COc1ccccc1C1C(C(=O)c2ccc(C)cc2)=C(O)C(=O)N1CC(C)O
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?