Solving the problems related to the people with disabilities represents one of the major challenges of the western countries. Nowadays, the handicap is not dealt as an individual problem but concerns the whole society and its environment. Contrary to the richer countries, in the developing countries, like the Republic of Guinea, the majority of the people with disabilities are extremely poor and neglected. In this context, they adopt various strategies in order to fulfill their needs. In our work that was carried out in Conakry during 2008, we studied a group of individuals with disabilities, induced by the infirmity of the lower members. Subsequently, we established three profiles corresponding to three different subsistence strategies. Then we analyzed how different factors influence the persons to prefer one strategy over the other, as well as the consequences of their choice on their social participation and integration.