O=c1cc(-c2ccccc2Cl)oc2c(NS(=O)(=O)c3cccs3)ccc(O)c12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?