text: Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease
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  BACKGROUND: The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilizing flow cytometry to identify circulating, collagen type 1+ cells, we found two populations: (i) CD45+ CD34+ (fibrocytes) and (ii) CD45+ CD34- [myeloid-derived suppressor cell (MDSC)-like fibrocytes] cells in stable COPD (n = 41) and control (n = 29) subjects. Lung resection material from a separate group of subjects with (n = 11) or without (n = 11) COPD was collected for tissue fibrocyte detection. We examined circulating fibrocyte populations for correlations with clinical parameters including quantitative computed tomography (qCT) and determined pathways of association between correlated variables using a path analysis model. RESULTS: Blood and tissue fibrocytes were not increased compared to control subjects nor were blood fibrocytes associated with lung function or qCT, but were increased in eosinophilic COPD. Myeloid-derived suppressor cell-like fibrocytes were increased in COPD compared to controls [2.3 (1.1-4.9), P = 0.038]. Our path analysis model showed that collagen type 1 intensity for MDSC-like fibrocytes was positively associated with lung function through associations with air trapping, predominately in the upper lobes. CONCLUSION: We have demonstrated that two circulating populations of fibrocyte exist in COPD, with distinct clinical associations, but are not prevalent in proximal or small airway tissue. Blood MDSC-like fibrocytes, however, are increased and associated with preserved lung function through a small airway-dependent mechanism in COPD. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
  AuthorsWright, AKA; Newby, C; Hartley, RA; Mistry, V; Gupta, S; Berair, R; Roach, KM; Saunders, R; Thornton, T; Shelley, M; Edwards, K; Barker, B; Brightling, CE
  - Population Health
explanation: The provided text is a scientific abstract from a research study that investigates the role of fibrocytes and myeloid-derived suppressor cell-like fibrocytes in chronic obstructive pulmonary disease (COPD). The study uses flow cytometry to identify and enumerate these cell populations in blood and tissue samples from COPD patients and control subjects. The results show that while blood and tissue fibrocytes are not increased in COPD, myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function. The text does not contain any math questions or answers.
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distilabel_metadata.role: system
distilabel_metadata.content: Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease
  MetadataShow full item record
  BACKGROUND: The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilizing flow cytometry to identify circulating, collagen type 1+ cells, we found two populations: (i) CD45+ CD34+ (fibrocytes) and (ii) CD45+ CD34- [myeloid-derived suppressor cell (MDSC)-like fibrocytes] cells in stable COPD (n = 41) and control (n = 29) subjects. Lung resection material from a separate group of subjects with (n = 11) or without (n = 11) COPD was collected for tissue fibrocyte detection. We examined circulating fibrocyte populations for correlations with clinical parameters including quantitative computed tomography (qCT) and determined pathways of association between correlated variables using a path analysis model. RESULTS: Blood and tissue fibrocytes were not increased compared to control subjects nor were blood fibrocytes associated with lung function or qCT, but were increased in eosinophilic COPD. Myeloid-derived suppressor cell-like fibrocytes were increased in COPD compared to controls [2.3 (1.1-4.9), P = 0.038]. Our path analysis model showed that collagen type 1 intensity for MDSC-like fibrocytes was positively associated with lung function through associations with air trapping, predominately in the upper lobes. CONCLUSION: We have demonstrated that two circulating populations of fibrocyte exist in COPD, with distinct clinical associations, but are not prevalent in proximal or small airway tissue. Blood MDSC-like fibrocytes, however, are increased and associated with preserved lung function through a small airway-dependent mechanism in COPD. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
  AuthorsWright, AKA; Newby, C; Hartley, RA; Mistry, V; Gupta, S; Berair, R; Roach, KM; Saunders, R; Thornton, T; Shelley, M; Edwards, K; Barker, B; Brightling, CE
  - Population Health
distilabel_metadata.role: user
distilabel_metadata.raw_output_q_a_detector_0: The provided text is a scientific abstract from a research study that investigates the role of fibrocytes and myeloid-derived suppressor cell-like fibrocytes in chronic obstructive pulmonary disease (COPD). The study uses flow cytometry to identify and enumerate these cell populations in blood and tissue samples from COPD patients and control subjects. The results show that while blood and tissue fibrocytes are not increased in COPD, myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function. The text does not contain any math questions or answers.
  
  Label: no-question