O=C(COC(=O)C1CC2CCCC(C1)C2=O)Nc1nc(-c2ccc(F)c(F)c2)cs1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?