COc1ccc(N2CC(C(=O)N[C@@H](C)C(=O)NCc3ccccc3OC)CC2=O)cc1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?