COc1ccccc1NS(=O)(=O)c1cc(NC(=O)CNC(=O)c2ccc(C)s2)ccc1Cl
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?