This contribution describes a transdisciplinary research project studying the social participation of young people with sickle cell disease and eventually neuropsychological disorders, living in Guadeloupe. The theoretical and methodological framework leading this research is the second version of the Disability Creation Process (Fougeyrollas, 2010; Fougeyrollas, Boucher & Charrier, 2016) and its measuring tools (LIFE-H4.0, Fougeyrollas, Noreau & Lepage, 2014, and MQE 2.0, Fougeyrollas, Noreau, St-Michel, & Boschen, 1999). Firstly, the theoretical and practical choices will be warranted: the cultural adaptation of the tools, regarding the specific local context, and regarding the chronic disease of our main study population (N=102, between 6-16 years). A control group (N=45) allows us to investigate a possible effect of the cultural context on participation and on the perception of the environment, as no study has been conducted yet in such a context. The life trajectory or « career » of the young chronically ill and their close family can be highlighted by biographic narratives interviews. This timeframe is relevant in relation to the DCP-2, as it provides a diachronic perspective in addition to the initial synchronic description of the model. To conclude, we will focus attention on the epistemological issues implied by the crossdisciplinarity of such a research, a particularly topical issue in the field of health research (Trabal, Collinet & Terral, 2017;Trabal, 2019).