Fundamentally destroyed their lives?  
What regulations exactly interfere with your day-to-day living? 
And how dare he be responsible for more than 60,000 more Alaskans having access to health care that did not before?
It's true that it took awhile to turn the Great Recession around, global economic collapse is a b&tch, but we've had over 70 consecutive months of job growth.  And we are pretty much out of the two unfunded wars that W started, which caused the debt to explode, and the budget deficit is much smaller than when Obama took office.
Deficits cause debt.  
Republican presidents starting with Reagan almost without exception raise the deficit, Dems lower it.