Inside an international institution such as the World Trade Organization (WTO) where strong asymmetrical relations prevail, the weakest countries are generally disadvantaged. However, they can reverse the trend by developing coalitions as suggested by the theoretical literature. This is the route chosen by many developing countries in the WTO. Over time, their coalitions have become much more effective in countering the claims of the most powerful countries which want to strengthen patent law. Coalition of developing countries that mobilized around issues of intellectual property and biopiracy countries has shown some success, which can be explained by the choice of a form combining strength and flexibility.