COC(=O)CCC(=O)OC1(C)C(=O)C2=CN(Cc3ccc(OC)cc3)C(c3ccc(OC)cc3)=CC2=C(Br)C1=O
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?