COc1ccc(OC)c(C(=O)N(C[C@H]2CC[C@@H]([C@@H]3CC[C@H](CO)O3)O2)C(C(=O)NC(C)(C)C)c2ccc(-c3ccccc3)cc2)c1
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?