What is Arthus reaction?
In [[immunology]], the '''Arthus reaction''' is a kind of local [[allergic reaction]], when [[antibodies]] react to a chemical or protein in a person's blood, and have the antibodies get stuck in the walls of [[blood vessels]] in organs such as the [[heart]], in [[joints]], and [[kidneys]]. ==History== The Arthus reaction was discovered by [[Nicolas Maurice Arthus]] in 1903.<ref>Injections répétées de serum du cheval chez le lapin, ''Comptes rendus des séances de la Société de biologie et de ses filiales'', Paris, '''55''' (1903), 817&ndash;820.</ref> Arthus repeatedly injected ingredients of [[horse]] [[blood]] under the skin of [[rabbit]]s. After four injections, he found that there was [[edema|swelling]] and that the mixture was absorbed slowly. Further injections eventually led to [[gangrene|dying of cells]]. Arthus reactions have been infrequently reported after [[diphtheria]] and [[tetanus]] toxoid [[vaccination]]s. They are rare and can cause pain, swelling, bleeding, and occasionally death of [[Tissue (biology)|tissue]] within 4–12 hours after the vaccine is given.<ref>[https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5503a1.htm Preventing Tetanus, Diphtheria, and Pertussis Among Adolescents: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccines], K. R. Broder et al., ''MMWR Recommendations and Reports'', March 24, 2006 / 55(RR03), 1&ndash;34, page 18.</ref> ==Related pages== * [[Serum sickness]] ==References== <references /> [[Category:Immunology]] {{biology-stub}}