COc1cccc(/C=C2\SC(=S)N(CCC(=O)NCCc3ccc(O)cc3)C2=O)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?