COc1cc(/C=C2\N=C(c3ccccc3)N(C3Nc4cc5c(cc4S3)NC(N3C(=O)/C(=C/c4cc(OC)c(OC)c(OC)c4)N=C3c3ccccc3)S5)C2=O)cc(OC)c1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?