O=C(O)CC12CC3CC(C1)CC(n1ncc(NCC4CCCO4)c(Cl)c1=O)(C3)C2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?