Cc1ccc(C2N=C(S)NC(c3ccc(C)cc3)C23C(=O)NC(=O)NC3=O)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?