O=C(CSCc1nc(O)c2nnn(Cc3ccc(F)cc3)c2n1)Nc1c(Cl)cc(Cl)cc1Cl
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?