Although conduct disorder is among disorders mostly associated with substance misuse at the adolescence, relatively few studies examined the characteristics of this consumption of teenagers who have a diagnosis of conduct disorder. Based on many indicators of the severity of the substance consumption, the purposes of this study were to describe substance consumption pattern of boys and girls with conduct disorder (N = 181) and to determine if their consumption is different from that of teenagers who also have antisocial behaviour, but no diagnosis of conduct disorder (N = 204). The results showed that youths with conduct disorder are significantly different from youths without conduct disorder on almost all indicators of severity. The use of hard drugs, regular consumption and presence of negative consequences associated with substance use were the indicators mostly related to the presence of a conduct disorder. These findings are examined in the perspective of treatment programs for youths with conduct disorder.