COc1ccc(Cl)cc1-n1c(=S)sc2c(=O)n(-c3ccc(F)cc3)c(SCC(=O)O)nc21
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?