O=C1[C@H]2ON=C(c3ccc(F)cc3)[C@H]2C(=O)N1Cc1ccccc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?