecule inhibitors of this interaction. However, due to limitations of the assay, a counterscreen was necessary to identify true inhibitors and weed out false positives. Is the molecule effective to this assay?