Wine has been linked to Spanish culture since the time of the Romans and early Christianity. In Spain, a land of vines since antiquity, the representation of the drunken body in literature and painting is an omnipresent topos since the Middle Ages. The pros and cons of this are found in medical, philosophical, moral and religious texts, but especially in novels, which warn against excess. This article studies how Spanish painters and writers developed the imaginary of wine in all its forms, be they masculine or feminine, solar or twilight, enthusiastic or drowsy, in their reflections, in their drawings and paintings, in poems or novels, in order to transmit the ideological transformation that was going to occur in Spain around this drink. For only the artist seems to preserve the tradition of the divine origin of wine, reclaiming its thaumaturgical role thanks to the Bacchic nectar. Spanish men and women suffer or benefit from the virtues of wine, the main alcoholic beverage in Spain until the 21st century.