Again, working upwards, since the 1960s and 1970s, we've tried, again, desperately to turn off molecules that operate between nerve cells -- serotonin, dopamine -- and tried to cure depression that way, and that's worked, but then that reached the limit.
再次重申，自下向上地， 从1960和1970年代开始， 我们当时还是竭力地 尝试去关闭神经细胞 之间运行的分子 如血清素、多巴胺 尝试从这个角度治疗抑郁。 一开始有一些进展， 但是很快就走到了尽头。