This article aims to explore, within the framework of Freudian critique, transdisciplinary and innovative concepts of perverse necrophilic humor and comedy. In order to disturb the readers’ moral, aesthetic and sexual points of reference, the strangest novels of the Marquis de Sade (The One Hundred and Twenty Days of Sodom, Juliette or Justine) sometimes offer, according to the perverse scenarios, humorous treatments and/or comical practices or necrophilic fantasies.