COc1cc2c(cc1OC)C(c1cc3ccc(C)cc3nc1O)N(C(=O)c1ccco1)CC2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?