The death of a child during pregnancy or in the days after birth is an event that affects nurses. When they are faced with the intense emotions of parents, nurses in perinatal settings must continue to provide care, while managing their own emotions. This article aims to review what is known about the psychosocial factors of the work environment when a perinatal loss occurs in perinatal setting and their effects on the health of nurses. In order to provide a strategy that can contribute to the mitigation of these stressors. Karasek and Theorell’s (1990) Demands Control Support model guided the entire reflection with its concepts : job demands, control and social support. Findings revealed that it would be beneficial to improve the support from the Organizations and better prepare nurses so they can face the challenges of perinatal death.