Cc1ccc(C(=O)CSC2=C(C#N)C(c3ccco3)C3=C(O)CCCC3=N2)cc1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?