COc1cccc(C(C(=O)NC(C)(C)C)N(Cc2ccc(F)cc2)C(=O)CCC(=O)Nc2cc(C)on2)c1OC
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?