Pretty much the biggest hit on the score is when they forget a lot of the main characters right within the first few episodes and do not even revisit until many episodes later.

That and Senku's catchphrases can be annoying you can play a drinking game with the amount of times he says "Get Excited" and "10 billion" or "1mm" of something. That coupled with his personality and no real love interests make him one of my most hated anime protagonists.

The show is original and interesting so I will continue to watch if anything to see what happened to the world.