COc1cccc(N2CCN(C(=O)CCNS(=O)(=O)c3ccc4c(c3)c(=O)n(C)c(=O)n4C)CC2)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?