COc1ccc(C(=O)N/C(=C\c2cn(C)c3ccccc23)C(=O)OCC(C)C)cc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?