COc1ccc2nc(COC(=O)c3ccco3)c(C(C)=O)[n+]([O-])c2c1
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?