COc1ccc(-c2cc(=O)oc3c(C)c(OCC(=O)NC[C@H]4CC[C@H](C(=O)O)CC4)ccc23)cc1
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?