COc1cccc([C@H]2C/C(=N\NC(=O)C(=O)N[C@@H](C)c3ccccc3)c3ccccc3N2)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?