COc1cc(/C=C/C2=NN(c3cccc(S(=O)(=O)O)c3)C3(C2)SCC(=O)N3c2nc3ccccc3s2)cc(OC)c1OC
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?