Cc1nn(C2CCOC(C)(C)C2)c2c1C(c1ccc(OC(C)C)cc1)SCC(=O)N2
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?