translation.en: We first began by looking at heart disease, and when I began doing this work 26 or 27 years ago, it was thought that once you have heart disease it can only get worse.
translation.zh: 我们最初从心脏病开始研究， 当我在26，27年前开始做这项工作的时候， 当时认为如果你得了心脏病，情况只能变得更遭。