CC1(C)Cc2cccc(OCC(=O)Nc3cc(S(C)(=O)=O)ccc3Cl)c2O1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?