COc1cc(OC)c(NC(=O)CN(C)S(=O)(=O)c2ccc(-c3ccc(O)nn3)s2)cc1Cl
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?