COc1cc(/C=C2\CCn3c2nc2cc(C(=O)O)ccc2c3=O)ccc1OC(F)F
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?