Antidepressants are one of the most prescribed and consumed drugs in Quebec, Canada and other Western States, not only for depressions but also for various and diverse afflictions. They have become a highly rated “merchandise” for which the use value, in other words its social utility, is the promise of restoring the depressed individual’s action. In this article, we will consider, from the perspective of users, the complex experiences that come with taking antidepressants in order to seize the typical tensions that most describes them, the general characteristics that best distinguishes them and the collective dimensions that link them together while conferring them a certain unity.