COc1cccc(NC2=CC(c3ccc(C(C)C)cc3)N(c3cccc(OC)c3)C2=O)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?