COc1cc(/C=C2\N=C(c3ccccc3)N(c3nc4cc(C)c(C)cc4s3)C2=O)ccc1O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?