N#CC1(C#N)N[C@@H](c2ccsc2)[C@H]2C(=O)N(c3ccccc3)C(=O)[C@H]21
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?