C/C=C/c1ccc2c(c1)O[C@@H](CN(C)C(=O)c1ccc(F)cc1)[C@@H](C)CN([C@H](C)CO)S2(=O)=O
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?