The setting up of cooperation for innovation is a major challenge for small businesses. Within the open innovation field, this article addresses the influence of SMEs’ location and digital resources on their innovation cooperation profile. This cooperation profile combines the type of partners, their diversity, but also the geographical scale of the partnerships. We use a double data source. A quantitative survey is used to link the cooperation profiles to the location and digital resources of a sample of 269 SMEs; a qualitative survey of 7 SMEs representative of the identified profiles illustrates and complements the results highlighted by the quantitative analysis. We show that SMEs’ innovation cooperation profiles are more strongly influenced by their digital practices than by their location.