Peter Bretter (Jason Segel) is a TV musician for the show Crime Scenes. His girlfriend Sarah Marshall (Kristen Bell) is the star of the show. Then his life falls apart after she breaks up with him. He escapes to Hawaii for vacation but runs into Sarah and her new boyfriend rocker Aldous Snow (Russell Brand). The concierge Rachel Jansen (Mila Kunis) takes pity on him and gives him a great beach side cottage.

This is pack full of hilarious people who are doing great work. It starts with a gut busting hilarious crying penis breakup scene. The best side character is Jack McBrayer's sexually repressive newlywed. This is not just a run-of-the-mill rom-com. It is inventive, hilarious, and touching.