COc1cc2c(cc1OC)-c1c(O)c(OC)cc3c1[C@@H](C2)N(C)CC3
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?