This study evaluates the short-term behavioral outcomes of a cognitive- behavioral program delivered to adolescent females in a youth residential center. Other objectives include : to verify whether the effects varies according to the females’ degree of participation in the program ; and to determine the effect sizes of the program. The evaluation design is quasi-experimental. The experimental and control group are composed respectively of 107 and 77 adolescent females. All participants have been assigned to a youth center for a continuous duration of at least three months. The results support the use of behavioral-cognitive interventions with adolescent females presenting problem behaviors. Half of the observed effects are clinically significant, especially when the degree of participation in the program is higher. Two other effects indicate that behavior modification is in progress. This study represents a first step in the evaluation of the effectiveness of cognitive-behavioral programs for adolescent females presenting problem behavior.