COC(=O)[C@@]1(Cc2ccc(OC)cc2)[C@H]2[C@H](CC(=O)C(=O)N(C)C)C(=O)C[C@H]2CN1C(=O)c1ccccc1
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?