COc1cc2nc(SCC(=O)Nc3ccccc3F)n3nc(-c4ccccc4)nc3c2cc1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?