COc1cc(C2c3c(oc4ccc(C)cc4c3=O)C(=O)N2Cc2ccc(F)cc2)ccc1O
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?