COc1cccc(CNC(=O)CN2C(=O)N(c3c(C)cccc3C)S(=O)(=O)c3ccccc32)c1OC
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?