Cc1cccc(N2C(S)=NC3c4cc(Cl)ccc4OC2(C)C3C(=O)N(C)C)c1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?