COc1cccc(C2C(C#N)=C(C)N=C3CC(C)(C)CC(O)=C32)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?