Cc1nc(CCNC(=O)CC2C(=O)NCCN2CC(C)(C)C)nc2c1CCC2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?