Cc1ccc(C2CN(C)C3(C(=O)Nc4ccccc43)C23COc2ccccc2C3=O)cc1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?