COc1cc2c(cc1OC)[C@H]1CN3CCC[C@H]3C=C1c1ccc(OC)c(O)c1-2
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?