What's the best way to defeat depression?
There is no single "best" way, but there are several things that can help:

1. Exercise - Regular exercise has been shown to be an effective treatment for many mental and physical conditions. It can boost mood, increase energy levels, improve sleep quality, reduce stress hormones, build muscle strength, and decrease risk of injury. 
    - If you're not used to exercising regularly it may take some time before you see results. Keep at it! 
2. Dietary changes - There is evidence that a healthy diet low in sugar and refined carbohydrates (especially those high in carbs), rich in fruits, vegetables, lean proteins and healthy fats can contribute towards reducing symptoms of depression.  It doesn't matter if you follow this type of diet religiously or just try to make small changes; it works. Try incorporating more fish into your meals, which contains Omega 3 fatty acids, one of the key ingredients found to help combat depression. Also consider increasing consumption of dark chocolate as studies show that compounds within the cocoa bean have antidepressant effects. Additionally, cutting down on caffeine intake and eating foods rich in B vitamins like eggs, poultry, dairy products, whole grains can also aid in managing symptoms of depression. 

3. Therapy/medication - Talk therapy such as cognitive behavioral therapy (CBT) or interpersonal psychotherapy (IPT) have been proven to be helpful for people with mild to moderate depression. However, talk therapies alone cannot replace medication when necessary. 

4. Supplements - A few supplements may offer additional benefits including magnesium, SAMe (S-adenosylmethionine), omega-3s, 5-HTP (5-hydroxytryptophan), Ginkgo biloba, phosphatidylserine, vitamin D, L-tryptophan, St John’s Wort, melatonin, ginseng, andSAM-e. Research shows these supplements might help prevent depression from developing by enhancing neurotransmitter function and improving overall brain health