Among the municipalities of Québec most often hit by floods, those located in the Beauce and Estrie regions, which are regularly affected by this phenomenon, deserve attention. In Estrie, towns such as Sherbrooke, Bromptonville, Richmond and Windsor regularly suffer the consequences and damage associated with flood events. Despite the efforts of local authorities and managers in the past, the problem remains whole and always current for these riverside municipalities. The present study establishes the historical chronology of flood events (high flows and major floods) which had a significant impact on the towns in the Estrie region during the period 1900-2000. A presentation of the flood data is followed by a brief analysis of hydroclimatic conditions associated with flood events and of the major anthropic modifications that have occurred in this area.