COC(=O)c1ccccc1N1C(=O)[C@H]2ON=C(c3ccc(Br)cc3)[C@H]2C1=O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?