In Quebec, knowledge about adapting health and social services with the health-related needs of sexual minorities remains scarce. A participatory action-research at Centre de santé et de services sociaux (CSSS) Jeanne-Mance in Montreal has the objective of measuring the adequacy of their services with the needs of lesbian, gay, bisexual, transgender or transsexual (LGBT) individuals. Interviewing key informants, the first phase of the research had the objective of documenting challenges related to adapting services. Apart from practices already developed at CSSS to meet their needs, we find among other elements to be considered the question of welcoming, the process of identifying needs, communication techniques to develop trust as well as the specific needs for each subgroup among sexual minorities. The article also raises the necessity of considering the improvement of staff training and the risks or benefits of specific services for these populations.