COC(=O)c1ccc(CSc2nc(O)c3cnn(-c4ccc(C)cc4)c3n2)o1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?