CC(C)NC(=O)N(C)C[C@H]1Oc2c(NC(=O)Cc3ccccc3)cccc2C(=O)N([C@H](C)CO)C[C@@H]1C
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?