COc1ccc(NC(=O)c2cn3c4c(ccc(Cl)c4c2=O)OC(C)C3)cc1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?