This study was conducted to evaluate the health risk associated to yard waste generation in rural area of Irhambi Katana in Eastern Democratic Republic of Congo. Quantities of wastes produced per household in six Irhambi Katana villages as well as microbiological analysis of wastes samples were performed. Health centers data were analyzed and wastes contribution in soil nutrients was determined. The households of Irhambi Katana Sub County produce an average of 0.3 Kg of wastes per day. These domestic solid wastes embody many pathogenic agents such as Balantidium coli, Shigella flexneri, Ascaris lombricoïdes and Escherichia coli which can be associated to diarrhea diseases currently encountered in the statistics of health centers such as ascardiose, shigelose, amibiase and cholera. In addition these solid waste have high organic nutrients content such as nitrogen and phosphorus (1272 mg P/kg; 8.89 % N) in the wastes. A sensitization of the population on domestic solid wastes management to avoid diseases due to poor waste management and the use of domestic waste for compost are recommended.