Multiple sclerosis (MS) is a progressive and episodic disease. These characteristics of the disease progression make it different from other incapacitating conditions. To collect data on their social participation and to determine what personal factors influence it, 89 people answered questionnaires. Results expose some features of the disease that could influence social participation, such as diagnosis’ duration, symptomatology and socioeconomic profile of those affected. ANOVA analysis show what factors influence social participation quality in two specific social roles: recreation and interpersonal relationships. Conclusion focus on the importance of social worker to accompany people with MS in facing all the changes in social role realization coming from the disease.