COc1ccc(S(=O)(=O)Nc2cc3c4c(c2)C(C)C(=O)N4CCC3)cc1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?