The assay aims to identify small molecule inhibitors for the Vpr protein in HIV-1, which plays multiple roles in the viral life cycle and contributes to the pathogenesis of AIDS. The fission yeast model system will measure cell death induced by Vpr and be used to screen the NIH Molecular Libraries Small Molecule Repository for potential inhibitors. The goal is to provide a new approach to reduce Vpr-mediated detrimental effects in HIV-infected patients and prolong their lives since there are currently no anti-Vpr drugs available. Is the molecule effective to this assay?