CO/C(O)=C(\C)Sc1nc(N2CCOCC2)c2c(c1C#N)CC(C)(C)OC2
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?