Cc1sc2nc3c(SC(C)C(=O)O)cc(C(=O)c4ccccc4O)cn3c(=O)c2c1C
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?