COc1cc(NC(=O)C2CCCN2S(=O)(=O)c2ccc3c(c2)CC(C)N3C(C)=O)cc(OC)c1
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?