COc1ccc2c3c1OC1C(O)C=CC4[C@@H](C2)N(C)CC[C@]314.Cl
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?