COC(=O)c1c(NC(=O)/C(C#N)=C/c2ccc(OC)cc2)sc2c1C(C(=O)OC)CC2
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?