Cc1ccccc1NC(=O)Cn1cnc2c(oc3nc4c(cc32)COC(C)(C)C4)c1=O
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?