COc1ccc(NC(=O)Cn2nnc(-c3ccccc3)c2COc2ccc(C(C)=O)cc2)cn1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?