COC(=O)C1CN(C(=O)C(C)Oc2cc(C)ccc2C(C)C)c2ccccc2O1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?