Cc1ccc(-n2nc(C)c3c(C)cc(=O)n(CC(=O)Nc4ccc(Br)cc4F)c32)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?