COC[C@@H]1[C@H]2OC(C)(C)O[C@H]2C(=O)N1C(=O)c1ccc(OC)cc1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?