COc1ccc(-c2ccc3[nH]c4c(c3c2)CCN2C(=O)[C@@H]([C@H](C)O)[C@@H](N(C)C(=O)Nc3ccc(F)cc3)C[C@@H]42)cc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?