COc1ccc2[nH]c(C)c(C(=O)CN3CC(C)OC(C)C3)c2c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?