COc1ccc(NC(=O)N(C)C[C@@H]2Oc3c(NC(=O)Nc4c(C)noc4C)cccc3C(=O)N([C@@H](C)CO)C[C@@H]2C)cc1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?