Cc1ccccc1Cn1nnc2c(O)nc(C3CCCN(C(=O)c4ccc(C(C)(C)C)cc4)C3)nc21
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?