CCOC(=O)C1(Cc2ccccc2C(F)(F)F)CCN(C(=O)c2cc(C(C)=O)[nH]n2)CC1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?