COc1ccc(Cn2ccc3nc(C)c(C(=O)NCc4ccc(F)cc4)cc3c2=O)cc1
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?