What is Chaperone (protein)?
[[Image:GroES-GroEL top.png|250px|right|thumb|A top-view of a bacterial chaperone complex. This is a chapronin (HSP60) called GroEL.]] A '''molecular chaperone''' is a [[protein]] which does things to other proteins. They are mostly concerned with [[protein folding]].<ref>{{cite journal | vauthors = Richardson RT, Alekseev OM, Grossman G, Widgren EE, Thresher R, Wagner EJ, Sullivan KD, Marzluff WF, O'Rand MG | display-authors = 6 | title = Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation | journal = The Journal of Biological Chemistry | volume = 281 | issue = 30 | pages = 21526–34 | date = 2006 | pmid = 16728391 | doi = 10.1074/jbc.M603816200 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Alekseev OM, Richardson RT, Alekseev O, O'Rand MG | title = Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP | journal = Reproductive Biology and Endocrinology | volume = 7 | pages = 45 | date = 2009 | pmid = 19439102 | pmc = 2686705 | doi = 10.1186/1477-7827-7-45 | doi-access = free }}</ref> <ref>{{cite journal | vauthors = Ellis RJ | title = Molecular chaperones: assisting assembly in addition to folding | url = https://archive.org/details/sim_trends-in-biochemical-sciences_2006-07_31_7/page/395 | journal = Trends in Biochemical Sciences | volume = 31 | issue = 7 | pages = 395–401 | date = 2006 | pmid = 16716593 | doi = 10.1016/j.tibs.2006.05.001 }}</ref><ref>Hartl F.U. 1996. Molecular chaperones in cellular protein folding. ''Nature'' '''381''', 571–579 </ref><ref>Bartlett A.L. & Radford S.E. 2009. An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. ''Nat. Struct. Mol. Biol''. '''16''', 582–588 </ref><ref>Hartl F.U. & Hayer-Hartl M. 2009. Converging concepts of protein folding in vitro and in vivo. ''Nature Structural & Molecular Biology'' [[16]] (6): 574–581. [http://www.nature.com/nsmb/journal/v16/n6/full/nsmb.1591.html#B2]