COc1ccc(OC)c(CNC(=O)Cn2nc(C)c3c(C)n(-c4ccccc4)nc3c2=O)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?