I don't think that there is a single contributor. I think everything on your list contributes, some more than others. Here are some examples from my perspective:
.
Increased medical costs and prescription costs create a barrier for some people seeking chronic pain relief. These individuals are in "survival mode" only looking to solve their immediate problem. These individuals will seek other means for relief which typically leads to heroin because its a lot cheaper and easier to get. This doesn't happen to everyone, but most heroin addicts started as chronic pain clients.
.
APD was literally gutted a couple years ago in an effort to reduce spending at the expense of public safety. I think we are seeing an increase in crime because of those cuts and an increase in catching them because of the current mayor's hiring spree. Unfortunately the DA's office just releases them via plea deals and bad policy which demonstrates to the thugs in training that there's no real consequences.