COC(=O)/C=C/c1ccc2c(c1)CC1(C2)Cc2cc3c(cc2C1=O)CCC3
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?