COc1ccc(-n2nnnc2C(c2ccccc2OC(F)(F)F)N2CCC(n3c(O)nc4ccccc43)CC2)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?