COc1ccc(C(C(=O)NC(C)(C)C)N(Cc2ccc(C)cc2)C(=O)CCC(=O)Nc2cc(C)on2)cc1
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?