COc1ccc2[nH]c3c(c2c1)CCN1C(=O)C(CC(=O)NCC24C[C@H]5C[C@@H](C2)C[C@@H](C4)C5)C[C@H](C(=O)N(C(C)C)C(C)C)[C@@]31C
The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. How much is the polar surface area of this molecule?