COc1ccccc1-c1cc(NC(C)=O)c2ncc(-c3cccc(C(F)(F)F)c3)n2c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?