Throughout history, academic researchers have participated in the destruction and devaluation of First Peoples’ intellectual, spiritual and cultural resources, contributing to the erasure of these communities’ ways of thinking and being (Ferrazzi, Tagalik, Christie et al., 2019). In response to this reality, for nearly 10 years, Pitutsimajut Partnership-Research – our research team – has been developing collaborative projects with partners in Nunavik to support the self-determination process of communities and organizations in the region by co-developing tools and services that are guided by Inuit knowledge, are culturally grounded, and safe for northern children, families, and communities. The literature on participatory research offers us insights into the principles and ethical reflections that can guide our actions. Through our partnerships, we felt the need to share our experience, contributing to the knowledge about the specificities of participatory action research practices. In this article, we look at the involvement of stakeholders, preferred processes, essential principles as well as challenges encountered over the years. This article sheds more light on the articulation of participatory action research in an Indigenous context.