COc1cccc2cc(C(C)N(CCCN3CCOCC3)C(S)=Nc3cccc(C)c3)oc12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?