COc1ccc(COC(=O)NN=C2CC(O)C(O)C3C2CCC2C(=O)N(c4ccc(F)cc4F)C(=O)C23)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?