O=C(O)CO[C@@]12C#C/C=C\C#C[C@@H]3N(C(=O)Oc4ccccc4)c4ccccc4[C@]14O[C@@]34CCC2
In analogy to the rule of five, it has been proposed that ideal fragments should follow the rule of three, in which the molecular weight of a fragment is <300, the c LogP is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?