O=C1/C(=C/c2cccs2)N=C(c2ccccc2)N1C1Nc2cc3c(cc2S1)NC(N1C(=O)/C(=C/c2cccs2)N=C1c1ccccc1)S3
The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. How much is the polar surface area of this molecule?