Cc1ccc2nc(N3C(=O)/C(=C4\C(=O)Nc5ccccc54)NC3=S)sc2c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?