CSc1nc(O)c(C(c2ccc(OC(C)C)cc2)c2c(O)nc(SC)nc2O)c(O)n1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?