COC(=O)c1sc2nc(CN3CCN(c4ccc(OC)cc4)CC3)nc(O)c2c1C
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?