COc1cc2c(cc1OC)CN(C(S)=Nc1ccc(OC(F)F)cc1)CC2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?