ER-beta recruit coregulator proteins to regulate gene transcription, including coactivators and corepressors that have various activities, such as altering chromatin architecture, modifying histones, and activating RNA polymerase II. The p160s or SRCs, a specific class of coactivators, interact with both ER-beta and ER-beta by inserting an LXXLL sequence into a hydrophobic groove on the ER ligand binding domain. This hydrophobic groove represents a novel target for small molecule coactivator binding inhibitors (CBIs) that could have therapeutic potential in breast cancer treatment. Is this molecule inhibitor of ER-beta? ER-beta recruit coregulator proteins to regulate gene transcription, including coactivators and corepressors that have various activities, such as altering chromatin architecture, modifying histones, and activating RNA polymerase II. The p160s or SRCs, a specific class of coactivators, interact with both ER-beta and ER-beta by inserting an LXXLL sequence into a hydrophobic groove on the ER ligand binding domain. This hydrophobic groove represents a novel target for small molecule coactivator binding inhibitors (CBIs) that could have therapeutic potential in breast cancer treatment. Can this molecule inhibite ER-beta? ER-beta recruit coregulator proteins to regulate gene transcription, including coactivators and corepressors that have various activities, such as altering chromatin architecture, modifying histones, and activating RNA polymerase II. The p160s or SRCs, a specific class of coactivators, interact with both ER-beta and ER-beta by inserting an LXXLL sequence into a hydrophobic groove on the ER ligand binding domain. This hydrophobic groove represents a novel target for small molecule coactivator binding inhibitors (CBIs) that could have therapeutic potential in breast cancer treatment. Is this molecule effective to ER-beta? ER-beta recruit coregulator proteins to regulate gene transcription, including coactivators and corepressors that have various activities, such as altering chromatin architecture, modifying histones, and activating RNA polymerase II. The p160s or SRCs, a specific class of coactivators, interact with both ER-beta and ER-beta by inserting an LXXLL sequence into a hydrophobic groove on the ER ligand binding domain. This hydrophobic groove represents a novel target for small molecule coactivator binding inhibitors (CBIs) that could have therapeutic potential in breast cancer treatment. Is this molecule effective to this assay?