Cc1ccccc1Nc1nc(N)nc(COC(=O)[C@@H](NC(=O)c2c(F)cccc2F)C(C)C)n1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?