COc1ccc(OC)c(/C=N/N=C2\C(=O)Nc3c(Cl)cc(Cl)cc32)c1
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?