COc1cc([C@H]2c3[nH]c4ccccc4c3C[C@H]3C(=O)N4[C@@H](Cc5c([nH]c6ccccc56)[C@@H]4c4cc(OC)c(OC)c(OC)c4)C(=O)N32)cc(OC)c1OC
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?