O=C(NCC1COc2ccccc2O1)C1CCCN(S(=O)(=O)c2c[nH]cn2)C1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?