Cc1cccc(-n2c(CC3C(=O)Nc4ccc(C)cc43)nc3ccccc3c2=O)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?