In 2013, there will be 1.2 billion teleworkers around the world. How can a manager motivate and mobilize such employees, create a feeling of belonging to their company, and ensure that each individual feels important and wants to get involved? This article presents the results of a study that sought to identify effective management practices and understand the determinants of effectiveness. Our analyses enabled us to identify five practices and to propose a model that explains effective leadership in the context of management of teleworkers.