COc1cc(C(c2sc3nc(C)nn3c2O)N2CCC3(CC2)OCCO3)cc(OC)c1OC
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?