COc1ccc2oc(C(=O)OCC(=O)NCc3ccc(OC)c(OC)c3)c(C)c2c1
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?