COc1ccc2c(CNCC(C)c3ccccc3)c(C(=O)O)n(Cc3ccc(F)cc3Cl)c2c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?