What is Pantothenate kinase-associated neurodegeneration?
'''Pantothenate kinase-associated neurodegeneration''' or '''Hallervorden Spatz disease''' is a rare [[disease]]. People with this disease have dementia, or extreme forgetfullness, and their face my twitch. Hallervorden-Spatz disease is degenerative [[brain]] disease, meaning the longer a person has it the worse the effects become. Scientists think it is caused by a build up of too much [[Iron]] in the brain. [[File:Pkan-basal-ganglia-MRI.JPG|thumb|Iron deposit in ''globus pallidus,'' imaging by [[Magnetic Resonance Imaging|MRI]]]] == Symptoms == The effects of the disease usually start at a young age and often result in a quick death. Some effects include: * Shaking of the arms and legs * Weakness * [[Muscle]] [[wikt:spasm|spasms]] ==Related pages== * [[ICD]] G 23.0 ==Other websites== * [http://www.medscape.com/viewarticle/447306 Defining Mutation Found in Hallervorden-Spatz Syndrome] * [http://cds.ismrm.org/ismrm-2004/Files/001423.pdf 1H MR Spectroscopy and Relaxometry for the Determination of Iron and Metabolite Concentrations in Hallerworden-Spatz Syndrome Patients] {{Webarchive|url=https://web.archive.org/web/20160304205726/http://cds.ismrm.org/ismrm-2004/Files/001423.pdf |date=2016-03-04 }} * Zumrova Alena ''et al.'' 2005. First cases in the Czech Republic of the Hallervorden-Spatz Disease resulting from mutation in the Pantothenate Kinase 2 Gene [http://www.nel.edu/pdf_/26_3/260305A04_15990724_Zumrova_.pdf Neuroendocrinology Letters No.3:26] [[Category:Diseases and disorders of the brain]]