COc1ccc(NC(=O)c2cccc(N3C(=O)c4ccc(C(=O)Nc5ccc(OC)c(O)c5)cc4C3=O)c2)cc1O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?