CC(=O)Nc1ccc2c3c(cc(O)c2c1)N(C(=O)CCCCCCC(=O)N1CC(CCl)c2c1cc(O)c1cc(NC(C)=O)ccc21)CC3CCl
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?