Coping with multiple sclerosis (MS) is a challenge that must be faced every day. Conceptualizing the coping process for people with multiple sclerosis (MS) based on bereavement theories provides for reflection that leads to possible interventions. The specific characteristics of coping with MS are described so as to establish a connection between the principal steps in the process, its derivatives and its impasses, which are defined as coping problems. According to recent literature, meaning is a decisive factor in the case of successful coping and resilience. Studies tend to demonstrate that people with MS experience fewer coping problems when they manage to give meaning to their disease. As a result, facilitating coping through a search for meaning is pertinent. A group activity is presented to illustrate such a rehabilitation intervention.