COc1cccc(C(c2nnnn2-c2c(C)cccc2C)N2CCC(n3c(O)nc4ccccc43)CC2)c1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?