O=C(O)C[C@]1(C(=O)Nc2ccc(F)cc2)CC(/C=C/c2ccccc2)=NO1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?