COc1cc2c(cc1OC)-c1c3cc(O)ccc3nn[n+]1CC2.[Cl-]
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?