CN1CCN(C(CNC(=O)C(=O)Nc2ccc(F)cc2F)c2ccc3c(c2)OCO3)CC1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?