COc1cccc(-c2nc(CS(=O)(=O)CC(=O)Nc3ccc(C(C)=O)cc3)c(C)o2)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?