COc1ccc2c(c1OC)C(=O)N1c3ccccc3C(=O)N(Cc3ccco3)C21
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?