Humanitarian caregivers work in unstable contexts that challenge their subjectivity. They are confronted with extreme working conditions and develop relationships with their patients which are quantitatively intense and imprinted with unsymbolized contents. In response to this experience of high traumatic potential, they erect various defensive systems (expulsion of quantity, “cutting” away from themselves, etc.) and present a variety of symptoms more or less expensive for the psyche. In connection to their response to the extreme situation, they also express a demand or a need for the support of their ego to which the object-environment responds in a more or less adjusted way. Thus, this article proposes a psychoanalytical look at the clinic of the extreme, and suggests metacontaining modalities that could act as protective factors for caregivers.