COc1ccccc1NS(=O)(=O)c1ccc(C)c(NS(=O)(=O)c2cc(NC(C)=O)ccc2OC)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?