COc1cc2c(cc1OC)CN(C1CC(=O)N(c3c(C)cccc3C)C1=O)CC2
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?