C[C@@]12CCC3[C@]4(C)CCC[C@@](C)(C(=O)Nc5ccc(Cl)cc5)C4CC[C@]3(CC1=O)C2
The rule of three is typically followed by orally active drugs, which have a molecular weight of <300, a c LogP of ≤3, a hydrogen bond donor count of ≤3 and a hydrogen bond acceptor count of ≤3. Does the molecule comply with the rule of three?