CCOc1cc(C2c3c(C)n[nH]c3C(=O)N2c2ccc(C)cc2)ccc1O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?