Cc1cc(C)cc(-n2c(C)cc(/C=C3\SC(=Nc4ccc(Br)cc4)NC3=O)c2C)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?