CCO.COc1cc(C2C(C#N)=C(N)N(N(C)C)C3=C2C(=O)CC(C)(C)C3)ccc1O
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?