COc1ccc2c(c1)[C@H]1[C@H](CO2)[C@H](c2ccccc2)[C@@]2(C)C(=O)N[C@H](C)C(=O)N12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?