COc1cc2c(cc1OC)C(c1ccc3c(c1)OCO3)C1=C(O)CC(C)(C)CC1=N2
An acid's negative base-10 logarithmic dissociation constant (pKa) follows directly from its underlying thermodynamics; the negative pKa is directly proportional to its standard Gibbs free energy change. What is the negative pKa value of this molecule?