COc1cc(Cl)c(C)cc1NC(=O)C1CCCN(c2ncnc3onc(-c4ccc(F)cc4)c23)C1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?