O=C(Nc1c(C(=O)N2CCN(c3ccccc3)CC2)oc2ccccc12)c1ccc(Br)o1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?