O=C(CN1C(=O)C2CC=CCC2C1=O)Nc1nnc(SCc2c(Cl)cccc2Cl)s1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?