COC(=O)[C@@H](NC(=O)N1CCN(C(=O)C2COc3ccccc3O2)CC1)C(C)C
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?