O=C(CSc1n[nH]c2c3cc(S(=O)(=O)N4CCOCC4)ccc3nc-2n1)Nc1ccccc1Cl
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?