COc1ccc(C2CC(=O)c3c([nH]c(C(=O)OC4CCC(C)CC4)c3C)C2)cc1OC
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?