COc1cc(NC(=O)c2ccco2)c(C(=O)OCC(=O)Nc2ncc(Cl)cc2Cl)cc1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?