COC(=O)c1c(-c2ccc(Cl)cc2)noc1N1CCN(c2cccc(C(F)(F)F)c2)CC1
Orally active drug usually follows the rule of three, in which the molecular weight of a fragment is <300, the c Log P is ≤3, the number of hydrogen bond donors is ≤3 and the number of hydrogen bond acceptors is ≤3. The molecule meets rule of three or not?