COC(=O)c1cccc(C23CC4(C2)[C@@H](c2ccccc2)N(Cc2ccc(C(F)(F)F)cc2)C[C@@H]4C3c2ccccc2)c1
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?