COc1ccccc1C(CNC(=O)c1cccc(S(=O)(=O)N2c3ccccc3CC2C)c1)N(C)C
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?