COc1ccc2c(c1)OC[C@H]1[C@H]2N2C(=O)c3ccccc3NC(=O)[C@@]2(C)[C@H]1c1ccccc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?