The test efflux ratio can be determined in the MDCK-MDR1 cell, by measuring the apparent permeability values of test compound for both the apical to basal (A>B) and basal to apical (B>A).
The efflux ratios can be determined in the MDCK-MDR1 cell line, by measuring the apparent permeability (Papp) values of test compound for both the apical to basal (A>B) and basal to apical (B>A).