COc1ccc(C2c3c(n(C)c4ccccc34)C(=O)N2CC(=O)Nc2c(C)cc(C)cc2C)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?