Cc1ccc(NC(=O)N2CCN(c3cc(-c4noc(C)n4)ccc3C)CC2)c(F)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?