CC(C)(C)OC(=O)N1CCN(C(=O)c2[nH]cnc2C(=O)N2CCN(c3ccccc3)CC2)CC1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?