The extension of university work at the local level is the expression of the actions in the field of knowledge management carried out in a territory, with the political will of associations and organizations. This article presents the experience in the application of some demographic and epidemiological indicators during the COVID-19 pandemic in the geographical areas of the Popular Councils of the municipality of Santa Cruz del Norte, Mayabeque, during the year 2021. These two sciences share certain topics of interest, as well as some characteristics of the perspectives from which they are approached. The topics related to the characterization of the Sociodemographic situation of the municipality, the epidemiological context of the pandemic are presented at the local level, focusing on population and the results of the application of a technical guide for risk assessment stratified in these geographical areas. Conclusions are issued for possible application in other territories.