COc1ccc(-c2cc3nc(C)c(CCC(=O)Nc4ccccc4C(C)=O)c(C)n3n2)c(OC)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?