N#CC1=C(N)NC(SCC(=O)Nc2ccccc2)=C(C#N)C12CCCC2
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?