CCOc1ccc(N2C(=O)/C(=C\c3ccc(OC)c(O)c3)S(=O)(=O)C2c2cccc([N+](=O)[O-])c2)cc1
Molecules with a polar surface area of greater than 60 angstroms squared (Å2) is hard to pass brain blood barrier. What's the psa of this molecule?