Cc1sc2ncnc(N3CCC(C(=O)Nc4nnc(SCc5ccccc5F)s4)CC3)c2c1C
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?