COc1ccc(C2NC(Cc3ccccc3)(C(=O)O)C3C(=O)N(c4ccccc4OC)C(=O)C23)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?