CN(C(=O)c1cnc(O)cc1C(F)(F)F)c1ccc(Cl)c(Cl)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?