COc1ccc(C(C(=O)Nc2ccc(C(C)C)cc2)N(C)C(=O)CNC(C)=O)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?