COc1ccc(-c2nc3sc(CCNC(=O)C(=O)Nc4cc(C)cc(C)c4)c(C)n3n2)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?