COc1ccc(OC)c(S(=O)(=O)Nc2cc3c4c(c2)C(C)C(=O)N4CCC3)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?