COc1cc([C@@H]2c3cc4c(cc3[C@H](OC3OC5COC(C(C)C)OC5C(O)C3O)C3COC(=O)[C@@H]32)OCO4)cc(OC)c1O
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?