Cc1ccc(C2(c3ccccc3)NC(=O)N(CC(=O)NC3CCS(=O)(=O)C3)C2=O)cc1C
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?