From the first uses of databases in the 1970s to recent research on the analysis of audio files, musicologists have progressively integrated digital technologies into their working methods. However, while some software such as iAnalyse offers interfaces adapted to the human sciences, it has been observed that these technologies are still difficult to manipulate without a solid knowledge of computer science or acoustics. In this article, the author presents an interdisciplinary practice of research at the heart of digital musicology that covers a very wide field of activities ranging from the use of software to improve existing methods to the development of new methods that are necessary to study specific corpus. In this case, the deep transformation of the nature of musicological practice itself, the move towards a hybrid discipline and the change of perspective on a complex musical object highlight a real epistemological rupture.