COc1ccc(Cl)cc1NC(=O)Cn1ccn(-c2cc(C)cc(C)c2)c(=O)c1=O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?