COC(=O)C1=C(O)C(C(=O)OC)[C@]2(O)[C@H](C(=O)OC)[C@H]1C[C@@H](c1ccc(Cl)cc1)[C@H]2C(=O)OC
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?