CCN(CC(=O)Nc1ccccc1C(F)(F)F)C(=O)CCc1c(C)nc(O)c(C#N)c1C
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?