Cc1ccc(C)c(NC(=O)CN(C)C(=O)Cc2ccc(Cl)cc2Cl)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?