COc1ccnc(C[S+]([O-])c2nc3cc(C(O)(F)F)ccc3[n-]2)c1OC.[Na+]
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?