COc1ccc(N2CCN(C(=O)CN3C(=O)NC4(CCCc5ccccc54)C3=O)CC2)cc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?