COc1ccc(CCNC(=O)c2cc3c(=O)n(C)c4ccccc4c3s2)cc1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?