CC1(C)C=C(/C=C2/N(S(=O)(=O)C(F)(F)F)C(/C=C3/N(S(=O)(=O)C(F)(F)F)C(C)(C#N)CC3(C)C)=CC2(C)C)N=C1/C=C1/CC(C)(C)C(=O)N1
The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. How much is the polar surface area of this molecule?