C[C@@H]1ON(C)[C@H]2C[C@H]3c4[nH]c5ccc(-c6ccc7c(c6)OCO7)cc5c4CCN3C(=O)[C@@H]12
In analogy to the rule of five, it has been proposed that ideal fragments should follow the rule of three, in which the molecular weight of a fragment is <300, the c LogP is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?