Cc1ccc(C)c2nc(O)c(CCNC(=O)c3ccc(S(=O)(=O)N4CCOCC4)cc3)cc12
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?