COc1ccc(CN2CCN(C(=O)CCC(=O)Nc3nnc(CC(C)C)s3)CC2)cc1F
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?