COc1cccc(N2[C@@H](CC(C)=O)c3cc(C(F)(F)F)ccc3S2(=O)=O)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?