Cc1c(C(=O)O)cccc1-n1c(C)cc(/C=C(/C#N)C(=O)NCc2ccccc2)c1C
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?