CCn1cc2c(n1)-c1c(oc(C(=O)Nc3cccc(C(F)(F)F)c3)c1C)CC2
The negative base-10 logarithmic of dissociation constant (pka) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the pka value of this molecule?