COc1ccc(CCNc2oc(-c3ccc(OC)c(OC)c3)nc2P(=O)(OC)OC)cc1OC
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?