COc1ccc(CN2CCN(C(=O)C3CCN(C(=O)Nc4ccccc4)CC3)CC2)cc1OC
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?