Focused on « Actor-Network Theory » concepts (Callon, 1986; Latur, 2005), this paper offers an innovative perspective of participatory research in CSSS-CAU. The case of partnership ARIMA, created in Quebec by the Centre de recherche et de partage des savoirs InterActions, helps to illustrate how participatory research practices are gradually organized as innovative networks of knowledge translation. The partnership configuration of this network is associated to many potentially transforming translations. This gives participatory research a perspective of innovative practice which is performed in a complex context of intersectoral knowledge mobilization.