O=C(Cc1ccccc1F)N1CCC(c2nc(O)c3nnn(Cc4cccc(Cl)c4)c3n2)CC1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?