C=C1[C@@H](OC(C)=O)/C=C/C2C3C(=O)[C@@](C)(OC(C)=O)[C@H]([C@H](OC(C)=O)[C@]4(O)[C@@H](C)C(=O)O[C@H]4[C@H]1Cl)[C@@]23C
The rule of three is typically followed by orally active drugs. The molecule meets rule of three or not?