Orally active drugs are a type of medication that are intended to be administered orally, by mouth. A common practice in pharmacology is to adhere to the "rule of three" when it comes to orally active drugs. This rule suggests that success and effectiveness of a drug in treating an illness or condition is highly likely when it satisfies three criteria: it should be highly potent, highly selective, and highly bioavailable. Therefore, in order to ensure the effectiveness and safety of a drug, it is typically recommended to follow the rule of three when developing orally active drugs.Does the molecule comply with the rule of three?