COc1ccc(-n2cc(CN(C)Cc3n[nH]c(O)n3)c(-c3cccc(F)c3)n2)cc1
An acid's negative base-10 logarithmic dissociation constant (pka) follows directly from its underlying thermodynamics; pKa is directly proportional to its standard Gibbs free energy change. What is the pka value of this molecule?