COc1cccc2c1OC[C@@H](CO)[C@H]2N(C)C(=O)Nc1ccccc1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?