COc1cc2c(=O)c(-c3ccc(O)cc3)coc2cc1OC1OC(CO)C(O)C(O)C1O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?