COc1cccc(/C=C2\C(=O)N(C(=O)c3ccc(NC(C)=O)cc3)N=C2C)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?