In analyzing discourses about the death by overdose of the playmate Anna Nicole Smith, I try to think how antidepressants and our collective imaginary of “beautiful women” suicides are important ingredients in the social consitution of female sex appeal. We see a pathologization of the female body (Foucault) that has become the target of pharmaceutical companies offering not only health but beauty. A cursory glance at the links between photographic history and mental health (Charcot ; see Didi-Huberman) allows us to see how the images in publicity now continues the work of representation begun by the 19th century invention of the depressive face. But the contemporary face signaling feminine disturbance represents more than ugliness. That is to say that the images of the feminine breakdown are mingled with the images of desire. The antidepressant becomes the product that domesticates the female disorder while, at the same time, rendering this disorder seductive and harmless for society.