CC(C)(Oc1ccc(Br)cc1)C(=O)Nc1cc(-c2nc3ccccc3[nH]2)ccc1Cl
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?