It has been shown that HCCs appear hypointens in HP images (most likely due to the down-regulation of OATP1 and the increased expression of MRP2), even though they lack the characteristic enhancement features of HCCs in early dynamic things, for instance, due to the persistent portal venous blood supply on early HCC , . Thus, Gd-EOB-DTPA might help differentiate small HCCs from dysplastic nodules and pseudovascular lesions, which do not commonly show hypointensity during the HP , trial also appeared isoineintetrhyperintens in relation to the surrounding liver parenchyma, most likely because of the high MRP2 expression in the canalic probably CCs appeared isointens to hyperintens in relation to the surrounding liver parenchyma, most likely because of the high MRP2 expression in the canalicular membrane and the down vascular lesions, which do not commonly show hypointensity during the HP , . In our trial, however, 8 HCCs appeared isointens to hyperintens in relation to the surrounding liver parenchyma, most likely because of the high MRP2 expression in the canalicular membrane and the down cular appeared isointens to hyperintens in relation to the surrounding liver parenchyma, most likely because of the high MRP2 expression in the canalicular membrane and the down-regulation of MRP2 al in the canalicular membrane and the down-regulation of MRP2 nisnal in the luminal membrane
It has been shown that HCCs appear hypointens in HP images – most likely due to the down-regulation of OATP1 and the increased expression of MRP2 –, even though they lack the characteristic enhancement features of HCCs in early dynamic phases, for instance, due to the persistent portal venous blood supply in early HCC , . Thus, Gd-EOB-DTPA might help differentiate small HCCs from dysplastic nodules and pseudovascular lesions, which do not commonly show hypointensity during the HP , . In our trial, however, 8 HCCs appeared isointens to hyperintens in relation to the surrounding liver parenchyma, most likely because of the high MRP2 expression in the canalicular membrane and the down-regulation of MRP2 in the luminal membrane .