COc1ccccc1CNC(=O)c1cc(-c2ccccc2C)n(CC2CC(c3cccc([N+](=O)[O-])c3)=NO2)n1
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?