B Hs1912, Churchman noted the bacteriostatic action of GV against Gram-positive microorganisms both in vitro and in animal studies.8 Based upon results from Churchman, in 1925 Hinton used GV intravenously in 12 patients with severe sepsis from Gram positive organisms, of which seven patients improved.9 In 1928, a case of staphylococcal meningitis was also cured by intrathecal injections of GV.10 Throughout the first half of the 20th century, GV was widely adopted for use in a variety of diseases including trench mouth11, thrush12, impetigo13, burns14, pinworm15, cutaneous16 and systemic fungal infections17. Claims of GVs efficacy during this time.