O=C(Nc1ccccc1Cl)c1cc(C2CCCN(C(=O)c3cccs3)C2)on1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?