O=C1[C@H]2C(c3ccc(Br)cc3)=NO[C@H]2C(=O)N1c1ccc(Cc2ccc(N3C(=O)[C@H]4ON=C(c5ccc(Br)cc5)[C@H]4C3=O)cc2)cc1
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?