COc1ccc(N(CC(=O)NCc2ccc(Cl)cc2)S(=O)(=O)c2c(C)n[nH]c2C)cc1
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?