Cc1ccc2c(c1)C(c1ccccc1)N(C(=O)c1ccc(OC(C)C)cc1)CC(=O)N2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?