The article proposes using human tyrosyl-DNA phosphodiesterase 1 (TDP1) as a new target for anticancer drug development. They plan to directly identify novel TDP1 inhibitors that are active in a cellular environment by screening small molecules on Tdp1-/-;hTDP1 cells exposed to camptothecin. The hit compounds will be evaluated in Tdp1-/- cells and biochemical gel-based assays will be used to assess whether they specifically target TDP1. Is the molecule effective to this assay?