COc1ccc(C2C3C(=O)N(N(C)c4ncc(C(F)(F)F)cc4Cl)C(=O)C3ON2C)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?