O=C(NC1(C(F)(F)F)NC(=O)N(CCc2ccccc2)C1=O)c1ccccc1Cl
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?