Sofia is the daughter of Alejandra, who is Jorge's sister. This makes Sofia Jorge's niece. In relation to Luisa, since Luisa is Jorge's wife and not his sister, Sofia is her niece by marriage, not by blood. For Diego, since Sofia is the daughter of Diego's father's sister, Sofia is Diego's first cousin.

Alejandra does have a nephew, Diego, who is the son of her brother Jorge. Sofia and Miguel are her children, so they are not her nieces or nephews but her daughter and son.
Jorge has one sister, Alejandra. Alejandra is married to Carlos and they have two children named Sofia and Miguel. Jorge is married to Luisa and they have a son named Diego. How is Sofia related to Luisa and Diego, respectively? Does Alejandra have any nieces or nephews?

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