COc1cccc(CN(C)CC(=O)Nc2cc(S(=O)(=O)N3CCCC3)ccc2Cl)c1OC
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?