COc1ccc(C)cc1Nc1nc2c(S(=O)(=O)c3cccc(Cl)c3)nnn2c2ccsc12
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?