Cc1nc(C(F)(F)F)ccc1C(=O)N1CCC1(C)C(=O)NS(=O)(=O)c1c(C)noc1C
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?