COc1cc(S(=O)(=O)Nc2nc(-c3ccc(N4C(=O)/C(=C/C=C/c5ccccc5)N=C4c4ccccc4)cc3)cs2)ccc1Cl
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?