Before the 2010 national survey on gambling, France had not taken on the task of quantifying the prevalence of gambling and problem gambling in the general population. Objective: This study presents, by way of analysis of the 2010 Baromètre-Santé survey dataset, a description of gambling habits and patterns in France. It examines the demographic profile of current players, the gambling practices of involved gamblers, that is, players who show a high engagement in gambling either in terms of frequency of participation in gambling activities or in the amounts of spending, as well as the associations between problem gambling and substance use. Methods: Participants reported on the frequency of participation to various gambling activities and spending, the assessment problem gambling severity (CPGI), and measures of consumption of psychoactive substances. Participants: The general survey was conducted in May 2010 using a representative sample of 25,034 individuals aged between 15 and 75 years. Results: The results show that nearly 12% of the general population were considered as involved gamblers, who have gambled 52 times or more or have spent 500 euros or more during the last 12 months. The proportion of involved gamblers was higher among men, individuals between 35 and 44 years of age and those who are active on the labor market. The proportion of problem gamblers among involved gamblers is estimated at 3.7% and moderate-risk gamblers at 7.1%. Problem gamblers are more often men from low socioeconomic backgrounds. The survey also found a significant relationship between the most risky gambling practices and problematic consumption of alcohol, tobacco and cannabis. Conclusion: The inclusion of a greater set of questions on gambling and other health practices will better our understanding of risk factors and vulnerabilities to problem gambling.