COc1ccc(NC(=O)N2CCc3nc(-c4ccc(OC)cc4C)c4c(c3C2)CO[C@@H](c2ccccc2)C4)cc1
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?