This article presents the results of an exploratory research conducted with young people attending Auberges du coeur that host troubled and homeless youth in Drummondville and Montreal. We looked at their relationship to mental health diagnoses and medication, and how they are followed by health professionals. We will revisit three key elements of our study: 1. the existence of long processes of solitary adjustment with regard to medication that may result in the abandonment or refusal of prescription; 2. the difficulties of accessibility to certain services, including psychological help; 3. the development of an ambiguous relationship, both “expert” and “critical” with the uses of the medication, leading to a distancing from certain institutions, medical or related to social services.