COc1ccc([C@H]2/C=C\CN(C(=O)C3CCCC3)[C@@H](C)C(=O)N2Cc2ccc(F)cc2)cc1
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?