COc1cccc(C(=O)C2CCCN(C(=O)c3cccc(C#CC(C)(C)O)c3)C2)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?