COC(=O)Cc1c(C(=O)CC(C)(C)n2cnc(CCN3C(=O)CCC3=O)c2)[nH]c2ccccc12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?