COc1cc(C(CC(=O)Nc2ccc(Cl)cn2)N2Cc3ccccc3C2=O)cc(OC)c1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?