C/C1=C/CC[C@@]2(C)C(CC[C@@H]2C(C)/C=C/C(C)C)c2ccc(cc2C(=O)O)C[C@@H](O)CC1
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?