CCOC(=O)c1c(S(=O)(=O)NCC(=O)N(C)c2ccc(C)cc2)c(C)n(C)c1C
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?