The article considers three basic concepts as required by the study of human settlements morphogenesis. At first, is analyzed the organizational center of some cities and towns, that is to say the origins of those settlements, their attracting power, the meaning invested in their places and their lasting through centuries. Next, are pointed out the spatial interaction schemes, which are conceived so as to make possible passing from the microgeographic level of the subjects and the functions, to the meso-geographic level on which is displayed the morphologic structuration of the intrinsic organization of agglomerate settlements. At last, a dynamic model of anisotropic space is made explicit. With the help of this model we can recognize the way in which morphogenetic gradients segment the subjacent abstract spaces of the agglomerate settlements into qualitatively differenciated domains. Some examples from the morphogenesis of Paris are added.