COc1cc2[nH]c3c(N4CCC(C(N)=O)CC4)ncnc3c2cc1OC
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?