COc1ccc(N(CC(=O)NC(C)C)S(=O)(=O)c2ccc(NC(C)=O)cc2)cc1
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?