COc1ccc2c3c1O[C@H]1C4(OC)C=CC5(C6C(=O)N(c7ccccc7)C(=O)C64)C(C2)N(C)CCC315
In analogy to the rule of five, it has been proposed that ideal fragments should follow the rule of three, in which the molecular weight of a fragment is <300, the c LogP is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?