COc1ccccc1Nc1nc2c(S(=O)(=O)c3ccc(C(C)C)cc3)nnn2c2ccsc12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?