CCN1C(=O)[C@@H]2[C@@H](C[C@@H]3C4=C(C(=O)N5C(=O)O/C(=N\CC6CC6)[C@]5(C)[C@@H]42)[C@H](C)[C@@H]2C(=O)N(CC)C(=O)[C@H]32)C1=O
The polar surface area (PSA) or topological polar surface area (TPSA) of a molecule is defined as the surface sum over all polar atoms or molecules, primarily oxygen and nitrogen, also including their attached hydrogen atoms. PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. How much is the polar surface area of this molecule?