COC(=O)C1OC(=O)C2OC23[C@@]1(C)CCC1[C@@]3(C)C(OC(C)=O)CC2C(C)(C)C(=O)CC[C@@]21C
In analogy to the rule of five, it has been proposed that ideal fragments should follow the rule of three, in which the molecular weight of a fragment is <300, the c LogP is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?