COc1cc(NC(=O)CC(c2cccs2)N2Cc3ccccc3C2=O)cc(OC)c1OC
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?