Cc1nc(SC2CC(=O)N(c3cc(Cl)cc(Cl)c3)C2=O)nc2c1CCCC2
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?