Cc1cc(C)c(S(=O)(=O)NCCc2sc3nc(-c4ccc(F)cc4)nn3c2C)c(C)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?