COc1ccc(OC)c(-c2cc(C(=O)Nc3sc4c(c3C#N)CCC(C)C4)c3ccccc3n2)c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?