CC1CN(c2ccc(N=C(S)Nc3ccc(N4CC(C)OC(C)C4)cc3)cc2)CC(C)O1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?