COc1ccc(NC(=O)CCCN2C(=O)CCn3nc(-c4cn(C)c5ccccc45)cc32)cc1OC
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?