Cc1ccc(NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2Cc3ccccc3CN2)cc1
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?