COc1c(-c2nc3ccc(N4CCN(C)CC4)nc3[nH]2)cc(OC)c2[nH]c(CO)nc12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?