O=C1c2ccccc2-c2onc3c(N4CCN(C5CCCCC5)CC4)cc(NCCO)c1c23
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?