Oc1ccc(Cl)cc1C1=NC(NCN2CCN(CNC3=NC(c4ccccc4)CC(c4cc(Cl)ccc4O)=N3)CC2)=NC(c2ccccc2)C1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?