Cc1coc(C)c1C(=O)CC1(O)C(=O)N(C)c2ccc(Cl)cc21
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?