COC(=O)c1ccc(NC(=O)C23CC4CC(C2)CC(n2cnc(Cl)n2)(C4)C3)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?