COc1ccc(NCc2cc3ccc(OC)cc3n(CC(=O)Nc3ccc(C)c(C)c3)c2=O)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?