Cc1cc(C)cc(NC(=O)N2CCC3(CC2)Oc2ccccc2C(=O)N3Cc2ccccc2F)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?