Nursing programs are highly competitive and stressful environments; nursing educators are looking for ways to mitigate the negative consequences of demanding training programs. This article explores and compares the mental health status and sociodemographic and personal characteristics that influence the psychological distress of nursing and non-nursing students learning in either official language of Canada. An online and paper survey was administered during class time to 990 students, 186 of whom were in an undergraduate nursing program in one of two postsecondary institutions in Manitoba, Canada. Findings demonstrate that students in nursing programs are more likely to report poor mental health than students in other undergraduate programs and that nursing students in the French-language institution report poorer mental health outcomes as compared to nursing students in the English-language institution. Life satisfaction and high self-esteem are positively associated with well-being, whereas age, gender, and learning in a second language are risk factors contributing to anxiety.