COc1cc2nc(-c3cccs3)nc(N3C(c4ccc(O)cc4)=NNC(=O)c4ccccc43)c2cc1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?