COC(=O)C1=C(C)N(Cc2ccccc2)C2=C(C(C)=O)C(c3ccccc3)[C@@](O)(C(=O)OC)C(=O)N2C1c1ccccc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?