Cc1ccc(CNC(=O)Cn2cnc3c(NC(=O)OCc4ccccc4)ncnc32)o1
The negative base-10 logarithmic of dissociation constant (pKa) for an acid is a direct consequence of the underlying thermodynamics of the dissociation reaction; the negative pKa value is directly proportional to the standard Gibbs free energy change for the reaction. What is the negative pKa value of this molecule?