Cc1cc2[nH]c3c(C#N)c(-c4ccccc4)c(/C=N/c4ccc(Cl)cc4)c(=O)n3c2cc1C
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?