CC(C)C(NC(=O)CCNC(=O)c1ccc(C(C)(C)C)cc1)c1nc2ccccc2[nH]1
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?