Cc1ccc(NC(=O)c2cnc(SCC(=O)N3CCCc4ccccc43)n(C)c2=O)cc1C
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?