COc1ccc(-c2nc(-c3ccccc3)c(-c3ccc(F)cc3)[nH]2)c(OC)c1C
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?