O=C(Nc1ncc(Cc2ccc(F)cc2)s1)c1ccc2c(c1)CC(c1ccccc1)OC2=O
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?