O=C(Cc1cccc(NC(=O)C2CCN(C(=O)C3CCC3)CC2)c1)Nc1cccc(C(=O)N2CCCC2)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?