Cc1nc(-c2ccc(C)c(N3CCN(C(=O)Nc4ccc(Br)cc4)CC3)c2)no1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?