COc1ccc(NC(=O)CNC(=O)Cn2cnc3sc4c(c3c2=O)CCCC4)cc1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?