Cc1ccc(N2C(=O)C(NC(=O)c3c(F)cccc3F)(C(F)(F)F)C3=C2CC(C)(C)CC3=O)cc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?