COc1ccc(Br)cc1CNC(=O)Cn1c(=O)c2cccn2c2ccc(F)cc21
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?