COc1cc2c(cc1OCCN1CCN(CCOc3cc4c(cc3OC)C(=O)N3CCC[C@H]3C=N4)CC1)N=C[C@@H]1CCCN1C2=O
In analogy to the rule of five, it has been proposed that ideal fragments should follow the rule of three, in which the molecular weight of a fragment is <300, the c LogP is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?