Jose is the husband of Catalina, who is Miguel's sister. Fernando is Miguel's son. This means Jose is Fernando's uncle by marriage. Ana is the daughter of Jose and Catalina, making her Miguel's niece. Since Isabel is married to Miguel, Ana would be Isabel's niece by marriage.
Miguel has a sister named Catalina. Catalina is married to Jose. They have two children, Ana and Carlos. Miguel is married to Isabel. Miguel and Isabel have a son named Fernando. How is Jose related to Fernando, and how is Ana related to Isabel? Make your response very short.