COC1(OC)C[C@H](C)[C@@]23O[C@]24c2cc(O)c5c(c2N[C@H]3C#C/C=C\C#C[C@]14O)C(=O)c1ccccc1C5=O
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?