CC1=C(C#N)C(NC(=O)C(C)(C)C)(C(F)(F)F)C(=O)N1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?