COc1ccc2c(c1)C(=O)N1[C@H]3c4cc(Br)ccc4OC[C@@H]3[C@H](c3ccccc3)[C@]1(C)C(=O)N2
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?