Some families face great vulnerability due to various factors such as personal and familiar history, poverty, social isolation, etc. In such situations, the ability of parents to take care of their children can be rather limited. In Italy, in order to support vulnerable families and more particularly neglectful ones, child -and-family educational home interventions are widespread. However, to date there has been little far-reaching evaluation of their effectiveness. This article reports the results of a joint research-training-intervention project that involved 12 educators and 18 deemed negligent families over an intervention period of 12 months. The evaluation permitted identification of the key factors fostering the adaptation of these families.