CCOC1=C2CN(S(=O)(=O)c3ccc(C)cc3)[C@H](c3cccc4ccccc34)C[C@H]2C(C#N)(C#N)C(C#N)(C#N)C1
Molecules with a polar surface area of greater than 60 angstroms squared (Å2) is hard to pass brain blood barrier. What's the psa of this molecule?