COC(=O)[C@H]1C[C@H](OC(=O)NC2CC2)[C@@]2(O)CN(S(=O)(=O)c3ccc(C)cc3)CC2[C@H]1C(=O)OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?