This article presents research results on the identification of health indicators, which can influence the intensity of mourning reactions in parents who experience the death of their baby during the perinatal period. This type of loss provokes major existential questions, which seem to impact the health of grieving parents. The purpose of this descriptive study was to verify the role that the meaning of life has on the perception of loss and the reactions of the parents two and six months after the loss of their baby. The results highlight the importance of supporting families who demonstrate a less positive meaning of life, a stronger negative perception of the loss and a weak social support network. Greater exploration of the father’s reactions to the death of the baby is recommended as well as the necessity to grant him equal importance with the mother in the offered follow-ups. For the clinical milieu, we suggest the exploration of health indicators to better adapt the follow-ups to the family’s needs.