COc1ccc(-c2[nH]ncc2CN2CCC(C(=O)N3CCOCC3)CC2)c(F)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?