The rule of three governs the characteristics of an orally active drug. According to this rule, a drug molecule should fulfill four criteria namely: (1) a molecular weight of each fragment should be less than 300, (2) the calculated partition coefficient (c Log P) of the drug must be less than or equal to three, (3) the drug should contain no more than three hydrogen bond donors, and (4) the drug should contain no more than three hydrogen bond acceptors. These requirements ensure that the drug can be well absorbed in the gastrointestinal tract and reaches the targeted site of action. Therefore, complying with the rule of three is essential for a drug to be approved for oral administration.Does the molecule abide by the rule of three?