The cultural conditions that developed in the south were inherently embedded for two hundred years prior to the outbreak of the war.  The war was about slavery, a system of bondage that was present in the north, even during the period of the Civil War.  Slavery was not unique to just the southern states.  Equally important - when the Constitution was drafted everyone at Constitution was afraid to tackle the ugliness of slavery.  The framers kicked the ball down the road at least twenty years thinking that somehow an answer would be forthcoming.  The second major problem with the Constitutional Convention and the men who ratified the Constitution in each of the thirteen states - each state had a different view of the powers of the federal government vis-a-vis state autonomy.  Hamilton, Adams, and Madison (to some degree) argued for a strong central government.  Jefferson, Patrick Henry and Anti-Federalists still believed the central government was subservient to state authority.