COc1ccc(C2=NN(C(=O)c3ccccc3)C(O)(c3cc(F)c(Cl)cc3Cl)C2)cc1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?