Based on the Ligue des droits et libertés’s (LDL) past and recent experiences, this article highlights key issues related to the enactment of the term « systemic racism » in the context of struggles to promote human rights in Quebec. After a brief overview of the struggles against racism and discrimination led by the LDL since its creation, I explore the recent discursive and analytical shift of this organization towards the systemic approach to racism. I demonstrate the value of this perspective in the promotion of human rights practices, mainly in terms of education, awareness-raising campaigns, networking and mobilization, as well as sociopolitical analysis. I conclude by showing the strong links between the concept of systemic racism and the interdependence and indivisibility of human rights, two principles which are at the core of international law and LDL’s human rights practice.