COc1ccc(-c2cc3nc(C)c(CCC(=O)Nc4cccc(C(F)(F)F)c4)c(C)n3n2)c(OC)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?