COc1cccc(C(c2c(O)cc(C)n(Cc3ccco3)c2=O)N2CCC(C)CC2)c1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?