COc1ccc(OC)c(NC(=O)CCC/C(CC(=O)c2ccc(O)c(OC)c2)=N\Nc2ccc([N+](=O)[O-])cc2)c1
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?