To succeed in meeting the many challenges posed by climate change, humanity needs to broaden the scope of possibilities and undertake a profound social and political transformation with a view to achieving greater social and environmental justice. For the sociologist and epistemologist Boaventura de Sousa Santos (2016), global justice cannot be achieved without the pursuit of global cognitive justice. And the latter must recognize the incompleteness of modern Western rationality. Education on climate change, to be truly transformative and bearer of eco-social justice, must, in the same way, be open to alternative subjectivities and experiments. This article reviews the work Epistemologies of the South written by Boaventura De Sousa Santos (2016) by attempting to highlight the main concepts developed by the author and which seem promising for thinking about an Education on climate change with a transformative scope and focused on eco-social justice.