When did Obama tell anyone to "sit down and shut up?"  Come on, give me a cite.   
Laws requiring auto insurance, regulations pertaining to food safety, airplane safety, drug safety, water safety, laws against murder, assault, driving while under the influence etc  interfere with someone's "day-to-day" living. What, exactly, are you talking about? Whose lives have been "fundamentally" or in any other way destroyed by "his" regulations?