COc1cccc(NC(=O)CC(c2ccc(OC(C)C)cc2)c2ccccc2OC)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?