COc1ccc(-c2ccc3c(c2)O[C@H](CN(C)C(=O)Nc2ccccc2F)[C@@H](C)CN([C@H](C)CO)S3(=O)=O)cc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?