N#C[C@@H]1[C@@H]2C(=O)N(c3ccc4c(c3)OCCO4)C(=O)[C@@H]2C2c3ccccc3C=CN21
Molecules with a polar surface area of greater than 60 angstroms squared (Å2) is hard to pass brain blood barrier. What's the psa of this molecule?