What is Oxycodone?
{{Drugbox | verifiedrevid = 464196835 | drug_name = | IUPAC_name = (5''R'',9''R'',13''S'',14''S'')-4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one | image = Oxycodone.svg | width = 225px | image2 = Oxycodone structure.png | width2 = 225px <!--Clinical data--> | pronounce = ɒksɪˈkəʊdəʊn | tradename = OxyContin, others | Drugs.com = {{drugs.com|monograph|oxycodone}} | MedlinePlus = a682132 | pregnancy_AU = C | pregnancy_US = B | legal_AU = Schedule 8 | legal_CA = Schedule I | legal_DE = Anlage III | legal_UK = Class A | legal_US = Schedule II | legal_status = | dependency_liability = High | routes_of_administration = [[Oral administration|By mouth]], [[sublingual administration|sublingual]], [[intramuscular injection|intramuscular]], [[intravenous injection|intravenous]], [[intranasal administration|intranasal]], [[subcutaneous injection|subcutaneous]], [[transdermal administration|transdermal]], [[rectal administration|rectal]], [[epidural administration|epidural]] <!--Pharmacokinetic data--> | bioavailability = By mouth: 60–87%<ref name = MSR>{{cite web |title=Roxicodone, OxyContin (oxycodone) dosing, indications, interactions, adverse effects, and more |work=Medscape Reference |publisher=WebMD |accessdate=8 April 2014 |url=http://reference.medscape.com/drug/roxicodone-oxycontin-oxycodone-343321#showall}}</ref> | protein_bound = 45%<ref name = MSR/> | metabolism = [[Liver]]: mainly [[CYP3A]], and, to a much lesser extent, [[CYP2D6]] (~5%);<ref name = MSR/> 95% metabolized (i.e., 5% excreted unchanged) | metabolites = • [[Noroxycodone]] (25%) <ref name=Medscape>{{cite web |title=Roxicodone, OxyContin (oxycodone) dosing, indications, interactions, adverse effects, and more |work=Medscape Reference |publisher=WebMD |accessdate=4 January 2019 |url=http://reference.medscape.com/drug/roxicodone-oxycontin-oxycodone-343321#showall}}</ref><br />• [[Noroxymorphone]] (15%, free and [[Conjugation (biochemistry)|conjugated]])<ref name=Medscape /><br />• [[Oxymorphone]] (11%, conjugated)<ref name=Medscape /><br />•