On October 17, 2018, Canada became the first Western country to legalize cannabis for recreational use. The policymaking process was characterized by a top-down and often unilateral decision-making approach on the part of the federal government. Nevertheless, the provinces had important prerogatives, which they used to adapt or even resist the framework proposed by the federal government. Using the concept of resistance strategies, this article analyzes how some provinces, especially Quebec, took advantage of the policymaking process to provide a counterweight to the federal government’s coercive approach. Quebec used both offensive and defensive strategies to resist federal policy from the formulation to the implementation stage. The article emphasizes the importance of studying cannabis policy implementation in Canada, which has led to a variety of policies rather than to a uniform framework.