CC(=O)NC(CSC1=C2NC(=O)/C=C\C=C/C=C\C(C)C(O)CC(=O)/C(C)=C\CC(O)/C=C\C(C)C(O)C(C)C=C(C)C(=O)c3c(O)c(C)cc(c3C1=O)C2=O)C(=O)O
The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. How much is the polar surface area of this molecule?