COC(=O)C1=C(C)N(c2ccc(C(=O)OC)cc2)C(=O)C1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?