TLDR: if you love an interesting visual treat and a sci-fi/time-travel based adventure story, you'll most likely enjoy this. I enjoyed it very much, and I think those were the defining factors for me. (I have also seen most of the MCU, but the marvel references weren't a defining factor for me.)

Firstly, I think the biggest win for this show is the visual and production design. From the retro design of the TVA to the sci-fi planets, it's a delight to watch. The VFX, a bit over the top as always with marvel, is seemingly better than some of their blockbuster films. Most of the VFX feels more believable. Seriously, the design of TVA, and especially the graphics of their devices are awesome. It makes me want to sit down and code websites in that style!

Secondly, the story is fairly good. It's especially good for a marvel story, bringing a bit of complexity and character development which is often lacking. I wouldn't say it's the best story ever, but definitely much better than plenty of the marvel movies and the other shows. To me, this was a fantastic story for an action/adventure genre, a genre which is typically lacking in the story department (at least, comparing blockbuster, PG-13-type action flicks). The dialogue is reasonable too. Specifically, I wasn't distracted by bad dialogue, and I often am in other action movies and shows. The story develops Loki pretty significantly as a person.

Finally, the concept of the TVA in general is very intriguing. It has some weak points (specifically, I'd love if there was more explaining about how the system and science works), but is overall an interesting plot to explore. However, it does feel unrelated from the marvel universe. It will require some work to tie it in, if at all. When dealing with time, and specifically determinism, it's very easy to start thinking that nothing matters. But what if everything IRL already is deterministic? This is simply a part of life that we might have to interact with and come to our own conclusions on. So it's not bad for us to have our thoughts provoked by media on the subject!

That said, this requires a bit of suspension of disbelief. As an example from other shows, Captain Marvel is shown to have powers pretty far beyond the supes we know and love. But that doesn't stop us from enjoying Captain America. Similarly, the time aspect of this show does not have to stop us from enjoying things like Endgame. That said, they should have just removed the few lines quipping about infinity stones. To me, it was an unnecessary point to make, as it made no impact on the story. (Or at least, the small impact of the revelation was easily mitigable.) It would be nice to get a very well developed integration and explanation... But this is marvel, after all. For now, you'll enjoy the show much better if you think of it as mostly standing on its own two feet! I certainly enjoyed it very much, which is why I rated it highly.