Cn1cc(C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](CO)Cc2ccccc2)c2ccccc21
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?