The exercise of universal jurisdiction highlights a potential contradiction between fundamental principles of international law, i.e., on the one side, State sovereignty and non-interference in States’ internal affairs and, on the other, the fight against impunity for international crimes. Whereas the African Union has frequently affirmed its support for a robust system to fight impunity, it has opposed what it perceives as an abusive exercise of universal jurisdiction by certain States, mostly European. This article addresses, in light of the African Union’s main legal positions, a few potential limits that allow for a sensible notion of universal jurisdiction.