COc1ccc(CCN(C)C(=O)c2ccc(S(=O)(=O)Nc3ccccc3C)cc2)cc1OC
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?