COc1ccc(OC)c(C2CC(=O)N(c3cccc(C)c3)C3=C2C(=O)OC3)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?