Cc1cc(O)cc2c1C(c1ccc(F)cc1)CC1(CC(C)(C)N=C(S)N1)O2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?