COc1cc(C(=O)NC2(C(F)(F)F)C(=O)NC(C)=C2C#N)cc(OC)c1OC
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?