EphA4 is a member of the large Eph family of receptor tyrosine kinases. The signaling ability of EphA4, and the other nine closely related EphA receptors, is activated by binding the six GPI-linked ephrin-A ligands. In addition, EphA4 also binds the three transmembrane ephrin-B ligands, which are the ligands for the other class of Eph receptors, the EphB receptors (EphB1-EphB6). Eph receptor-ephrin interaction requires cell-cell contact because both the receptor and the ligand are membrane-bound. Importantly, signals are generated both through the Eph receptor kinase domain (forward signals) and through signaling molecules associated with the ephrins (reverse signals). The EphA4 receptor tyrosine kinase plays a critical role in the inhibition of axon regeneration that occurs after spinal cord injury. Axons in EphA4 knockout mice can regenerate past the site of injury and re-establish severed connections resulting in functional recovery. Other evidence suggests that EphA4 plays an inhibitory role in axonal and dendritic growth in other regions of the central nervous system as well. Furthermore, EphA4 has been implicated in the maintenance of platelet aggregation during thrombus formation and in prostate cancer cell growth. Thus, inhibiting EphA4 function is a very promising new approach with high potential for a number of therapeutic applications. Is this molecule inhibitor of EphA4? EphA4 is a member of the large Eph family of receptor tyrosine kinases. The signaling ability of EphA4, and the other nine closely related EphA receptors, is activated by binding the six GPI-linked ephrin-A ligands. In addition, EphA4 also binds the three transmembrane ephrin-B ligands, which are the ligands for the other class of Eph receptors, the EphB receptors (EphB1-EphB6). Eph receptor-ephrin interaction requires cell-cell contact because both the receptor and the ligand are membrane-bound. Importantly, signals are generated both through the Eph receptor kinase domain (forward signals) and through signaling molecules associated with the ephrins (reverse signals). The EphA4 receptor tyrosine kinase plays a critical role in the inhibition of axon regeneration that occurs after spinal cord injury. Axons in EphA4 knockout mice can regenerate past the site of injury and re-establish severed connections resulting in functional recovery. Other evidence suggests that EphA4 plays an inhibitory role in axonal and dendritic growth in other regions of the central nervous system as well. Furthermore, EphA4 has been implicated in the maintenance of platelet aggregation during thrombus formation and in prostate cancer cell growth. Thus, inhibiting EphA4 function is a very promising new approach with high potential for a number of therapeutic applications. Can this molecule inhibite EphA4? EphA4 is a member of the large Eph family of receptor tyrosine kinases. The signaling ability of EphA4, and the other nine closely related EphA receptors, is activated by binding the six GPI-linked ephrin-A ligands. In addition, EphA4 also binds the three transmembrane ephrin-B ligands, which are the ligands for the other class of Eph receptors, the EphB receptors (EphB1-EphB6). Eph receptor-ephrin interaction requires cell-cell contact because both the receptor and the ligand are membrane-bound. Importantly, signals are generated both through the Eph receptor kinase domain (forward signals) and through signaling molecules associated with the ephrins (reverse signals). The EphA4 receptor tyrosine kinase plays a critical role in the inhibition of axon regeneration that occurs after spinal cord injury. Axons in EphA4 knockout mice can regenerate past the site of injury and re-establish severed connections resulting in functional recovery. Other evidence suggests that EphA4 plays an inhibitory role in axonal and dendritic growth in other regions of the central nervous system as well. Furthermore, EphA4 has been implicated in the maintenance of platelet aggregation during thrombus formation and in prostate cancer cell growth. Thus, inhibiting EphA4 function is a very promising new approach with high potential for a number of therapeutic applications. Is this molecule effective to EphA4? EphA4 is a member of the large Eph family of receptor tyrosine kinases. The signaling ability of EphA4, and the other nine closely related EphA receptors, is activated by binding the six GPI-linked ephrin-A ligands. In addition, EphA4 also binds the three transmembrane ephrin-B ligands, which are the ligands for the other class of Eph receptors, the EphB receptors (EphB1-EphB6). The EphA4 receptor tyrosine kinase plays a critical role in the inhibition of axon regeneration that occurs after spinal cord injury. Axons in EphA4 knockout mice can regenerate past the site of injury and re-establish severed connections resulting in functional recovery. Other evidence suggests that EphA4 plays an inhibitory role in axonal and dendritic growth in other regions of the central nervous system as well. Furthermore, EphA4 has been implicated in the maintenance of platelet aggregation during thrombus formation and in prostate cancer cell growth. Thus, inhibiting EphA4 function is a very promising new approach with high potential for a number of therapeutic applications. Can this molecule inhibite EphA4? EphA4 is a receptor tyrosine kinase that is part of a large family of receptors called Eph. The signaling ability of EphA4, along with other EphA receptors, is activated by binding to GPI-linked ephrin-A ligands, and it also binds to transmembrane ephrin-B ligands, which are the ligands for another class of Eph receptors called the EphB receptors. Signals are generated both through the Eph receptor kinase domain and through signaling molecules associated with the ephrins. EphA4 plays an important role in inhibiting axon regeneration after spinal cord injury, and inhibiting its function shows promise for therapeutic applications in spinal cord injury, platelet aggregation during thrombus formation, prostate cancer cell growth, and other regions of the central nervous system. Can this molecule inhibite EphA4? EphA4 is a receptor tyrosine kinase that is part of a large family of receptors called Eph. The signaling ability of EphA4, along with other EphA receptors, is activated by binding to GPI-linked ephrin-A ligands, and it also binds to transmembrane ephrin-B ligands, which are the ligands for another class of Eph receptors called the EphB receptors. Signals are generated both through the Eph receptor kinase domain and through signaling molecules associated with the ephrins. EphA4 plays an important role in inhibiting axon regeneration after spinal cord injury, and inhibiting its function shows promise for therapeutic applications in spinal cord injury, platelet aggregation during thrombus formation, prostate cancer cell growth, and other regions of the central nervous system. Is this molecule inhibitor of EphA4? EphA4 is a receptor tyrosine kinase that is part of a large family of receptors called Eph. The signaling ability of EphA4, along with other EphA receptors, is activated by binding to GPI-linked ephrin-A ligands, and it also binds to transmembrane ephrin-B ligands, which are the ligands for another class of Eph receptors called the EphB receptors. Signals are generated both through the Eph receptor kinase domain and through signaling molecules associated with the ephrins. EphA4 plays an important role in inhibiting axon regeneration after spinal cord injury, and inhibiting its function shows promise for therapeutic applications in spinal cord injury, platelet aggregation during thrombus formation, prostate cancer cell growth, and other regions of the central nervous system. Is this molecule effective to this assay?