COc1ccc(-c2oc(=O)c3cc(OC)c(OC)cc3c2C#C[C@]2(O)CC[C@H]3[C@@H]4CCc5cc(OC)ccc5[C@H]4CC[C@@]32C)cc1
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?