COc1[nH]nc(C(=O)Nc2cc(F)ccc2C)c1[N+](=O)[O-]
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?