Preparing students to deal with and tolerate uncertainty or ambiguity is a major issue in medical education. There are many English scales to assess tolerance of uncertainty and ambiguity but no French one has ever demonstrated validity evidence for its scores. We selected the Tolerance of Ambiguity in Medical Students And Doctors scale. In a structured process, the original questionnaire was translated, culturally adapted and assessed after administering it to a sample of medical students. Test-retest reliability was tested by presenting the questionnaire to the students again after two months. The assessment of internal consistency reveals satisfactory value. Test-retest reliability is assessed by intraclass correlation that presents good reproducibility of scores obtained by students in first completion and second completion. These results indicate that the French version of the TAMSAD scale can be used to assess French medical students’ tolerance to ambiguity.