COc1ccc(C(=O)C2=C(O)C(=O)N(c3cc(C)on3)C2c2ccc(OC)c(OC)c2)cc1OC
Molecules with a polar surface area of greater than 140 angstroms squared (Å2) tend to be poor at permeating cell membranes. What's the psa of this molecule?