Cc1cnc(C(=O)NC2CC(C)(C)Cc3c2cnn3-c2ccccc2)cn1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?