COc1cccc(C(c2nnnn2C2CCCC2)N2CCC3(CC2)C(=O)NCN3c2ccccc2)c1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?