O=C(NC12CC3CC(CC(C3)C1)C2)c1cc(F)c(F)cc1Cl
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?