COc1ccccc1N=C(S)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?