COc1ccc(C2CC(C(F)(F)F)n3ncc(C(=O)NCc4cccnc4)c3N2)cc1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?