COc1ccc(C2CC(=O)c3c(O)cc(O)cc3O2)c(CC=C(C)C)c1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?