C[C@H]1Cc2c(COc3ccccc3)nc3c(c2CO1)CN(C(=O)Nc1cccc(C#N)c1)CC3
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?