COc1ccc(C)cc1S(=O)(=O)Nc1cc2c3c(c1)C(C)C(=O)N3CCC2
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?