CC(=O)c1c(C)[nH]c(C(=O)/C(C#N)=C/c2cccc(C)c2)c1C
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?