COc1cc(/C=C(\NC(C)=O)C(=O)NC(C)(C)C)ccc1OC(C)=O
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?