COc1ccc2c3c1O[C@H]1C4(OC)C=CC5(C6C(=O)N(c7ccccc7)C(=O)C64)C(C2)N(C)CCC315
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?