COc1cc2cc(CN(CCCO)S(=O)(=O)c3ccccc3Cl)c(O)nc2cc1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?