COc1ccc(CCN2C(=O)NC(NS(=O)(=O)c3ccc(NC(C)=O)cc3)(C(F)(F)F)C2=O)cc1OC
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?