COc1cc2[nH]c3c(c2cc1OC)CCN[C@@]31CC[C@@]2(CC3c4c(cc(OC)c(O)c42)CCN3C)C[C@@H]1OC
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?